Circulation
Articles in this Issue
Abstract 4368308: Lived Experiences of Sudden Cardiac Arrest Survivors: A Descriptive Phenomenological Study
Background: Sudden cardiac arrest (SCA) is a critical and unexpected event that disrupts survivors’ physical, psychological, and social well-being....
Abstract 4372007: Perioperative Electrophysiological Study in Repaired Tetralogy of Fallot Undergoing Pulmonary Valve Replacement: A Systematic Review
Background: Patients with repaired Tetralogy of Fallot (TOF) undergoing pulmonary valve replacement (PVR) are at increased risk of major adverse ventricular arrhythmias and related...
Abstract 4367262: Left Atrial Strain in Highly Fit Individuals with Hypertensive Response to Exercise
Introduction: High-volume endurance exercise has been linked to increased atrial fibrillation (AF) risk. High blood pressure response (HBPR) to exercise in these athletes may corre...
Abstract 4364201: Paradoxical Mortality Benefit but Increased Procedural and Ischemic Risk in Prediabetic Patients with Chronic Total Occlusion: A National Inpatient Sample Analysis (2016–2022)
Background: The impact of prediabetes on outcomes in chronic total occlusion (CTO) hospitalizations remains unclear. We evaluated the association between prediabetes and in-hospita...
Abstract 4373232: Toxicant-Mediated Pulmonary Hypertension in Southwest Asia Veterans
Chronic exertional dyspnea has been documented in US Veterans after deployment to Iraq and Afghanistan with reported environmental inhalation exposures. We studied whether continued exertional dyspnea...
Abstract 4344928: Mortality and Disease Burden of Smoking-Related Lower Extremity Peripheral Artery Disease: A Comparative Analysis of the U.S. and High Socio-Demographic Index Countries
Background: Peripheral artery disease (PAD) significantly contributes to cardiovascular morbidity. Smoking, a key modifiable risk factor, accelerates PAD progression and increases...
Abstract 4367562: Cardiac Amyloidosis Risk Across Ethnoracial and Clinical Subgroups: A 5-Year National Study
Background: Cardiac amyloidosis, a frequently underdiagnosed condition, involves amyloid fibril deposition in the heart, leading to progressive diastolic dysfunction in a nondilate...
Abstract 4358037: Barriers and Strategies in Neurovascular Care for Ruptured and Unruptured Intracranial Aneurysms During Awake Craniotomy: A Systematic Review
Background: Awake craniotomy for ruptured and unruptured intracranial aneurysms poses distinct neurovascular challenges. Identifying key barriers and strategies is essential to imp...
Abstract 4366144: From Gut to Lung: Lipoxygenase Dependent Oxylipin Amplification Drives 15-HETE Induced Pulmonary Hypertension in C57BL6/J Mice
Background: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease characterized by pulmonary vascular remodeling, increased right ventricular pressure, and event...
Abstract 4372936: King of Hearts: Effectiveness of a Card-Based Educational Tool for Electrocardiogram Teaching and Long-Term Retention in Medical Students
Background: Electrocardiogram (ECG) interpretation is a core competency in medical education, yet remains a difficult skill for preclinical students to acquire and retain through t...
Abstract 4362115: Lack of Genetic Ancestral Diversity is a Major Driver of Clinically Meaningful Changes in Variant Pathogenicity Classification for Reportable Cardiovascular Disease-associated Genes
Introduction/Background: Genetic heart disease encompasses potentially life-threatening conditions, necessitating accurate interpretation of genetic testing. Results range from dia...
Abstract 4367836: Trends and Disparities in Type 2 Diabetes Mellitus and Cardiac Arrest-Related Mortality Among Adults in the United States from 1999 to 2023.
Background: Type 2 Diabetes Mellitus (T2DM) is a major cardiovascular risk factor and growing contributor to sudden cardiac death. Despite growing awareness, the burden and trends...
