Circulation
Articles in this Issue
Abstract 4372975: Burden of Anemia Due to Hypertensive CKD from 1990-2021: A Growing Global Crisis Extending from Low-Income Regions to the United States
Background: Chronic kidney disease(CKD) is a growing global health challenge, with hypertension being a leading cause of renal dysfunction across populations. A major yet underreco...
Abstract 4359544: Evaluating the Association Between Statin Use and New-Onset Diabetes in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
Rationale: Statins are widely used in renal transplant recipients to optimize the cardiovascular risk and improve the outcomes. However, concerns have emerged regarding the potenti...
Abstract 4345057: CCL2 Aggravates Thrombosis by Upregulating Platelet P2Y12 Receptor via CCR2: Mechanisms and Therapeutic Implications
Introduction: The P2Y12 receptor mediates platelet aggregation, but current therapies (e.g., clopidogrel) face interindividual variability and resistance. While CCL2 may regulate p...
Abstract 4369472: Impella-Induced Aortic Regurgitation diminishes the effectiveness of Impella support at a clinically typical afterload: Insights from a Pulsatile Mock Circulation Model
Background: The Impella device provides percutaneous left ventricular support but may induce aortic regurgitation (AR) due to its transvalvular placement. In this study, we defined...
Abstract 4367784: Use of Protamine to Mitigate Bleeding Risk Following Transcatheter Aortic Valve Implantation; A Systematic Review and Meta-analysis.
Background: Bleeding is a major concerns during transcatheter aortic valve implantation (TAVI). Protamine is routinely used to reverse unfractionated heparin, but its overall safet...
Abstract 4370303: Sacubitril / Valsartan Lowers Ventricular and Atrial Arrhythmia Risk in Heart Failure: Systematic Review and Meta-analysis
Background: Sacubitril /valsartan, an angiotensin-receptor–neprilysin inhibitor (ARNI), improves survival in heart failure, yet its impact on clinically significant arrhythmias rem...
Abstract 4348051: Adherence to Guideline-Directed Oral Anticoagulant Therapy in Patients with Atrial Fibrillation and Atrial Flutter Admitted in a Tertiary Private Hospital: A Retrospective Study
Background: Atrial fibrillation (AF) is associated with an increased risk of thromboembolism. Atrial Flutter (AFL) has s imilar risk factors as AF and many of these patients eventu...
Abstract 4346050: Innovative Use Of Rotational Atherectomy In Heavily Calcified Superior Mesenteric Artery Stenosis
Description of Case: An 82-year-old female with coronary artery disease (CAD) and obesity status post Roux-en-Y gastric bypass was hospitalized with months of postprandial abdomina...
Abstract 4343799: Genetically informed drug targeting of ryanodine receptor type 2 identifies new precision therapeutic candidates for catecholaminergic polymorphic ventricular tachycardia
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited disorder that is triggered by a catecholaminergic release, causing ventricular tachycar...
Abstract Sun1406: Early Onset of Harlequin Syndrome Following Prehospital Extracorporeal Cardiopulmonary Resucitation for Refractory Out-of-Hospital Cardiac Arrest
Case Presentation: A 37-year-old man with no known medical history presented to a pharmacy with agitation and severe chest pain radiating to the back. At 16:00, he experienced a wi...
Abstract 4362670: International Differences in Hemodynamic Response to Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension: A Multicenter Study from Japan and the Netherlands
Introduction: Prior studies showed notable hemodynamic differences in the response to balloon pulmonary angioplasty (BPA) for chronic thromboembolic pulmonary hypertension (CTEPH)...
Abstract 4370425: Soluble Urokinase Plasminogen Activator Receptor (suPAR), Lipoprotein(a), and Cardiovascular Outcomes in the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Chronic inflammation and elevated lipoprotein(a) [Lp(a)] are key contributors to residual cardiovascular risk. Soluble urokinase plasminogen activator receptor (suPAR),...
