Circulation
Articles in this Issue
Abstract Sun1408: A Rare Case of Adalimumab-Induced Cardiac Tamponade in a Patient with Psoriatic Arthritis
Case Presentation: A 58-year-old man with Down Syndrome, Alzheimer’s dementia, and psoriatic arthritis (on adalimumab) was admitted for chest pain and dyspnea due to a loculated ri...
Abstract 4367542: Impact of Mineralocorticoid Receptor Antagonists on Atrial Fibrillation Catheter Ablation Outcomes in Patients with HFpEF.
Background: The effects of Mineralocorticoid receptor antagonist (MRAs) on atrial fibrillation (AFib) outcomes following catheter ablation in patients with heart failure with prese...
Abstract 4363164: Role of Cellular Communication Network Protein Family in Pulmonary Arterial Hypertension
Background: The Cellular Communication Network (CCN) protein family has been implicated in various lung diseases and in states of pulmonary vascular remodeling. CCN2 has been shown...
Abstract 4370898: Long-Term Impact of GLP-1 Receptor Agonists on Cardiovascular Outcomes in Patients Treated with Hematopoietic Stem Cell Transplantation: A Propensity-Score Matched Analysis
Background: Effective risk factor modification, including management of obesity and diabetes mellitus (DM), is essential to mitigating cardiovascular complications after hematopoie...
Abstract 4372111: Sex-stratified trends and segmental breakpoints in age-standardized death rates for ischemic heart disease: a multi-country analysis
Background: Ischemic heart disease (IHD) is one of the most significant health challenges in the world, affecting millions of lives each year....
Abstract 4346410: Association of Left Atrium Reservoir Strain by Cardiovascular Magnetic Resonance with New Onset Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
Introduction: Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM) and associated with significant morbidity and mortality. Ear...
Abstract 4365974: The MSX1-E135D Mutation Disrupts SUMOylation, Interactions with T-box Proteins, and Smooth Muscle Actin Expression
Introduction: We previously reported a putative mutation in Muscle Segment Homeobox 1 (MSX1; p.E135D) in a multigenerational family with arrhythmogenic cardiomyopathy, myocardial f...
Abstract 4359918: Hemodynamic Effects of Guideline-Based Sedation in Mechanically Ventilated Adults: A Multi-center Observational Analysis
Background: Propofol is a first-line sedative for critically ill adults receiving invasive mechanical ventilation (IMV). However, it can contribute to hemodynamic instability, espe...
Abstract 4362312: The Effect of Bedtime vs. Morning Antihypertensive Treatment on Cardiovascular Events: Meta-Analysis
Background: Antihypertensive medications are essential for preventing cardiovascular events and have traditionally been administered in the morning. Recent studies have suggested t...
Abstract 4359697: Changes in Management of Acute Aortic Syndrome with Vascular Medicine Involvement in a Multidisciplinary Aortic Team
Background: Recent AHA and ESC guidelines endorse multidisciplinary management of acute aortic syndromes (AAS), but the impact of including non-surgical cardiovascular specialists...
Abstract 4365023: The Wrong Hoofbeats: Chagas Cardiomyopathy Presenting as Ventricular Tachycardia with Misleading Lyme Serology
Background: Chagas cardiomyopathy is a common cause of nonischemic cardiomyopathy in Latin America and often presents with ventricular arrhythmias. With increasing global migration...
Abstract 4367793: Efficacy and Safety of Oral Anticoagulant Monotherapy vs. Dual Therapy in Atrial Fibrillation with Stable Coronary Artery Disease: A Systematic Review and Meta-Analysis
Introduction: In patients with atrial fibrillation (AF) and stable ischemic heart disease, guidelines currently recommend oral anticoagulant (OAC) monotherapy over combination ther...
Abstract 4359925: Brain-Derived Exosomal Biomarkers of Neuroinflammation and Brain Iron Deficiency in Infants with Critical Congenital Heart Disease: A Pilot Study
Background: Up to 50% of infants with critical congenital heart disease (CCHD) experience neurodevelopmental delay, potentially due in part to neuroinflammation and iron deficiency...