Abstract 4354063: Purulent Pericarditis Leading to Cardiac Tamponade and Constrictive Physiology
Background: Purulent pericarditis is a rare, often life-threatening infection of the pericardial space, characterized by the accumulation of pus. Seeding of the pericardium may occ...
Abstract 4362779: Association Between Individual, Sociocultural, and Environmental Factors and Diet Quality Across Income Levels in Adults with Preclinical Heart Failure
Background: As heart failure (HF) becomes more prevalent, early intervention in its preclinical stages is essential to reduce morbidity and mortality. Heart-healthy diet adherence...
Abstract 4345063: Upf1 Lactylation Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Background: To identify the role of lactate and protein lactylation in promoting cardiomyocyte proliferation and to evaluate the therapeutic potential of lactylation-mediated regul...
Abstract Sat1404: Understanding the Factors Linked With Mortality Risk Among Patients With Out-of-hospital Cardiac Arrest Managed in the Intensive Care Unit
Introduction: At least three out of four patients hospitalized for out-of-hospital cardiac arrest(OHCA) will not survive their stay. Although the use of intensive care units (ICUs)...
Abstract 4358367: c-Rel–Mediated Lipid Accumulation and Inflammatory Activation in Monocytes in Hypertriglyceridemia
Background: Hypertriglyceridemia (HTG), with elevated triglyceride-rich lipoproteins (TRLs) and remnants, increases atherosclerotic cardiovascular disease (ASCVD) risk, but the mec...
Abstract 4363517: Higher visit-to-visit glucose and HbA1c variability are associated with lower gray matter and higher white matter hyperintensity volumes in older adults: The Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Dysglycemia is a well-established risk factor for cognitive decline. The association of long-term glucose control with early neuroimaging markers of dementia remains la...
Abstract 4361339: Resolvin D2 Inhibits Murine Thoracic Aortic Aneurysm Formation
Background: Inflammatory signaling and extracellular matrix (ECM) remodeling play crucial roles in the formation of thoracic aortic aneurysms (TAAs). D-series Resolvins, including...
Abstract 4367264: SGLT2 Inhibitors in Atrial Fibrillation Patients without Diabetes: A Propensity-Matched Analysis of Mortality and Cerebrovascular Outcomes
Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated cardiovascular benefits in patients with type 2 diabetes, including reduction in heart failure (HF)...
Abstract 4373150: Distinct Fibrochondrocyte Transdifferentiation Differentiate Thoracic Aortic Aneurysmal Remodeling from Atherogenesis
Introduction: Phenotype switching, a pathological process involving dedifferentiation, migration, and transdifferentiation into other cell types—particularly fibrochondrocytes—play...
Abstract 4364354: <i>CYP2C19-</i> Guided Therapy Antiplatelet Therapy Influences Outcomes After Percutaneous Coronary Intervention in Black Patients
Introduction: Cytochrome P450 2C19 ( CYP2C19 ) loss-of-function (LOF) genotypes reduce clopidogrel, but not prasugrel or ticagrelor, effecti...
Abstract 4367620: One Size Doesn't Fit All: Age-Stratified Analysis of Digital Health Readiness and Patient Portal Use in US Adults with Cardiovascular Disease from 2024 Health Information National Trends Survey
Background: Patient portals can support cardiovascular disease (CVD) management, but disparities in digital health readiness, especially among older adults, may limit their use. Un...
Abstract 4344839: Association Between Sleep Duration and Angina Characteristics in United States Adults
Background: Sleep is now recognized as a key factor in cardiovascular health by the American Heart Association’s Life’s Essential 8. To our knowledge, this study is the first to an...
Abstract 4359841: Patient-Reported Outcomes in Patients with Symptomatic, Obstructive Hypertrophic Cardiomyopathy Treated with Mavacamten: Real-world Observations through Week 30 from the COMPASS-HCM Study
Background: Clinical trials have demonstrated mavacamten’s efficacy in improving health status of patients with obstructive hypertrophic cardiomyopathy (oHCM), but real-world data...