Circulation
Articles in this Issue
Abstract 4365808: Cardiovascular Impact of Serious Mental Illness in Obstetric Patients: Insights from the Nationwide Inpatient Sample (2020-2022)
Introduction: Serious mental illness (SMI), defined as schizophrenia, major depressive disorder, or bipolar disorder, has been associated with an increased risk of a variety of adv...
Abstract 4368030: Impact of Timing and Pattern of Diagnosis on Outcomes in Cardiac Sarcoidosis Patients Undergoing Heart Transplantation: A Meta-Analytic Perspective
Background: Cardiac sarcoidosis (CS) is a rare but increasingly recognized indication for heart transplantation (HTx). While current guidelines include CS in transplant considerati...
Abstract 4364768: Functional Roles of Chronic Psychosocial Stress in Brain-Heart Interactions and Cardiac Autonomic Control in Male and Female Mice
Introduction: Chronic psychosocial stress (CPSS) is a well-known risk factor for depression and anxiety disorders and a significant risk factor for cardiovascular disease. CPSS has...
Abstract 4366155: Stroke Volume Work Index from speckle tracking is associated with mortality in critically ill patients with sepsis and septic shock.
Introduction: Septic shock is a common and often lethal disease. Myocardial dysfunction is a frequent complication in patients with septic shock. Common methods of assessing cardia...
Abstract Sat902: Surrogate-Researcher Dyad Consent Experience for Participation in a Cardiac Arrest Clinical Trial: A Multicenter Qualitative Study
Introduction/background: Surrogate informed consent for emergency research poses unique challenges which are not well defined....
Abstract 4365843: Closing Prevention Gaps in Women’s Heart Health: Real-World Impact of a Scalable Group Virtual Care Model
Introduction: Cardiovascular disease (CVD) is the leading cause of death for women in the United States, yet prevention gaps persist due to provider shortages, underrecognition of...
Abstract 4367240: Rab9-dependent Mitophagy is a Comprehensive Therapeutic Target for Cardiovascular Senescence, Atherosclerosis and Sarcopenia in Postmenopausal Women
Background: Menopause is a risk factor for atherosclerosis, heart failure, and sarcopenia in women. Although these age-related diseases are interrelated, there is no comprehensive...
Abstract 4368108: The Human Heart Atlas: An Integrative High-Resolution Multi-Omics Pipeline to Discover Novel Therapeutic Targets in Heart Failure
Research Question: Can an integrative, high-resolution multi-omics approach focused on the human myocardium identify potential therapeutic targets by mapping specific molecular and...
Abstract Sun204: Artificial Oxygen Carrier (HbV) Ameliorates Prognosis through Persistently Improving Arrhythmogenicity, LV dysfunction, Systemic Organ Damages in Hemorrhagic Shock during Pneumonectomy
Perioperative hemorrhagic shock (HS) is fetal in thoracic surgery. We previously reported acute salutary effects of Liposome-encapsulated hemoglobin vesicle (HbV) on organ dysfunction, hemodynamic det...
Abstract 4369721: Cultural Identity and Cardiovascular Risk Factors in South Asian Young Adults in the United States: The MASALA-2G Second Generation Study
Introduction: South Asian populations experience excess atherosclerotic cardiovascular disease (ASCVD) risk. Social determinants of ASCVD risk factors in second generation, young a...
Abstract 4371560: Obicetrapib in Patients with Dyslipidemia with or without Atherosclerotic Cardiovascular Disease Risk: A Meta-Analysis of Randomized Controlled Trials
Background: Guideline-directed lipid-lowering still leaves up to one-third of high-risk patients above LDL-C targets, sustaining residual cardiovascular risk. Obicetrapib—an oral c...
Abstract 4345869: Self-Monitoring And Responsive Technology for postpartum blood pressure control (SMART postpartum BP program): A Feasibility Study
Background: Hypertensive disorders of pregnancy (HDP) affect 15% of pregnant individuals and contribute significantly to maternal morbidity and mortality. Recent work in the U.K. s...
