Circulation
Articles in this Issue
Abstract 4335947: Resistance Training and Risk of Type 2 Diabetes and Cardiovascular Disease in Women: A Prospective Cohort Analysis from the Nurses' Health Study
Background: Resistance training may help reduce the risk of chronic diseases, but evidence among women remains limited. Ob...
Abstract 4364886: The Association Between Tricuspid Regurgitation And Clinical Outcomes In Patients With Cardiac Amyloidosis
Background: Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy associated with poor prognosis. CA is commonly due to transthyretin (ATTR) or light chain (AL) amy...
Abstract 4367597: Temporal Trends of Contributing Cardiovascular Mechanisms of Mortality in Patients with Atrial Fibrillation Stratified by Age and Sex
Background: Atrial Fibrillation (AF) is a significant cause of cardiovascular morbidity and mortality risk. Age is a powerful predictor of adverse outcomes in patients with AF. In...
Abstract 4339322: SGLT2 Inhibitors and Long-Term Outcomes in Kidney Transplant Recipients: A Propensity-Matched Cohort Study
Background: Cardiovascular disease is a leading cause of morbidity and mortality among kidney transplant recipients, driven by traditional risk factors and immunosuppressive therap...
Abstract 4360298: Examining associations of medical discrimination and the hypertension cascade among adults in the All of Us Research Program
Background: Hypertension (HTN) is the leading risk factor for cardiovascular disease. Medical discrimination (i.e., discrimination in healthcare settings) is linked to poor disease...
Abstract 4348120: Mortality Trends and Disparities In Hypothyroidism and Ischemic Heart Disease in the United States from 1999 to 2020: A CDC WONDER Analysis
Background: Patients with ischemic heart disease and hypothyroidism face a higher risk of death compared to euthyroid individuals in the U.S. The relationship between Hypothyroidis...
Abstract 4366824: Protection of PDCD4 against doxorubicin-induced cardiotoxicity
Background: Programmed Cell Death 4 (PDCD4) is a tumor suppressor known for promoting apoptosis and inhibiting growth and protein translation in cancer cells. However, the role of...
Abstract 4365480: Geographic, Gender, and Age Disparities in Aortic Aneurysm Burden: Insights from GBD 2021 U.S. Dat
Background: Aortic aneurysm is a fatal but preventable cause of cardiovascular mortality. We used GBD 2021 U.S. data to analyze geographic, gender, and age disparities in death and...
Abstract 4339739: SGLT-2 Inhibitors in the Prevention of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis
Background: Chemotherapy is linked to significant cardiotoxicity. While guideline-directed heart failure therapies help mitigate these effects, the role of sodium-glucose cotranspo...
Abstract 4359184: Trends in Mortality Due to Heart Failure and Gastrointestinal Hemorrhage in the United States: A Retrospective Analysis of CDC WONDER Database
Introduction: Weakening of cardiac function in Heart Failure is clinically associated with Gastrointestinal Hemorrhage. This study investigates mortality trends to identify dispari...
Abstract 4365822: Alleviating radiation-induced cardiovascular disease with a radioprotective fullerene derivative
Despite modern radiation therapy (RT) advancements, radiation-induced cardiovascular (CV) disease remains a significant cause of morbidity and mortality among cancer patients. Reactive oxygen species...
Abstract Sat305: Race and Ethnicity Classification via Deep Learning Electrocardiogram Analysis
Background: Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. Demographics, including race/ethnicity, are among...
Abstract 4369836: Diagnostic Accuracy of AI Algorithms for Detecting Left Ventricular Diastolic Dysfunction on ECG: A Systematic Review and Meta-Analysis
Background: Left ventricular diastolic dysfunction (LVDD), a key precursor to heart failure with preserved ejection fraction, is frequently underdiagnosed using on routine electroc...
Abstract 4340497: Cardiopulmonary Resuscitation Coach Training with Modified Resuscitation Cart Improves Provider Knowledge and Perception of Pediatric Resuscitation Efficiency
Background: High-quality cardiopulmonary resuscitation (CPR) is critical for survival after pediatric cardiac arrest, yet adherence to guideline metrics and timely utilization of e...
Abstract 4360925: A phenomapping-informed machine learning tool estimates individualized cardiometabolic effects from Tirzepatide and generalizes to a new population.
Background: Tirzepatide induces weight loss (WL), but its precise use among those more likely to benefit from WL and experience cardiometabolic effects can enable more scalable dep...
Abstract 4372054: Pembrolizumab-Induced Myositis Unmasking Double M Syndrome with Smoldering Myocarditis
Background: Immune checkpoint inhibitors (ICIs), such as pembrolizumab, have revolutionized cancer therapy but can trigger immune-related adverse events (irAEs), including myocardi...
Abstract 4366192: Energy Insecurity Associates with Increased Odds of Cardiovascular Disease Risk Factors and Burden: Data from the Behavioral Risk Factor Surveillance System, 2023
Introduction: Over a quarter of US households experience energy insecurity (EI) - the inability to meet household energy needs - and this number is expected to rise due to increasi...
Abstract 4346602: Impact of Novel Genetic Variants of Thoracic Aortic Aneurysm and Dissection Derived from a Community Cohort Study in Yamagata, Japan, for Preventive Aortic Therapy
Background: Thoracic aortic aneurysms and dissections (TAAD) are primarily associated with acquired factors. However, 20% of cases exhibit familial clustering, indicating a genetic...
Abstract 4367078: The Association between Non-High-Density Lipoprotein Cholesterol Level and Coronary Fatty Plaque Regression
Background: Regression of coronary fatty plaque, the type most prone to rupture and cause acute coronary syndromes, is associated with fewer cardiovascular events. A baseline non-H...
Abstract 4368894: The efficacy of computerized cognitive training in patients with coronary heart disease and cognitive impairment, no dementia: a randomized controlled trial (COG-T CHD)
Background: Adaptive digital therapy can improve the effect of cognitive training compared to traditional methods, but there is no related evidence in patients with coronary heart...
Abstract 4373218: Safety and Efficacy of Moderate-Intensity Statin Plus Ezetimibe versus High-Intensity Statin in Older Adult Patients: A Meta-analysis
Introduction: Guidelines recommend high-intensity statin treatment for achieving target low-density lipoprotein cholesterol (LDL-C) levels in high-risk patients. Nonetheless, moder...
Abstract 4361559: Optimal Medical Therapy and Uncontrolled Risk Factors in Patients with Chronic Coronary Syndrome Undergoing PCI: Temporal Trends and Clinical Outcomes
Background: Despite guidelines recommending revascularization for refractory angina after optimal medical therapy (OMT) in chronic coronary syndrome patients (CCS), limited studies...
Abstract 4366819: Clinical outcomes in patients with early right ventricular failure during index admission after HeartMate 3 LVAD implantation
Background: Despite the survival benefit of durable left ventricular assist devices (LVAD) in patients with end stage heart failure, right ventricular failure (RVF) remains a promi...
Abstract 4370846: Real-World Outcomes of Inclisiran vs. Ezetimibe in Statin-Treated Coronary Artery Disease Patients: A 1-Year Observational Analysis
Background: Residual risk of adverse cardiovascular events remains high among patients with coronary artery disease (CAD) despite high-intensity statin therapy. Although ezetimibe...
Abstract 4368934: Bachmann’s bundle-related atrial tachycardias following catheter ablation of persistent atrial fibrillation
Background: Atrial tachycardias (AT) after radiofrequency ablation (RFA) of atrial fibrillation (AF) may utilize Bachmann’s bundle (BB). Due to their epicardial location, these ATs...