Circulation
Articles in this Issue
Abstract 4372624: Seipin-Adipogenin Complex Drives Lipid Accumulation
Lipid metabolic abnormalities are associated with the incidence of the various cardiovascular diseases. Here, we identify that a novel seipin-Adipogenin complex plays a vital role in maintaining lipid...
Abstract 4364048: Ambient PM2.5 Exposure and Atrial Fibrillation Burden in the United States, 2000–2021: An Ecological State-Level Analysis
Background: Fine particulate matter (PM2.5) is increasingly recognized as a cardiovascular risk factor, with both short- and long-term exposure associated with higher rates of atri...
Abstract 4338972: Geographic Disparities in Female Mortality Due to Cardiac Arrhythmias: The Role of State Wealth, Healthcare Infrastructure, and Training Institutions
Background: Female mortality from cardiac dysrhythmias shows striking geographic variation across the U.S., yet the structural drivers of this disparity remain underexplored. Healt...
Abstract 4369369: Sex Differences in GLP-1 Receptor Mediated Effects on Exercising Blood Pressure Responses in Peripheral Artery Diseas
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are currently prescribed for diabetes and obesity and may also have beneficial effects for atherosclerotic condition...
Abstract 4364445: Novel β-MYH7 mutations Causing HCM among Indians
Background: Mutations in the β-MYH7 gene are a leading cause of unexplained left ventricular hypertrophy with abnormal loading conditions, w...
Abstract 4364317: Macrophage GPR68 Promotes Cell Infiltration and Collateral Arteriole Growth after Acute Myocardial Infarction
Background: GPR68, a mechanosensor and pH sensor, responds to shear stress and acidification and regulates mesenteric arteriole remodeling in response to pathological blood flow ch...
Abstract 4340229: Buccal epithelium protein map changes precede clinical manifestation of arrhythmogenic cardiomyopathies
Background information: Arrhythmogenic cardiomyopathies (ACM) account for >10% of sudden cardiac deaths (SCD) in the paediatric population. There is urgent need to drastically i...
Abstract 4364465: CRRL191: A Novel Bioengineered GC-A Peptide Agonist that Promotes Lipolysis and Insulin Secretion in Human Adipocytes and Pancreatic Beta Cells In Vitro
Background: The cardiac hormone atrial natriuretic peptide is the endogenous ligand for the guanylyl cyclase A (GC-A) receptor. The ANP/GC-A/cGMP pathway is a key regulator of card...
Abstract 4372395: Post-LVAD Pulsatility Index Trajectories and Their Clinical Implications: A Retrospective Study of China Multicenter LVAD Cohort
Introduction: Left ventricular assist devices (LVAD), widely adopted internationally, have been increasingly implemented in China as a vital life-support strategy for patients with...
Abstract 4356974: The Impact of Comorbidity Burden and Socioeconomic Status on Hospital Outcomes in Hypertrophic Cardiomyopathy Across Age Groups
Background: Age-related differences in comorbidity burden and social determinants of health may influence outcomes in patients with hypertrophic cardiomyopathy (HCM), yet these rel...
Abstract 4347149: Role of Ketone Body Metabolism in MASLD Progression and Pemafibrate Efficacy
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing globally due to rising obesity and metabolic syndrome. MASLD can progress to MASH, cirrho...
Abstract 4358612: The Jack Sarver Prize in Clinical Science: Aspirin Prophylaxis for Preeclampsia Prevention in Nigeria: A Mixed Methods Study
Background: More women die in Nigeria around the time of childbirth than in any other country in the world and preeclampsia is a leading cause of these deaths. Despite evidence-bas...
Abstract Sat803: Understanding Racial, Ethnic, and Socioeconomic Disparities in Bystander CPR Provision for Pediatric Out-Of-Hospital Cardiac Arrest in Philadelphia
Introduction: Pediatric out-of-hospital cardiac arrest (OHCA) survival remains low, with disparities in the provision of bystander CPR (BCPR). Prior studies suggest that comfort pe...