Abstract 4366874: AI-Based Cardiac Chamber Volumetry from CAC CT Enhances Heart Failure Prediction Beyond PREVENT-HF
Background: Coronary artery calcium (CAC) CT scans are widely used for the assessment of atherosclerosis, but their application for cardiac chamber volumetry in heart failure (HF)...
Abstract Sat1102: Capillary Refill Time and Transcutaneous to Arterial Carbon Dioxide Gap Are More Sensitive Than Lactate in Reflecting Hemodynamic Changes During Early Resuscitation of Septic Shock
Introduction: Septic shock is defined by systemic hypotension, tissue hypoperfusion, and elevated lactate levels. Although lactate is widely used to assess tissue oxygenation, it m...
Abstract 4370047: Creation of U.S. Population-Based, Age- and Sex-Specific Percentile Reference Standards for Atherogenic Lipid Measurements
Background: Atherogenic lipid concentrations (non-HDL-C, LDL-C, and apoB) typically increase during young adulthood. However, “normal” ranges used in clinical care are derived from...
Abstract 4347070: Pericardial Adipose Tissue Drives Cardiac Remodeling in Obesity via Lipolysis-Dependent Macrophage Modulation
Background: Obesity is a major risk factor for heart failure (HF). Recent clinical studies suggest an association between pericardial adipose tissue (PeAT) volume and HF, yet the u...
Abstract 4371518: Vitrified Partial Heart Transplants Grow at the Same Rate as Fresh Partial Heart Transplants and Retain Viable Donor Cells In-Vivo
Introduction: Partial Heart Transplants (PHT) retain shortcomings intrinsic to transplantation, including the requirement to transplant grafts urgently after donation to maintain c...
Abstract 4336917: Cardiovascular Risk in Patients with Multiple Sclerosis: A 10-year Matched Cohort Study
Background: Cardiovascular disease is a leading cause of morbidity and mortality worldwide, but its risk among patients with multiple sclerosis (MS) remains underexplored. This stu...
Abstract 4364510: Impella Support in Acute Severe Mitral Regurgitation With Cardiogenic Shock and Septal Injury–Related Heart Block
Background: Acute severe mitral regurgitation (MR) is a rare but life-threatening cause of cardiogenic shock, often resulting in multi-organ failure. Mechanical circulatory support...
Abstract 4340786: Autonomic inflexibility in Response to Mental Stress in Women with Coronary Microvascular Dysfunction: A Pilot Study
Background: Many women with chest pain suspected of having myocardial ischemia have no obstructive coronary artery disease (oCAD) but instead demonstrated coronary microvascular dy...
Abstract 4367432: Impaired Peak VO <sub>2</sub> at 3 Months Post-Acute Pulmonary Embolism is Independently Associated with Subsequent Development of Chronic Thromboembolic Pulmonary Hypertension
Introduction: Exercise limitation, commonly assessed by peak VO 2 , affects over 50% of acute pulmonary embolism (APE) survivors. Chronic th...
Abstract 4366285: Donor Renal Function Should Inform Evaluation of Circulatory Death Heart Offers
Background: Donation after circulatory death (DCD) is the fastest-growing source of donor hearts in the United States, yet the impact of donor hypertension, diabetes mellitus, and...
Abstract 4363195: Documentation Time, System Integration, and Workflow Challenges in Cardiology: A Clinician Survey
Background: US Cardiologists face increasing documentation burdens due to the use of multiple fragmented digital systems, including EHRs, imaging archives and cardiovascular-specif...
Abstract 4369864: Mapping the Burden: Racial and Social Vulnerability Clusters in Elderly Ischemic Heart Disease Related Mortality Across US Counties
Background: Ischemic heart disease (IHD) remains a leading cause of death in the United States, with disproportionate mortality among racially and socially marginalized groups. Thi...
Abstract 4369289: Clinical efficacy of Interleukin Antagonist therapy in pericarditis: A Systematic review and meta-analysis
Introduction: Pericarditis, an inflammation of the pericardium is estimated to affect about 27 in 100000 people every year. Interleukin antagonists are molecules that block the act...