Circulation
Articles in this Issue
Abstract 4367951: Hydatid Cyst in the Right Ventricle leading to Tricuspid stenosis and Heart Failure– A Case Report
Background: Cystic hydatid infection is a parasitic disease caused by the larval stages of Echinococcus granulosus, most commonly involving the liver and lungs. Cardiac involvement...
Abstract 4354094: Using Mixed Methods Research to Address Stagnant Mortality Rates in Congenital Heart Surgery
Background: New perspectives are needed to break the stagnant 2.7% operative mortality rate in congenital cardiac surgery. After experiencing a 0% operative mortality rate for 365...
Abstract 4367678: Network Analysis of Perceived Stress and Sleep Quality in Older African American Women: From the RiSE Study
Introduction: Older African American women experience high levels of psychosocial stress, which are associated with poorer sleep quality. Both factors contribute to elevated cardio...
Abstract 4364810: Contemporary Trends in Total and Low-Density Lipoprotein Cholesterol Among Young Adults in the United States, 2005–2024
Background: Cholesterol levels in early adulthood are a key determinant of lifetime cardiovascular risk, yet young adults are often overlooked in screening and prevention efforts....
Abstract 4371255: The Role of Myocardial Histological Remodeling in Exercise Intolerance Among Patients with Heart Failure with Preserved Ejection Fraction
Introduction: Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), and while myocardial histopathologic findings have been reported, they h...
Abstract 4369188: Mechanical Augmentation of the Failing Heart Results in Improved Intraventricular Synchrony Without Blood Contact
Purpose: Direct Mechanical Ventricular Actuation (DMVA) provides both systolic and diastolic augmentation to the failing heart without blood contact. The device uniquely augments d...
Abstract 4357525: Utility of Polygenic Risk Scores at Identifying Subgroup with Greater Benefit From Statins
Background: Coronary Artery Disease (CAD) is a complex heterogeneous disease with the greatest mortality and morbidity burden. While statins have been standard of care to reduce ri...
Abstract 4361924: Right heart dimensions and pulmonary arterial wedge pressure in pulmonary arterial hypertension: exploring a controversial relationship
Introduction: Pulmonary capillary wedge pressure (PCWP) provides an indirect estimate of left ventricular (LV) end-diastolic pressure.Its assessment is crucial in evaluating pulmon...
Abstract 4371326: Novel Role of Copper Transporter CTR1 in VEGF-C-induced VEGFR3 Signaling and Lymphangiogenesis
Background: VEGF-C is a central regulator of lymphangiogenesis, the formation of new lymphatic vessels, by binding to VEGFR-3 on lymphatic endothelial cels (LECs), triggering signa...
Abstract Sun1402: Fatal Pulmonary Embolism Following Intravascular Cooling for TTM in a Young Cardiac Arrest Survivor
Case Presentation: A 38-year-old male with a history of GERD and nicotine vaping suffered a witnessed out-of-hospital cardiac arrest. CPR was initiated immediately, and EMS arrived...
Abstract 4367902: Artificial Intelligence-Based Inference of Tissue Activation in Atrial Fibrillation from Noisy Clinical Electrograms
Background: Mapping of atrial fibrillation (AF) remains challenging and has not consistently improved ablation. A common problem, recognized by Galappasinge and Gray, de Groot, and...
Abstract 4373591: PREVENT in the 75-and-older population and additional prognostic value of coronary artery calcium: the Atherosclerosis Risk in Communities (ARIC) study
Background: The American Heart Association recently released the Predicting Risk of cardiovascular disease EVENTs (PREVENT) equation for estimating cardiovascular disease (CVD) ris...
Abstract 4365331: Muscle Matters: CT-Derived Skeletal Muscle Mass Is Independently Associated with Lower Cardiovascular Risk and Potentiates Exercise Benefit
Background: Diminished skeletal muscle mass predicts frailty and mortality, yet its independent association with major adverse cardiovascular events (MACE) and its interplay with p...
Abstract 4359705: Glucagon-like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors Reduce Dementia Risk in Type 2 Diabetes: A Comprehensive Bayesian Network Meta-Analysis
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) are cardioprotective glucose-lowering therapies, but their...
Abstract 4345917: Trends in Atherosclerotic Cardiovascular Disease Events in Patients with Type 2 Diabetes Mellitus: An Insurance Claims-Based Review
Introduction: Type 2 diabetes mellitus is a prevalent global disease (T2D). Patients have an increased risk of suffering from atherosclerotic cardiovascular disease (ASCVD). The ri...
Abstract 4365060: Rising Mortality at the Crossroads of Endocrine and Cardiovascular Disease: National Trends in Hyperthyroidism and Hypertension (1999–2020)
Background: Hyperthyroidism and hypertension are interrelated endocrine and cardiovascular disorders associated with significant morbidity and risk of complications. Despite their...
Abstract 4360588: Population Genomic Screening for Familial Hypercholesterolemia is Associated with Improved Lipid Management and Control
Background: Familial hypercholesterolemia (FH) is characterized by lifelong elevated LDL-cholesterol (LDL-C) and high risk of early-onset cardiovascular disease. Population genomic...
Abstract 4373273: Purulent Pericarditis in Austrian Syndrome: A Rare Case with Tamponade Physiology
Introduction: Austrian Syndrome is a rare, life-threatening triad of pneumonia, meningitis, and endocarditis caused by Streptococcus pneumoniae, typically in immunocompromised or a...
Abstract 4357466: Effect of Combination Therapy With GLP-1 Receptor Agonists and SGLT2 Inhibitors on Cardiovascular Outcomes in Type 2 Diabetes and ASCVD: A Systematic Review and Meta-analysis
Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) have each independently demonstrated significant cardiovasc...
Abstract 4365360: Trends in Mortality Involving Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease Among Adults in the United States, A 25-Year National Mortality Analysis (1999-2023)
Introduction: Pulmonary hypertension (PH), a progressive and life-threatening disorder, is often associated with chronic obstructive pulmonary disease (COPD). This combination wors...
Abstract Sun507: Artificial Intelligence Driven Subphenotyping of In-Hospital Cardiac Arrest Patients Identifies Subgroups with Different Outcomes and Risk Factors: A Nation-Wide Analysis
Introduction: Disparities in outcomes after in-hospital cardiac arrest (IHCA) across race, ethnicity, and socioeconomic status are impacted by social determinants of health (SDOH)...
Abstract 4371492: When Genes Collide: Hypertrophic Cardiomyopathy and Neurofibromatosis Type 1
Background: Hypertrophic cardiomyopathy (HCM) links to mutations in sarcomeric genes; however, evidence indicates overlap with RASopathies, particularly Neurofibromatosis Type 1 (N...
Abstract 4369502: Identifying optimum ECG features to predict sudden cardiac arrest at varying time points before the event
Background: Prediction of sudden cardiac arrest (SCA) from the ECG is of great importance, but is complicated by the uncertainty introduced by dynamic remodeling of the ECG over ti...
Abstract 4368545: Association Between Blood Pressure and Clinical Events in Peripheral Artery Disease with Small Vessel Disease
Background: Intensive blood pressure (BP) control reduces the risk of cardiovascular (CV) events, yet we recently reported a U-shaped association between BP and limb events in peri...
Abstract 4371324: Frequency and Outcomes of Intentional Non-Therapy for Infants Identified with Genotype-Positive Long QT Syndrome Following Cascade Testing
Background: Current guidelines recommend prophylactic beta-blocker therapy for all genotype-positive newborns with long QT syndrome (LQTS), despite the potential for QT normalizati...