Circulation
Articles in this Issue
Abstract 4368957: Genome-wide in vivo identification of fitness factors for streptococcal infective endocarditis
Infective endocarditis (IE) is a life-threatening infection of the heart’s inner lining that remains difficult to treat and prevent, especially in individuals with preexisting cardiac conditions. Majo...
Abstract 4373485: Plasma proteomics associated with diastolic reserve: The Dallas Heart Study
Introduction: Impairments in cardiac diastolic reserve during physiological stress characterize HFpEF and may antecede resting state abnormalities. Biomarkers associated with cardi...
Abstract 4369346: Comparative effects of Single-Pill Combinations on Arterial Stiffness and Central Blood Pressure: A Randomized Trial in Indian Adults with Hypertension
I ntroduction: Arterial stiffness and central arterial pressure are independent predictors of cardiovascular morbidity and mortality, with central pressure offe...
Abstract 4373096: Inpatient Outcomes After Heart Transplantation With and Without LVAD Bridging
Introduction: Heart failure (HF) is one of the leading causes of hospitalization and mortality in the United States. Heart transplantation (HT) remains the definitive treatment for...
Abstract 4363189: Sleep Partially Mediates the Association Between Psychological and Cardiovascular Health Among Combat-exposed Service Members and Veterans
Background: Sleep disturbance is a common symptom of post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) and is associated with poor cardiovascular health (CV...
Abstract 4360950: Effect of perioperative benzodiazepine use on postoperative delirium in patients undergoing cardiac surgery: a systematic review and meta-analysis
Introduction: Cardiac surgery anesthesia is associated with risks such as postoperative delirium (POD) and stress-related responses. Benzodiazepines have been used perioperatively...
Abstract 4364424: Association Between PET-Defined Ischemia Severity and LVEF Improvement After PCI
Background: The benefit of percutaneous coronary intervention (PCI) in ischemic cardiomyopathy remains debated, particularly following the neutral REVIVED-BCIS2 trial. We evaluated...
Abstract 4358554: Coronary Artery Calcium Predicts All-cause and Non-coronary Mortality
Background: Coronary artery calcium (CAC) is a strong predictor of coronary artery disease (CAD) risk, and CAC=0 is a highly favorable prognostic marker. Recently, the prognostic v...
Abstract 4360993: Phenotypic Sex-Based Differences in Left Ventricular Geometry in Chronic Aortic Regurgitation
Background: Chronic Aortic Regurgitation (AR), a prevalent form of valvular heart disease, is associated with significant mortality and morbidity if left untreated. Emerging studie...
Abstract 4366659: Trends and Racial Disparities in Non-Ischemic Cardiomyopathy Mortality among Older Adults in the United States: A Population-Based Retrospective Study in the United States from 1999-2020
Background: Non-Ischemic Cardiomyopathy accounts for significant portion of cardiomyopathy with prevalence of about 15% in the community. Non-Ischemic cardiomyopathy (NICM) is a co...
Abstract 4372981: Senescence Gene Signatures Predict Response to SGLT2 Inhibitors in Heart Failure with Preserved Ejection Fraction: A Systematic Review and Transcriptomic Meta-Analysis
Background: Cellular senescence, a hallmark of aging and heart failure with preserved ejection fraction (HFpEF), is implicated in myocardial fibrosis, inflammation, and metabolic r...
Abstract 4342016: Prenatal activation of the G protein-coupled estrogen receptor (GPER) improves placental oxygenation and enhances offspring cardiac function in preeclampsia.
Introduction: Preeclampsia (PE) is a pregnancy disorder linked to placental dysfunction and long-term cardiovascular risk in the offspring. While activation of the G protein-couple...
Abstract 4367615: The Cardiovascular Paradox of Gout Prophylaxis: A Systematic Review and Meta-analysis
Introduction: Colchicine and NSAIDs are commonly used as flare prophylaxis during urate-lowering therapy (ULT) in gout, a chronic inflammatory condition linked to elevated cardiova...
Abstract 4360161: Atrial Fibrillation Ablation Outcomes by Hospital Academic Status: A Nationwide Comparative Analysis using TriNetX Registry
Background: Atrial fibrillation (Afib) is the most prevalent arrhythmia worldwide and catheter ablation has been established as an effective treatment modality. The outcomes can va...
Abstract 4370064: Cardioembolic Stroke in MELAS Treated with Thrombolysis
Background: MELAS is a rare mitochondrial disorder characterized by multisystem involvement, including stroke-like episodes, seizures, and cardiomyopathy. Cardiac involvement in ME...
Abstract 4367256: Improving Underserved POCUS Access Through Curriculum Strategies and Innovations
Introduction: Cardiac imaging, including CT, MRI, angiography, often involves complex procedures and extensive training not easily available in resource-limited areas. Nevertheless...
Abstract 4361616: Deglycosylation Enhances Performance of Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels for Acute Decompensated Heart Failure Diagnosis
Introduction: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker associated with incident acute heart failure. However, its diagnostic utility ma...
Abstract 4369842: A Growing Burden of Electronic Medical Record Messages in ACHD Care
Background: The rapid growth in the adult congenital heart disease (ACHD) population has led to an associated increase in the volume of patient visits at congenital heart centers....
Abstract 4348488: Multivalvular Disease in TAVR: The Impact of Non-Rheumatic Mitral Stenosis on Procedural Outcomes from the National Inpatient Sample 2020-2022
Introduction: Concomitant mitral stenosis (MS) is prevalent in ~10-15% of patients undergoing transcatheter aortic valve replacement (TAVR). There has been conflicting literature o...
Abstract 4349790: Association of Delayed Diagnosis of Transthyretin Cardiomyopathy with Heart Failure Hospitalizations and Mortality
Background: Timely diagnosis of transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is important for early treatment, which can improve outcomes....
Abstract 4373088: Genomic Insights into Incretin-Based Therapeutics for Peripheral Arterial Disease
Background: Peripheral arterial disease (PAD) is a major cause of morbidity and mortality, particularly in type 2 diabetes mellitus (T2DM). Current treatments for diabetic PAD pati...
Abstract 4363126: Systemwide Implementation of Bridge Clinics Reduces Readmissions and Hospital Utilization in Urban and Rural Heart Failure Populations
Background: Heart Failure (HF) is a leading cause of 30-day readmissions (20-25% nationally). Interdisciplinary Bridge Clinics (BCs) improve continuity of care, reduce readmissions...
Abstract 4368889: Xuezhikang Improves Carotid Plaque Stability in Statin-Intolerant Patients with Mild Stenosis
Background: Carotid atherosclerosis is a significant risk factor for ischemic stroke, with plaque instability contributing to stroke risk regardless of stenosis severity. For patie...
Abstract 4353779: A novel Notch and WNT signaling mechanism contribute to pediatric DCM: a pathway to new therapeutics
Background: Idiopathic dilated cardiomyopathy (iDCM) in children is a life-threatening disease. Little is known about its cellular and transcriptional landscape, and the lack of di...
Abstract 4362650: Mortality Trends in Septicemia Among Adults with Infective Endocarditis in the U.S.: An Analysis Using CDC WONDER (1999–2023)
Background: Infective endocarditis (IE) is a life-threatening condition often complicated by septicemia, yet national mortality trends and disparities in IE-related septicemia deat...