Circulation
Articles in this Issue
Abstract 4363947: Ferroptosis induction in myocardial ischemia reperfusion injury is time of day dependent
Introduction: Ferroptosis, an iron mediated regulated form of cell death has been implicated in myocardial ischemia-reperfusion (IR) injury among other cardiac conditions. Cellular...
Abstract 4364923: Does Glycemic Control Matter for Atrial Function? A Propensity-Matched Study Using Echocardiographic Strain Analysis
Introduction: Diabetes mellitus (DM) and atrial myopathy play a key role in the pathophysiology of heart failure with preserved ejection fraction. However, data on the impact of DM...
Abstract 4336121: Clinical and Echocardiographic Determinants of Prognosis in Tuberculous Pericarditis
Background: Tuberculous pericarditis (TBP) remains a significant cause of morbidity and mortality, particularly in regions where tuberculosis is endemic. While clinical presentatio...
Abstract 4344186: Distinct Clinical Differences Between Right Aortic Arch with Aberrant Left Subclavian Artery and Double Aortic Arch
Background: Vascular ring (VR) is a rare congenital aortic arch anomality causing external compression on trachea and/or esophagus with variable onset and severity. Two common type...
Abstract 4370350: Characteristics, Management and Long-term Outcomes of Coronary Perforation Secondary to Percutaneous Coronary Intervention (PCI):Experience from Pakistan
Background: Percutaneous Coronary Intervention (PCI) is essential for coronary artery disease management. Coronary Artery Perforation (CAP), though rare (0.4% incidence), is a crit...
Abstract 4360723: Routine Atherosclerotic Cardiovascular Disease Screening in Underserved Primary Care Settings: A Quality and Improvement Study.
Introduction: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in the United States and worldwide, and 80% of the disease is preventable. Unlike some ma...
Abstract 4363027: Paradoxical Renal Protection after Euglycemic DKA in a CKD Stage 4 Diabetic Patient on Empagliflozin: A Case Report and Mechanistic Insights
Introduction: Over the last few years, studies have demonstrated that the usage of SGLT2 inhibitors in patients with diabetes mellitus and chronic kidney disease has significantly...
Abstract 4368219: Comparative Efficacy and Safety of Vutrisiran, Acoramidis, Tafamidis in Transthyretin Amyloid Cardiomyopathy: A Network Meta-Analysis
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, life-threatening disorder caused by transthyretin deposition in cardiac tissue. Tafamidis, Acoramidis,...
Abstract 4366904: Drug-coated balloons versus drug-eluting stents in patients with Large coronary artery disease: an updated meta-analysis
Background and Aim: Coronary artery disease (CAD) accounted for 2.2% of the global disease burden and 32.7% of cardiovascular disorders. Drug-coated balloon (DCB) is a known treatm...
Abstract 4370654: Regulation of SCN5A Alternative Splicing by LINC00667 in Human Cardiomyocytes
Background: Alternative splicing of SCN5A mRNA reduces Nav1.5 channel density in cardiomyopathy, impairing myocardial excitability. The long noncoding RNA LINC00667 has been linked...
Abstract 4367175: Effects of Device-Measured Physical Activity on Disease Progression and Cardiovascular Outcomes in Phenotype-Negative Carriers of Cardiomyopathy-Associated Rare Variants
Background: Exercise may lead to disease progression and higher risk of sudden death in certain cardiomyopathies conferred by rare genetic variants. Whether general activity recomm...
Abstract 4369026: Proteasomal Degradation of MyD88 Directs TGFβ Induced Fibroblast Transformation in Heart Failure
Background: Cardiac fibrosis is a pathological hallmark of heart failure (HF) leading to cardiac dysfunction. Cardiac fibroblasts (CFB) are central mediators of both cardiac fibros...
Abstract 4367108: Impact of PCSK9 Inhibitors on Mortality and Cardiovascular Events in Statin-Treated ASCVD Patients with Elevated Lipoprotein A: A Retrospective Study
Background: Lipoprotein(a) [Lp(a)] is an independent and genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD). In patients with well-controlled low...