Abstract 4354017: Brown adipose tissue-derived GDF15 promotes survival following myocardial infarction independently of GFRAL
Introduction/Background: Brown adipose tissue (BAT) can exert beneficial cardiometabolic effects via the secretion of endocrine factors known as batokines. One such batokine is gro...
Abstract 4364120: Pharmacist Interventions Boosts Compliance and Cholesterol Medications Adherence
Introduction: Uncontrolled lipid levels significantly contribute to recurrent cardiovascular events and atherosclerotic cardiovascular disease (ASCVD) progression, resulting in inc...
Abstract 4358445: Elevated Lipoprotein(a) Is Independently Associated With Greater Infarct Size, Especially in Premature Atherosclerosis
Background: Elevated lipoprotein(a) (Lp[a]) is an independent, causal, genetic risk factor for CVD. While increasing infarct size corresponds with poor outcomes, it is unknown whet...
Abstract 4365952: Trends in Adoption of the Familial Hypercholesterolemia Diagnostic Code E78.01 in U.S. Healthcare Settings from 2016 to 2024
Background: The ICD-10 code for Familial Hypercholesterolemia (FH), E78.01, was introduced in 2016 to improve FH identification and care delivery. Real-world adoption of this code...
Abstract 4364481: Misinterpretation of Early Trials May Have Concealed Thrombolysis Advantage in Non-STE Myocardial Infarction: A systematic review and Meta-analysis
Background: The Fibrinolytic Therapy Trialists' (FTT) collaborative overview established thrombolysis for ST-elevation myocardial infarction (STEMI) but concluded it was harmful in...
Abstract 4340112: ECMO: Beating the Block on a Failing Heart
Case Report: A 26-year-old man with HTN and MDD presented via EMS with 1 day of myalgias, abdominal pain, and hypotension requiring fluid and epinephrine infusion en route after in...
Abstract 4371335: Optimizing Secondary Prevention with a Pharmacist-led Virtual Lipid Clinic
Background: Current AHA/ACC guidelines recommend high-intensity statin (HIS) therapy plus adjuvant therapies including ezetimibe and PCSK-9 inhibitors for the secondary prevention...
Abstract 4367683: From Door to Diagnosis: Prospective Evaluation of OpenAI o3 for Real-Time STEMI/NSTEMI and Culprit Artery Prediction in Acute Myocardial Infarction
Background: Emergency physicians must interpret ECGs, await high-sensitivity troponins, and achieve timely door-to-balloon interventions in acute myocardial infarction(AMI). Staff...
Abstract 4370589: Exercise Induced Improvement in Cognition is Associated with Improved Pulse Wave Velocity in Older Adults with Kidney Disease
Introduction: Older patients with chronic kidney disease (CKD) are at high risk of cognitive impairment. We have previously demonstrated that a 6-month home-based exercise training...
Abstract 4338147: Early Versus Late Direct Oral Anticoagulant Initiation After Acute Ischemic Stroke With Atrial Fibrillation: A Bayesian Meta-Analysis of Randomized Controlled Trials
Introduction: The optimal timing to initiate direct oral anticoagulants (DOACs) after acute ischemic stroke in patients with atrial fibrillation (AF) remains uncertain....
Abstract 4366742: Factors influencing self-care in elderly patients with concurrent diabetes and coronary artery disease, and their spousal contribution: An Actor-Partner Interdependence Model analysis
Background: Self-care in elderly patients with coronary artery disease (CAD) and diabetes is critical for disease management. Spousal support plays a pivotal role in self-care beha...
Abstract 4359043: NVC-001 – An AAV Gene Therapy Functional Cure for LMNA Dilated Cardiomyopathy
Background: LMNA-related Dilated Cardiomyopathy (LMNA-related DCM) is an aggressive type of DCM caused by pathogenic mutations in the LMNA gene that comprises 5-6% of genetic DCM c...
Abstract 4367705: A Rare Case of Watchman Device Embolization to the LVOT Managed by Percutaneous Retrieval
Case: An 82-year-old male with a history of paroxysmal atrial fibrillation, coronary artery disease, heart failure with preserved ejection fraction, and end-stage renal disease on...