Circulation
Articles in this Issue
Abstract 4370391: Temporal Trends in Endocarditis-Related Mortality in Patients With Cardiac Device Complications in the United States, 1999–2023: A Joinpoint Regression Analysis
Background: Cardiac devices such as prosthetic valves, coronary bypass grafts, and implantable hardware have improved survival but are associated with increased infection risk. Inf...
Abstract 4364710: Association Between Pre-Operative History of Significant Bleeding and Post-Operative Cardiovascular Events Following Lower Extremity Revascularization
Background and Hypothesis: Patients with symptomatic peripheral artery disease (PAD) frequently undergo lower extremity revascularization (LER) but remain at increased risk of majo...
Abstract 4336675: Racial, Regional, Gender, and State-Level Disparities in Sudden Cardiac Death Mortality: An Analysis of Historical Trends and the rationale behind Shift in pattern in the U.S. Population Aged 44 to 85+ (1999–2020)
Background: Sudden Cardiac Death (SCD) may account for up to 20% of worldwide deaths. It mainly affects adults over 35, especially those with cardiac disease. Epidemiological trend...
Abstract 4364283: Proteomics Signatures of Systemic Sirolimus Therapy in Pediatric Pulmonary Vein Stenosis
Introduction: Pulmonary vein stenosis (PVS) is a rare disease associated with significant morbidity and mortality, and its underlying pathophysiology remains poorly understood. PVS...
Abstract 4368828: CUB domain-containing protein 1 Regulates Extracellular Matrix Remodeling and <i>Src</i> Kinase-Mediated Signaling in Human Cardiac Fibroblasts
Background: Cardiac fibrosis is a critical and independent driver of heart failure (HF), characterized by excessive extracellular matrix (ECM) deposition. Decreased...
Abstract 4361129: Beyond the Periphery: Coronary Endothelial Dysfunction as a Distinct Marker of Cardiovascular Risk in HIV
Background: People living with HIV (PLWH) have an increased risk of cardiovascular events compared to persons without HIV (PWoH), even with optimal control of their infection with...
Abstract 4360296: Beyond Antibiotics: Transcatheter AngioVac Debulking of Right-Sided Methicillin-Resistant Staphylococcus aureus Endocarditis in a Hemodialysis Patient
Background: Methicillin-Resistant Staphylococcus aureus (MRSA) infective endocarditis (IE) is a serious complication in hemodialysis patients with indwelling catheters, with mortal...
Abstract 4345080: HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2-driven Metabolic Reprogramming
Background: Neonatal heart possesses a unique ability to regenerate within seven days of birth. However, the adult mammalian heart is incapable of regeneration. The underlying rela...
Abstract 4370672: Geospatial Analyses Provide the Link Between Adverse Social Determinants of Health and Environmental Exposures to Heart Failure with Preserved Ejection Fraction Outcomes
Background: Medical care accounts for only 10% to 20% of overall health outcomes, while the majority are shaped by social determinants of health (SDoH), environmental exposures, an...
Abstract 4373324: Using Metabolomics to Identify Predictive Biomarkers for Thrombotic Complications in Patients with Left Ventricular Assist Devices
Background: End-stage heart failure patients undergoing left ventricular assist device (LVAD) implantation often face thrombotic complications (TC) such as pump thrombosis, venous...
Abstract 4343294: Left Bundle Branch Area Pacing Improves Mortality and Heart Failure Outcomes Compared to Right Ventricular Pacing in Atrioventricular Block: A Systematic Review and Meta-Analysis
Background: Left bundle branch area pacing (LBBAP) is an emerging physiologic pacing strategy that may offer advantages over conventional right ventricular pacing (RVP) in patients...
Abstract 4370891: Gender Matters in Heart Failure Caregiving
Background: Caregiving burden is known to be high. However, the burden and responsibilities of caregiving may not be equally distributed between male and female caregivers. Similar...
Abstract 4361269: Predictors of Mortality Among Hospitalized Patients with Repaired Congenital Heart Defects Following Catheter Ablation Procedures
Background: Repaired congenital heart defects poses an increased risk of mortality in patients undergoing catheter ablation. However, there is limited data on the factors associate...
