Circulation
Articles in this Issue
Abstract Sat506: The efficacy of New Protocol for Out-of-hospital Cardiac Arrest Patients with “do not attempt resuscitation” orders in Japan
Background: In Japan, emergency medical technicians (EMTs) are not permitted to terminate resuscitation for patients with out-of-hospital cardiac arrest (OHCA), even if the patient...
Abstract 4370975: Associations between social determinants and cardiovascular disease risk factors among Black Americans, Afro-Caribbeans, African immigrants and White adults: findings from the 2013-2018 National Health Interview Survey
Background: Social determinants of health (SDOH) impact the burden of cardiovascular disease (CVD) among Black adults, but limited information is available on how various SDOH dime...
Abstract 4365415: Comparative Efficacy of Glucagon-Like Peptide-1 Receptor Agonists and Co-Agonists for Weight Loss Among Patients Without Diabetes: A Network Meta-Analysis
Background: Multiple glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and newer dual/triple co-agonists promote weight loss in adults without diabetes, yet comparative efficac...
Abstract 4364716: Artificial Intelligence Analysis of Free-Text Discharge Summaries Facilitates Automated Risk Stratification for Cardiac Surgery Readmissions
Background: Cardiac surgery patients at high risk of readmission can be identified using risk calculators that rely on structured features requiring time-consuming manual chart rev...
Abstract 4359605: Associations Between Patient-Physician Race and Language Concordance and Direct Oral Anticoagulant Initiation in Patients with Non-Valvular Atrial Fibrillation
Background: For patients with non-valvular atrial fibrillation (NVAF) and a high risk of stroke who require anticoagulation treatment, guidelines recommend direct oral anticoagulan...
Abstract 4370709: Individualized mHealth Intervention and 12-Month Health Behavior Trajectories for Coronary Artery Disease: An Open-label, Multicenter Randomized Controlled Trial
Background: Coronary heart disease (CHD), the global leading cause of death (8.9 million annual fatalities), requires combined lifestyle and medication management. We developed iCA...
Abstract 4356577: Racial and Socioeconomic Disparities in Inpatient Use of PCSK9 Inhibitors for ASCVD: A Retrospective Cross-Sectional Analysis of the National Inpatient Sample
Background: PCSK9 inhibitors significantly reduce LDL-C levels and cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD), particularly following acu...
Abstract 4370245: Smarter Together: How Artificial Intelligence Algorithms are Enhancing Clinicians in Early Detection of CHD Congenital Heart Disease?
Background: Congenital heart disease (CHD) is the most common congenital anomaly, affecting 8–10 per 1,000 live births globally, and is a leading cause of perinatal morbidity and m...
Abstract 4365705: Cardiology Medications and Medicare Spending: Opportunities for Savings Using Mark Cuban Cost Plus Drug Company and Costco Member Prescription Program Pricing
Introduction: Medicare Part D represents a significant portion of government drug spending, underscoring the importance of efforts to pursue potential cost savings through alternat...
Abstract 4371540: Barriers to Research Participation: The Impact of Race, Education, and Socioeconomic Status in a Diverse Urban Population
Background: Despite national efforts to diversify clinical trial populations, participation remains disproportionately low among racial and ethnic minorities. This underrepresentat...
Abstract 4366728: Proteomics analysis identifies sub-phenotypes amongst clinically similar patients with Idiopathic Pulmonary Arterial Hypertension
Background: Patients with idiopathic pulmonary arterial hypertension (IPAH), a progressive pulmonary vasculopathy, may be clinically similar, yet have different responses to therap...
Abstract 4362826: Use of Stress Cardiac Magnetic Resonance to Evaluate Prognosis in Patients with Cardiac Implantable Electronic Devices
Background: The prevalence of cardiac implantable electronic devices (CIED) is increasing, with over 300,000 new implants annually in the U.S. Stress cardiac magnetic resonance (CM...
Abstract 4358777: Adverse Events Associated with Early vs. Late SGLT2i Initiation After Heart Failure Hospitalization: A Target Trial Emulation Study
Introduction: Although sodium-glucose cotransporter 2 inhibitors (SGLT2i) are guideline-directed medical therapy for heart failure, their safety in patients with acute decompensate...
