Circulation
Articles in this Issue
Abstract 4359581: An Accessible Image-based Artificial Intelligence-Electrocardiogram Risk Score Enhances Atherosclerotic Cardiovascular Disease Risk Prediction Beyond Traditional Risk Scores
Background: Estimating atherosclerotic cardiovascular disease (ASCVD) risk is crucial in guiding clinical decisions about primary prevention strategies. Well-validated clinical ris...
Abstract Sat1405: Racial Disparities in Cardiovascular Outcomes Following Cardiac Arrest: A Real-World Analysis Using the TriNetX Database
Background: Cardiac arrest is a critical medical emergency with high mortality rates. Despite advancements in medicine, racial disparities in outcomes continue to be a significant...
Abstract 4366963: Practice Variation in Clinician Guidance Regarding Sport Participation in Congenital Heart Disease
Introduction: Athletic participation is increasing among individuals with congenital heart disease (CHD), but there are limited data to guide sports participation decision-making i...
Abstract 4351564: Primary Results of the VICTORION-NOVEL (LDL-C maNagement PrOgram in Atherosclerotic Cardiovascular Disease (ASCVD) patients with Elevated LDL-C) Lipid Optimization Multicenter Implementation Trial
Background: Most patients with atherosclerotic cardiovascular disease (ASCVD) do not advance beyond statin therapy and do not achieve the recommended low-density-lipoprotein choles...
Abstract 4366240: Transient pharmacological reprogramming reverses endothelial senescence and promotes vascular regeneration
Endothelial cell (EC) senescence has been identified as a significant contributor to the development of cardiovascular disease, resulting in impaired angiogenesis and tissue regeneration. Consequently...
Abstract 4370404: Glucagon-Like Peptide-1 Receptor Agonists and Anthracycline Therapy in Breast Cancer: A Real-World Propensity-Matched Analysis
Background: Anthracycline cardiotoxicity increases breast cancer morbidity and mortality. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve cardio-renal outcomes in diab...
Abstract 4364568: Classifying Chest Pain as Typical vs. Atypical Fails to Discriminate Acute Coronary Occlusion and Does Not Predict Mortality
Background: Current US guidelines discourage classifying chest pain as ‘typical’ or ‘atypical,’ yet this dichotomous approach remains widespread in clinical practice. We aimed to d...
Abstract 4360664: A Case of Recurrent Acute Coronary Syndrome and Cardiogenic Shock due to Apolipoprotein A-IV Amyloidosis
Background: Amyloidosis occurs when endogenous circulating proteins misfold and are deposited in various tissues, including the myocardium. Apolipoprotein A-IV (Apo-AIV) amyloidosi...
Abstract 4373476: Disparities in Major Adverse Cardiovascular Outcomes Based on Body Mass Index and Estimated Glomerular Filtration Rate in Glucagon-like Peptide-1 Receptor Agonists Users Among Patients With and Without Diabetes Mellitus: A Meta-analysis of 9 Randomized Controlled trials.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM) and high cardio...
Abstract 4371524: The Right Ventricle as a Hidden Culprit: How Sympathetic Overdrive Fuels Pulmonary Congestion in Heart Failure with Preserved Ejection Fraction
Background: In the era of heart failure (HF) pandemics, prevention of acute HF is an urgent issue to be overcome. However, the mechanisms underlying the development of acute HF are...
Abstract 4360009: Green Space Visitation and Coronary Heart Disease Across Diverse Climates: A Geospatial Analysis in Three U.S. Cities
Background: Access to and use of green spaces are increasingly recognized as vital for cardiovascular health, yet few studies have quantified green space exposure behaviorally or e...
Abstract 4367166: A Multicenter Study of Detection of Pulmonary Hypertension Based on Point-of-Care 12- Lead ECG Data
Background: Pulmonary hypertension (PH) is a life-threatening disease affecting up to 1% of the global population. Diagnosis can be challenging and is often delayed due to the need...
Abstract 4346009: Case volumes and Outcomes of Early Career Interventional Cardiologist performing TAVR in the United States
Background: There is a well-established relationship between volume and outcomes among TAVR operators. However, there is little data about the association of years of experience of...