Abstract 4367579: Comparative Outcomes of Bivalirudin Versus Heparin in Cardiogenic Shock Patients Supported with Impella Device: A Propensity-Matched Multicenters Analysis
Backround: The optimal anticoagulation strategy in patients with cardiogenic shock (CS) undergoing mechanical circulatory support (MCS) with Impella remains an area of ongoing deba...
Abstract 4344908: Financial Burden in Cancer Survivors with Cardiovascular Comorbidities: A Nationwide Evaluation of U.S. Healthcare Expenditures and Utilization (2016–2022)
Background: Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in cancer survivors, yet its cumulative economic impact remains underexplored in national...
Abstract 4369891: Modeling the Early Effects of a Novel Intronic <i>LMNA</i> mutation in iPSC-Derived 3D Cardiac Organoids
Introduction: The LMNA gene encodes the nuclear envelope proteins Lamins A and C, which are essential for nuclear structure and function. Mu...
Abstract 4350638: Identification of the Autophagy-Related Gene ATF4 and Its Potential Mechanism in Dilated Cardiomyopathy
Background: Dilated cardiomyopathy (DCM) is a major cause of heart failure, characterized by ventricular dilation and reduced systolic function. Autophagy has been increasingly imp...
Abstract 4359996: Systemic Neutralization of Granulocyte-Macrophage Colony-Stimulating Factor Attenuates Stellate Ganglion Neuroinflammation and Cardiac Sympathetic Overactivation in Chronic Heart Failure
Background: Chronic heart failure (CHF) is marked by cardiac sympathetic overactivation, a critical driver for ventricular arrhythmogenesis and sudden cardiac death. Much evidence...
Abstract 4368424: CAUGHT IN THE NET: A RARE CASE OF MRSA ENDOCARDITIS OF THE CHIARI NETWORK
Here is a rare and diagnostically challenging case of infective endocarditis (IE) involving the Chiari network in a 47-year-old female with a complex cardiac and social history. She had a history of i...
Abstract 4362754: Macrophage Extracellular Traps Promote Maladaptive Cardiac Remodeling And Heart Failure Via PAD4-dependent Mechanisms
Background: The activation of inflammatory cells, particularly macrophages, plays a pivotal role in the pathogenesis of cardiac remodeling and failure. However, the precise mechani...
Abstract 4367570: A Case Report: Outpatient Diagnosis of Venous Stent Migration - Avoiding Catastrophic Outcomes
Intro: Peripheral venous stenting is an important treatment for iliocaval venous obstruction, but stent migration is a rare, serious complication with an incidence of 0.9–4.3% and...
Abstract 4373444: Transcatheter Versus Surgical Revascularization in Patients with Coronary Artery Disease and Aortic Stenosis: A Systematic Review and Meta-Analysis with Reconstructed Time to Event Data
Background: In patients with coexisting coronary artery disease (CAD) and aortic stenosis (AS), the comparative time-dependent event rates for percutaneous coronary intervention (P...
Abstract 4369077: Postoperative Inflammation Promotes HDL Dysfunction, Disrupting Reverse Cholesterol Transport and Driving Rapid Atherosclerotic Plaque Destabilization
Background: Myocardial Injury after Noncardiac Surgery (MINS) affects ∼1 in 6 patients undergoing major noncardiac procedures. A subset of MINS cases is linked to atherosclerotic p...
Abstract 4365733: Validation of a Non-invasive Machine Learning Algorithm to Assess Elevated Pulmonary Capillary Wedge Pressure at Point-of-Care
Introduction: Pulmonary capillary wedge pressure (PCWP), which reflects left ventricular filling pressure (LVFP), can only be reliably obtained using invasive right heart catheteri...
Abstract 4359395: Cardiac Function is Preserved in a Tissue-Engineered Model of LGMD2B
Background: Loss of dysferlin results in the rare, currently untreatable muscular dystrophy known as Limb Girdle Muscular Dystrophy 2B (LGMD2B). In LGMD2B mice, skeletal muscle und...