Abstract 4365473: Cerebral embolic protection in Transcather Aortic Valve Replacement: An updated meta-analysis of 11692 patients
Background: We conducted an updated meta-analysis of the routine use of cerebral embolic protection (CEP) devices in Transcathter Aortic Valve Replacement (TAVR). This analysis fol...
Abstract 4373384: Suboptimal Sleep Associates with Heightened Stress-Related Neurobiological and Leukopoietic Activity: Mediating Pathways to Cardiovascular Disease in Humans
Background: Suboptimal sleep (Sleep SO )—due to insufficient duration or sleep disorders—is prevalent and linked to cardiovascular disease (...
Abstract 4369559: Systemic Lupus Erythematosus Exacerbates Cardiac and Renal Injury and Inflammation and Attenuates the Cardiac Type 1 Interferon Response in Female Mice
Background: Autoimmune diseases affect ~10% of the population, the overwhelming majority of which are women. However, the impact of autoimmune disease, such as systemic lupus eryth...
Abstract 4364366: Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin’s biochemical activity without changing thick filament structure
Introduction: Inhibiting contractility by targeting cardiac myosin is an effective treatment for patients with hypertrophic cardiomyopathy (HCM). Aficamten (Afi), a second in class...
Abstract 4369309: Mfge8/Integrin Signaling in Atherosclerotic Vascular Disease in Diabetes
Background: Mfge8 is an integrin ligand and a major exosome (EV) protein known to mediate inflammation and atherosclerosis in type 2 diabetes mellitus (T2DM) in animal research. Th...
Abstract 4373693: Support duration as a prognostic indicator in temporary MCS: divergent outcomes based on the 14-day FDA approved duration
Background: Impella 5.5 is a temporary MCS device FDA-approved for use up to 14 days. Limited data suggest it may be safe beyond this. We aim assess outcomes based on the duration...
Abstract 4363499: Mechanical Chest Compressions are Associated with Worse Outcomes When Compared to Manual Chest Compressions during In-Hospital Cardiac Arrests
Background: Early high-quality chest compressions in cardiopulmonary resuscitation (CPR) are critical to in-hospital cardiac arrests (IHCA). Studies report suboptimal CPR during IH...
Abstract 4353558: Loss of Phosphoglucomutase-1 (PGM1) Impairs Cardiac Glycolytic flux and Mitochondrial Function in Mice.
Background: Phosphoglucomutase 1 (PGM1) is essential for converting glucose 1-phosphate to glucose 6-phosphate, playing a pivotal role in glycolysis, glycogen metabolism, and glyco...
Abstract 4365831: GP73 Associates Causally with Incident Heart Failure through Insulin Resistance in Community-Dwelling Adults: The ARIC Study
Background: High fat diet induces GP73 secretion from the liver, heart and adipose tissue. GP73 promotes metabolic dysfunction and insulin resistance in preclinical studies, but wh...
Abstract 4363703: Both electrical isolation and lesion homogeneity should be focused: evidence from repeat atrial fibrillation ablation
Background: Recurrent atrial tachycardia (AT) remains a major challenge following catheter ablation for atrial fibrillation (AF). While pulmonary vein (PV) reconnection is a well-r...
Abstract 4364679: Endothelial ADAM17 is essential in recovery from myocardial infarction by limiting cell death, promoting vascularization and optimizing infarct formation
Introduction: Myocardial infarction (MI) is a leading cause of death worldwide, and endothelial cells (ECs) are central to the repair process by coordinating angiogenesis, immune c...
Abstract 4369033: Prolonged Trans-Valvular Unloading with an Impella CP for 6 hours Protects Against Myocardial Damage in Preclinical Models of Acute Myocardial Infarction
Acute myocardial infarction (AMI) is a major cause of mortality and heart failure worldwide. Reducing left ventricular (LV) workload using a trans-valvular pump (TVP) and delaying reperfusion reduces...