Circulation
Articles in this Issue
Abstract 4371049: Pulsed-Field vs Radiofrequency Ablation: Evaluation of Outcomes in Recurrent Atrial Fibrillation
Background: Pulsed-field ablation (PFA) has recently been approved in the USA as a new method for treating atrial fibrillation (AF). PFA provides a promising new approach in the tr...
Abstract 4367228: Asymmetric Pulmonary Artery Geometry Drives Branch-Specific Shear Stress Patterns in Repaired Tetralogy of Fallot: A Substudy of the <i>Single Center Cardiac Magnetic Resonance Outcomes Registry – Tetralogy of Fallot</i>
Introduction: In repaired tetralogy of Fallot (rToF), asymmetric remodeling of the pulmonary arteries (PA) leads to branch-specific hemodynamic changes. Geometric factors such as c...
Abstract 4368593: Black Patients Have Higher Odds of Discharge with Wearable Cardioverter-Defibrillators
Background: The wearable cardioverter-defibrillator (WCD) is a an external, patient-controlled device that offers lifesaving protection against sudden cardiac death in patients wit...
Abstract 4362516: Therapeutic Targeting of Notch Signaling Rescues p.S13F-induced Desmin Cardiomyopathy
Background: Pathogenic DES mutations cause desmin cardiomyopathy (DesCM), characterized by desmin aggregation and intercalated disc dysfunct...
Abstract 4358694: Pulmonary Embolism Presenting with Classical S1Q3T3 Pattern on Electrocardiogram: Implications for Hemodynamic Instability
Background: Pulmonary Embolism is a potentially life-threatening condition that may present with a spectrum of ECG abnormalities. Among these, the S1Q3T3 pattern: a prominent S in...
Abstract 4368010: Noninvasive Assessment of Left Ventricular Pulsatile Workload Using Smartphone-Measured Carotid Waveforms
Introduction: Left ventricular pulsatile workload (LVPW) is a clinically established marker of cardiac afterload and function, and it is strongly associated with cardiovascular mor...
Abstract 4357583: Pulmonary Arterial Elastance as a Prognostic Marker for In-Hospital Mortality in STEMI With Cardiogenic Shock or Severe Heart Failure
Background: While early reperfusion therapy via PCI has significantly reduced mortality in STEMI patients, outcomes remain poor for those presenting with cardiogenic shock (CS) or...
Abstract 4369639: Pulmonary congestion assessment by automated quantitative computer tomography in heart failure patients
Introduction: Heart failure (HF) affects interstitial lung structure and function. AI-assisted quantitative computed tomography (qCT) offers possibility of objective assesment of l...
Abstract 4362686: Large-scale genome-wide association meta-analysis and proteome- and transcriptome-wide Mendelian randomization reveal novel therapeutic targets for heart failure
Background: Heart failure (HF) is a leading global cause of morbidity and mortality. Despite therapeutic advances, effective strategies for the primary prevention for HF are limite...
Abstract 4337128: Myc Induces Higher Cardiomyocyte Cell Cycle Activity and Protects Cardiac Function after Myocardial Infarction in Mice
Background: In adults, injured cardiomyocytes (CMs) rarely regenerate after myocardial infarction (MI), due to limited proliferation and cell cycle activity of CMs, impairing cardi...
Abstract 4361636: Prediction of Cardiovascular Disease Risk in Chinese Elderly from 2025 to 2050: A Simulation Study Based on a National Cohort
Background: Cardiovascular disease (CVD) has emerged as a leading chronic health threat among older adults. Anticipating the future trajectory of CVD incidence among the elderly an...
Abstract 4366016: Neighborhood Walkability is associated with ABIs and Quality of Life among Adults with Peripheral Artery Disease
Background: Regular walking is associated with improvements in physical function and quality of life among adults with peripheral artery disease (PAD). Neighborhood characteristics...