Abstract 4363206: Electronegative L5 Low-Density Lipoprotein Rapidly Impairs Endothelial Proliferation and Triggers Early Senescence
Background: Electronegative low-density lipoprotein (LDL) subfractions, particularly L5, the most electronegative, have been implicated in endothelial cytotoxicity and atherogenesi...
Abstract 4346346: Biomarkers in Patients with Newly Diagnosed Dilated Cardiomyopathy: A Study from the Pediatric Cardiomyopathy Registry
Background: Children with dilated cardiomyopathy (DCM) are at high risk for morbidity and death. There are few data on the utility of biomarkers in this population....
Abstract 4347761: S100A9 Induces BRD4 (K292) Lactylation in Macrophages to Exacerbate Inflammaging in Diabetic Cardiomyopathy
Introduction: In age-related metabolic diseases such as diabetes, inflammaging exerts systemic pro-inflammatory responses and may disrupt interorgan communication and crosstalk. Pr...
Abstract 4358833: Corheart 6 Ultracompact Magnetically Levitated Left Ventricular Assist Device in a Patient with Obese Heart Failure
Due to the critical shortage of cardiac transplant donors, durable left ventricular assist device (LVAD) has become an effective alternative therapy for end-stage heart failure (ESHF). Miniaturization...
Abstract Sun707: History of Two-minute vs. One-minute Cardiopulmonary Resuscitation: Trade-offs between Chest Compression Fraction and Ventricular Fibrillation Duration
Background: The two-minute interval between rhythm analyses has long been the standard in resuscitation, primarily due to its simplicity and ease of application. However, there is...
Abstract 4365895: Self-Reported Loneliness Independently Predicts Cardiovascular Mortality in a Diverse National Cohort
Background: Loneliness is a growing public health concern. In 2022, the AHA identified it as a contributor to poor cardiovascular health, followed by a 2023 U.S. Surgeon General ad...
Abstract 4368388: Hydrogel-Delivered Cardiac Atrial Appendage Stem Cells as a Strategy to Preserve Cardiac Function Following Myocardial Infarction
Background: Myocardial infarction (MI) leads to extensive loss of cardiomyocytes and adverse remodeling, often progressing to heart failure. While stem cell-based approaches are co...
Abstract 4368518: Impact of Cerebral Embolic Protection Devices on Stroke Outcomes in TAVR: A Systematic Review and Meta-Analysis of Randomized and Real-World Studies
Background: Stroke is a devastating complication of transcatheter aortic valve replacement (TAVR). Cerebral embolic protection devices (CEPD) have been introduced to reduce TAVR-re...
Abstract 4341144: Prospective Use of Hemolysis Index as a Surrogate for Clinical Hemolysis in Patients Receiving Temporary Mechanical Circulatory Support: Pilot Study
Introduction: Rates of temporary mechanical circulatory support (tMCS) have increased by more than 300% since FDA approval in the 1990s. With increased utilization, it is imperativ...
Abstract Sat804: Improving Bystander CPR Knowledge and Preparedness Among Secondary School Students and Healthcare Workers in Ikare-Akoko, Nigeria.
Background: Out-of-hospital cardiac arrest (OHCA) is a major cause of death globally, with especially high mortality in low-resource settings due to limited emergency preparedness....
Abstract 4367277: Intracardiac Echocardiography Use and Outcomes Following Catheter Ablation of Ventricular Tachycardia: A Meta-Analysis
Introduction: Intracardiac echocardiography (ICE) has emerged as a potentially valuable tool during ventricular tachycardia (VT), offering real-time visualization of cardiac anatom...
Abstract 4364638: Aberrant Splicing of Mitochondrial Dynamics Genes Impairs Cardiac Bioenergetics in Myotonic Dystrophy type I (DM1)
Background: DM1 is a (CTG)n trinucleotide repeat expansion disease in the 3’UTR of the DMPK gene. Once expressed, the repeat RNAs form toxic hairpins that sequester the muscle blin...