Circulation
Articles in this Issue
Abstract 4362048: Relationship between menopause timing and age-associated pulse pressure widening in the Framingham Heart Study
Background and Research Question: Increasing pulse pressure (PP) occurs with aging and is a risk factor for CVD. PP is shown to fall to a nadir in midlife with subsequent increase...
Abstract 4366332: MAP2K6 as a Modulator of Cardiomyocyte Stress and Metabolic Dysfunction in HFpEF
Introduction: The failing myocardium displays disrupted intracellular signaling, leading to pathological remodeling. Heart failure includes two major subtypes: HFrEF and HFpEF, cha...
Abstract 4364619: Performance of the ACTION Screening Criteria in Identifying Fontan Patients at Risk for Adverse Outcomes: A Single-Center Case-Control Study
Background: While Fontan palliation offers improved long-term survival for patients with single ventricle congenital heart disease, many eventually develop Fontan circulatory failu...
Abstract 4371043: Sex-Based Differences in Post-Heart Transplant Outcomes: A systematic review and Meta-Analysis
Background: Sex-based disparities in heart failure and transplant outcomes are increasingly recognized. Although women represent a minority of heart transplant recipients, conflict...
Abstract 4366681: Incidence and Predictors of Atrial Fibrillation after Heart Transplantation
Background: Atrial fibrillation (AF) has been associated with increased morbidity and mortality in patients after heart transplantation (HT); however, little is known about the inc...
Abstract 4344658: Endothelial cell specific senescent cell clearance alleviates metabolic dysfunction in obese mice
Aging is the leading risk factor of chronic diseases including cardiovascular diseases and metabolic diseases. Emerging evidence suggests cellular senescence, one of the pillars of aging, plays a caus...
Abstract 4354896: Intracranial Hemorrhage in Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock
Background: The incidence and predictors of intracranial hemorrhage (ICH) in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (AMI-CS) remain unclea...
Abstract 4371788: Evaluating Remote Versus Clinic-Based Follow-Up in Postpartum Hypertension: A Systematic Review and Meta-Analysis
Introduction: Hypertensive disorders of pregnancy (HDP) contribute to postpartum complications and readmissions. Remote blood pressure monitoring (RBPM) offers an effective alterna...
Abstract 4369728: Electrocardiographic Aging in Genetic Cardiomyopathies: Insights from an Artificial Intelligence-Enabled Electrocardiogram Analysis
Background: Arrhythmogenic and dilated cardiomyopathies (ACM/DCM) are associated with adverse cardiovascular outcomes, including sudden death. Artificial intelligence (AI)-enabled...
Abstract 4366960: Interhospital Transfer versus Direct Admission for Percutaneous Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Systematic Review and Meta-analysis
Background: Timely reperfusion with primary percutaneous coronary intervention (PCI) is critical for patients with ST-segment elevation myocardial infarction (STEMI). However, whet...
Abstract 4366734: Mortality Prediction in Cardiogenic Shock Using a Time Series Machine Learning Foundation Model
Introduction: Traditional risk models predicting mortality in cardiogenic shock (CS) rely on static data snapshots, failing to capture the temporal dynamics represented in electron...
Abstract 4365373: An Innovative Human iPSC Cardiomyocyte Platform to Accelerate Cardiac Drug Discovery and Target Validation
Background: Effective treatment of cardiac diseases requires a deep understanding of disease-relevant cellular mechanisms that drive pathology in the human heart. Traditional cell...
Abstract 4365129: Young Microbiome Transplantation Enhances Recovery after Myocardial Infarction
Background: The relationship between aging, gut microbiota, and cardiac repair after myocardial infarction (MI) remains unclear. Understanding this interaction may provide novel st...
Abstract 4370192: Nocturnal Very Low Frequency of Heart Rate Variability Predicts Adverse Cardiovascular Events in Obese Individuals
Background: The risk of major adverse cardiovascular and cerebrovascular events (MACCEs) in obese individuals is often assessed by hypoxia and hypopnea levels, while heart rate var...
Abstract 4362928: Very High HDL Cholesterol Is Associated With Increased Risk of Heart Failure Hospitalization
Background: Emerging evidence suggests that very-high High-density lipoprotein cholesterol (HDL-C) levels are paradoxically associated with adverse clinical outcomes. We investigat...
Abstract 4369942: Improvements in right ventricular function with percutaneous tricuspid valve replacement as assessed by the right ventricular index of myocardial performance
Right ventricular dysfunction (RVD) with severe tricuspid regurgitation is a major prognostic factor in cardiopulmonary disease, yet the effects of improving tricuspid regurgitation remains unknown. I...
Abstract 4364295: Heart Rate Variability Metrics from Wearable Devices Predict Symptom Flares in Female Chronic Pelvic Pain Disorders
Background: Female chronic pelvic pain disorders (CPPD) are marked by unpredictable symptom flares, involving both pain and non-pain symptoms that affect the gastrointestinal (GI)...
Abstract 4338384: Cardiovascular and Kidney Events Associated with Hypertension Screening Algorithms Among Young and Middle-Aged Adults
Introduction: Multiple screening algorithms exist for detecting undiagnosed hypertension, but hypertension-related outcomes across algorithms are unexplored, limiting universal imp...
Abstract 4367631: Hemodynamics and Extracardiac Causes of Cardiac Tamponade: A Diagnostic and Therapeutic Dilemma
Background: Cardiac tamponade is a known hemodynamic complication of pericardial effusion. However, other less recognized etiologies can produce similar physiologic findings and re...
Abstract 4368201: Education and Household Income Are Associated with Incident Venous Thromboembolism: The Atherosclerosis Risk In Communities Study
Introduction: Venous thromboembolism (VTE) is associated with morbidity and mortality. Emerging evidence suggests that social factors may influence VTE risk through pathways like b...
Abstract 4363406: Impact of Global Longitudinal Strain on Event-Free Survival Time of Patients with Heart Failure
Introduction: Left ventricular global longitudinal strain (GLS) is a known independent predictor of mortality and hospitalization in heart failure (HF). Nonetheless, the impact of...
Abstract 4363507: Higher Blood Pressure Time-in-Target Range May Improve Primary Cardiovascular Outcome in Patients with Hypertension and Coronary Artery Disease
Introduction: Higher blood pressure Time-in-Target Range (BP-TTR) has been associated with lower risk of cardiovascular outcomes. However, the prognostic value of BP-TTR among pati...
Abstract 4370945: Antithrombotic Strategies for Stroke Prevention in Elderly Patients with Atrial Fibrillation: A Meta-Analysis of Contemporary Evidence
Background: Optimal anticoagulation in non-valvular atrial fibrillation (AF) remains critical to minimizing stroke and systemic thromboembolism. While direct oral anticoagulants (D...
Abstract 4368600: Impact of Atrial Fibrillation on Outcomes in Patients with Hypertensive Emergencies: A National Inpatient Analysis
Background: Hypertensive emergencies (HE) are one of the frequent causes of emergency visits and are associated with significant morbidity and mortality. Limited data exist on how...
Abstract 4368119: Sex Differences in Myocardial Oxygen Supply-Demand Balance After Chronic Nicotine-Free E-Cigarette Exposure
Introduction: Myocardial ischemia results from an imbalance between oxygen supply and demand, typically affecting the subendocardium. The diastolic pressure time index (DPTI) and s...