Abstract 4368024: Cardiopulmonary Bypass and Aortic Cross-Clamp Times as Predictors of Outcomes in ECMO-Supported Cardiotomy Patients
Introduction: Cardiopulmonary bypass time (CPBT) and aortic cross-clamp time (AXCT) are independently associated with postoperative morbidity and mortality. However, no universally...
Abstract 4373374: Impact of Chronic Venous Insufficiency on Morbidity and Mortality Among Patients Hospitalized for Heart Failure: A Propensity-Matched Real-World Cohort Study
Background: Chronic venous insufficiency (CVI), characterized by venous valve incompetence and vein wall dysfunction leading to venous stasis and hypertension, affects up to 40% of...
Abstract Sat1101: Serum Lactate/Albumin Ratio at Hospital Arrival and 30-day Neurological Outcome in Patients Receiving Targeted Temperature Management after Out-of-hospital Cardiac Arrest
Background: The patients most likely to benefit from targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) are unknown. We investigated whether a lower...
Abstract 4369459: Depressive symptoms have a differential expression in two models of heart failure
Introduction: Patients with HFpEF present a higher prevalence of major depressive disorder MDD (13%) than patients with HFrEF (6%). Several studies report that HFpEF and depression...
Abstract 4364215: Impact of REGN5381, a Monoclonal Antibody Agonist to Natriuretic Peptide Receptor 1, on Pulmonary Capillary Wedge Pressure in Patients With Heart Failure With Preserved Ejection Fraction
Introduction: Activation of natriuretic peptide receptor 1 (NPR1) regulates vascular tone, lowers venous pressures, and effects natriuresis and diuresis, which may have therapeutic...
Abstract 4357315: AZD0233: a CX3CR1 Modulator that Regulates Immune Cells, Improves Cardiac Function, and Alleviates Myocardial Fibrosis in a Mouse Model of Dilated Cardiomyopathy
Background: AZD0233 is an orally administered, selective allosteric modulator of the C-X3-C motif chemokine receptor 1 (CX3CR1). CX3CR1 is a transmembrane receptor expressed by sub...
Abstract 4347985: Hypertrophic Cardiomyopathy and Exercise: A Meta-Analysis, and Trial Sequential Analysis of Randomized Controlled Trials
Background: Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death (SCD) among young individuals and athletes. Guidelines support individualised exercise pr...
Abstract 4370863: Superoxide Regulates Sex-Dependent Upper Body Irradiation-Induced Cardiopulmonary Injury
Introduction: Upper body irradiation (UBI) is a clinically relevant modality for thoracic cancer treatment. Ionizing radiation (IR)-induced pathophysiological effects are directly...
Abstract 4344420: Validation of the Padua Prediction Score in Predicting Venous Thromboembolism Among Patients with Chronic Kidney Disease Admitted to the Intensive Care Unit: A Retrospective Cohort Study
Introduction/Background: Chronic kidney disease (CKD) is associated with a prothrombotic state, increasing the risk of venous thromboembolism (VTE) among critically ill patients. D...
Abstract 4369880: Beyond the Cuff: Diagnosing Baroreceptor Failure After Head and Neck Radiation
Labile blood pressure in elderly patients is often multifactorial but may rarely stem from autonomic dysregulation due to structural baroreceptor damage. One under-recognized etiology is radiation-ind...
Abstract 4366018: Lung Injury Following Stent Implantation in Adult Patients with Pulmonary Artery Stenosis
Backgrounds: Pulmonary artery stenosis in adults presents a therapeutic challenge Although percutaneous transluminal pulmonary angioplasty has emerged as an effective treatment, lu...
Abstract 4344801: Metabolic Health, Arterial Stiffness, and Incident Cardiovascular Diseases: The Framingham Heart Study
BACKGROUND: It has been established that metabolic syndrome (MetS), its subclinical counterpart (insulin resistance, IR), and arterial stiffness (AS) are prominent markers of cardi...