Abstract 4366730: Consumer Wearables Heart Rate Metrics and Ventricular Arrythmia Risk in Heart Failure: An All of Us Cohort Analysis
Background: Consumer activity trackers generate continuous heart rate (HR) and step counts that could complement clinical predictors of ventricular tachycardia/ventricular fibrilla...
Abstract 4362628: Integrating Polygenic and Clinical Risk Factors Enhances Stability of Coronary Artery Disease Risk Prediction
Introduction: The interest in using Polygenic Risk Scores (PRSs) for CAD risk assessment is growing, but variability in individual risk estimates between different PRS models is a...
Abstract 4361325: Pregnancy Outcomes in Heart Transplant Recipients: A Systematic Review and Meta-Analysis of Maternal and Neonatal Morbidities.
Background: Advances in heart transplant (HTx) have increased the number of reproductive-aged women with grafts considering pregnancy. However, this remains a high-risk scenario du...
Abstract 4340696: The Prevalence of Pulmonary Hypertension in Hypertensive Heart Failure in Sub-Saharan Africa
Background: Elevated blood pressure (BP) presents a major challenge in sub-Saharan (SSA), affecting ~1 in 10 people. The left ventricle (LV) adapts to chronic pressure overload wit...
Abstract Sat704: A Hospital-Wide Multidimensional Approach to Pediatric In-Hospital Cardiac Arrest Review: Early Identification and Prevention
Introduction/Background: Pediatric In-Hospital Cardiac Arrest (P-IHCA) remains a critical patient safety and quality improvement issue. Conventional reviews often fail to capture e...
Abstract 4365798: Gaps In Risk Factor Management Prior To Major Adverse Events As First Presentation Of Atherosclerotic Cardiovascular Disease
Background: Atherosclerotic cardiovascular disease (ASCVD) most often manifests initially with a myocardial infarction or stroke. While the aetiology of atherosclerosis and benefit...
Abstract 4367238: Transcatheter Mitral Edge-to-Edge Repair versus Surgical Mitral Valve Repair in Elderly Patients with Heart Failure: A Propensity Matched Analysis
Background: Transcatheter mitral valve edge-to-edge repair (M-TEER; MitraClip) has emerged as a less invasive alternative to surgical mitral valve repair (SMVr) in older adults wit...
Abstract 4368949: The Glucose–RBPJ–Mitochondrial Axis: A Metabolic Trigger of Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is a fatal vascular disease marked by mitochondrial dysfunction (MD), vascular proliferation, and right ventricular failure. While...
Abstract 4366091: Comparative Effectiveness of Percutaneous Mitral Valve Repair, Surgery, and Medical Therapy in Patients with Mitral Regurgitation: A Network Meta-Analysis
Introduction: Functional mitral regurgitation (MR) is caused by annular dilation or left ventricular remodeling rather than primary valve disease. If untreated, it is linked to adv...
Abstract 4338345: Cardiac MRI-derived Ventricular Volumes in Single Ventricular Congenital Heart Defects: A Systematic Review and Meta-Analysis
Background: Cardiac magnetic resonance (CMR) is the reference standard for volumetric analysis of functional single-ventricle (FSV) congenital heart defects (CHD), with the advanta...
Abstract 4366207: When Cancer Isn’t Cancer: Unmasking a Rare Cardiac Mass Impersonator
Background: Transthoracic echocardiography (TTE) is a cornerstone for identifying intracardiac pathology due to its accessibility and rapid utility. However, its limited specificit...
Abstract Sat407: Associations Between Comorbidities and Clinical Characteristics with Mortality and Motor Outcomes After Cardiac Arrest
Introduction: Hypoxic-ischemic brain injury after cardiac arrest (CA) results from both the primary insult of cerebral hypoperfusion and secondary injury mechanisms post–return of...