Abstract 4373223: Takotsubo Cardiomyopathy Among Adults Undergoing Chemotherapy: Evaluating Predictors and Impact on Mortality
Introduction: Takotsubo cardiomyopathy (TC) is a rare but clinically significant complication observed in patients undergoing chemotherapy. The relationship between TC and chemothe...
Abstract 4367560: Preliminary Results from the LiLAC Study: Living Life After Cardiogenic Shock Assessing Long-Term Quality of Life Outcomes Using Novel Digital Remote Monitoring Tools
Introduction: Studies on health-related quality of life (QoL) after discharge from cardiogenic shock (CS) are scarce. Patient-reported outcomes are essential to understanding long-...
Abstract 4372096: Reappraising left ventricular wall thickness in transthyretin cardiac amyloidosis: A survey of the diagnostic journeys of patients with normal posterior wall thickness
Background: Transthyretin cardiac amyloidosis (ATTR-CM) is becoming a more prominent and recognized etiology for diastolic heart failure. The debut of disease-modifying therapies h...
Abstract 4345280: The Angiogenic Potential of Dipeptidyl Peptidase 4 Inhibition in a Large Animal Model of Coronary Artery Disease in the Setting of Metabolic Syndrome
Introduction: Metabolic syndrome has been shown to double the risk of cardiovascular-related mortality. As cardiometabolic disease advances, so too does the pathological changes in...
Abstract 4372568: Medical Management Triumph: Spontaneous Resolution of a Large Native Valve Vegetation in a Case of Pediatric Infective Endocarditis
Introduction: Native valve endocarditis (NVE) is rare in children, particularly in structurally normal hearts. Vegetations >10 mm pose a high embolic risk and often prompt surgi...
Abstract Sun106: Effects of different positive pressure ventilation delivery methods on intraventricular, central and peripheral hemodynamics during automated head-up CPR
Background: The efficacy of different conventional ventilation during automated head-up (AHUP) CPR using active decompression and impedance threshold device with head and torso ele...
Abstract 4366340: Use of 3D Virtual Modeling to Guide Mitral Valve Partial Heart Transplantation in a Pediatric Patient with a Mechanical Mitral Valve
Background: Mitral valve (MV) partial heart transplantation (PHT) is an exceptionally rare and technically demanding procedure, with only one prior case reported using a living don...
Abstract 4372125: Elevated Peri-coronary Adipose Tissue attenuation association with Coronary Plaque Progression in Type 2 Diabetes Mellitus Patients
Introduction: Peri-coronary adipose tissue (PCAT) attenuation, quantified by Coronary Computed Tomography Angiography (CCTA), is a validated non-invasive marker for assessing coron...
Abstract 4366069: Neighborhood Socioeconomic Deprivation Relates to Epigenetic Modification of the <i>LPA</i> gene and Potential Increase in Circulating Plasma Lp(a) Levels in African Americans: A Pilot Study
Background: Lp(a) has gained increased attention as a significant risk factor for cardiovascular disease (CVD), and its plasma levels are up to 3-fold higher in African Americans (...
Abstract 4366953: When the Pleural Effusion Speaks- Uncovering Cardiac Intimal Sarcoma through Persistent Pleural Effusion
Introduction: Primary malignant cardiac tumors are extremely rare, with an incidence rate of less than 0.005%, and among these, intimal sarcoma is a poorly differentiated, highly a...
Abstract 4365105: Outcomes of Left Atrial Appendage Occlusion Versus Direct Oral Anticoagulants in Active Cancer Patients with Atrial Fibrillation
Background: Atrial fibrillation (AF) and cancer frequently co-exist, presenting a challenge due to coagulopathy, procedural needs, and elevated bleeding risk. Left atrial appendage...
Abstract 4366422: Peripheral Oxygen Extraction Is Impaired in Adults with Fontan Circulation
Background: Fontan circulation is characterized by the absence of a subpulmonary ventricle with resultant systemic venous hypertension. Despite exercise intolerance being nearly un...