Abstract 4365782: Healthcare resource use (HCRU) and costs differ between those with and without follow-up LDL-C monitoring after newly initiating lipid lowering therapy (LLT)
Introduction/Background: Despite wide availability of safe and effective LLT to reduce LDL-C and prevent ASCVD events, LLT is underused. There is evidence that LDL-C monitoring rem...
Abstract 4358321: ECG-SMART: A Clinician-Guided AI Dashboard for Occlusion Myocardial Infarction Detection in the Emergency Department
Artificial Intelligence (AI)-driven ECG methods are transforming clinical workflows, signaling a shift in ECG analysis research and clinical practice. Adoption in routine care remains limited—largely...
Abstract 4359210: Temporal Trends and Differences in Hypertension-Related Atherosclerotic Cardiovascular Disease (ASCVD) Mortality in the United States, 2000–2021
Background: Hypertension is a major contributor to atherosclerotic cardiovascular disease (ASCVD), a leading cause of death in the United States. However, national trends in hypert...
Abstract 4367211: Impact of Histologic Fibrosis Patterns and Myocardial Involvement on Diastolic Dysfunction in Non-Dilated Cardiomyopathy
Background: Myocardial fibrosis is a key determinant of diastolic dysfunction in non-dilated left ventricular cardiomyopathy (ND-LVCM). However, the extent to which fibrosis burden...
Abstract 4366170: A Rare Association of Darier’s Disease and Dilated Cardiomyopathy: A Case Report Exploring the Cardiac Implications of ATP2A2 Mutation
Darier’s disease (DD) is a rare autosomal dominant dermatologic disorder caused by mutations in the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum C...
Abstract 4361396: Cardiometabolic Therapy Reduces Electrocardiogram-Derived Biological Age: A Time-Weighted Analysis
Background: Electrocardiogram-derived age is a novel biomarker generated using artificial intelligence that reflects physiological rather than chronological aging. A higher electro...
Abstract 4370866: Evaluating the potential for SPAR analysis of ECGs with time matched disease progression to create a remote disease monitoring tool for patients with ATTR-Cardiac Myopathy aiming to reduce patient burden by avoiding frequent complex imaging
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening condition, disease progression is currently measured using a combination of clinical, laboratory, M...
Abstract 4369853: Association Between Genetics Variants And Clinical Outcomes In Patients With Left Ventricular Assist Device
Introduction: Right ventricular failure (RVF) is a common complication following left ventricular assist device (LVAD) implantation, resulting in significant morbidity and mortalit...
Abstract 4369104: Polygenic Risk-Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials
Background: Coronary artery disease polygenic risk scores (CAD PRS) identify individuals at low clinical, but elevated genetic risk who may “fly under the radar” in contemporary pr...
Abstract 4358355: Impact of mavacamten on the rates of hospitalization and emergency room (ER) visits in patients with obstructive hypertrophic cardiomyopathy (HCM) in the United States
Background: Mavacamten has been shown to improve functional status and symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM) in both clinical trials and real-worl...
Abstract 4371648: Association Between Food Insecurity and Diagnoses of Cardiovascular Disease and Stroke: National Health and Nutrition Examination Survey (2005-2020)
Background: Cardiovascular disease (CVD), characterized by coronary heart disease (CHD) and congestive heart failure (CHF), remains a leading cause of morbidity and mortality world...
Abstract 4369507: Large Language Models for Patient Education for Atrial Fibrillation
Background: Large language models (LLMs) are used by patients seeking information about atrial fibrillation. More than 1 billion monthly users use 4 common LLMs: ChatGPT, Gemini, C...
Abstract 4371525: Mapping Inequity: Racial Disparities and Social Vulnerability Drive Sudden Cardiac Death Hotspots Across U.S. Counties
Background: Sudden cardiac death (SCD) is a leading cause of mortality in the U.S., with emerging evidence pointing to racial disparities and the impact of social vulnerability. Ye...