Circulation
Articles in this Issue
Abstract 4371363: Evaluating the Joint Association of Prehypertension and Albuminuria with CardiovascularOutcomes.
Background: Elevated blood pressure and albuminuria are well-established independent risk factors for cardiovascular disease (CVD). Studies have evaluated the relationship between...
Abstract 4365814: Impact of Lipoprotein(a) on Aortic Valve Replacement in Chinese Patients with Mild-to-Moderate Calcific Aortic Valve Stenosis
Background: Lipoprotein(a) [Lp(a)] is an independent risk factor for calcific aortic valve stenosis (CAVS), but its association with aortic valve replacement (AVR) risk in the Chin...
Abstract 4368246: Platelet Transcriptomic for Coronary Artery Disease Diagnosis Using Machine Learning
Background: Non-invasive assessment of coronary artery disease (CAD) in patients with suspected angina is essential for guiding clinical management strategies. However, current non...
Abstract 4369215: Generalizability of AI-based Cardiomyopathy Risk Prediction among Childhood Cancer Survivors
Background: Children whose cancer is treated with anthracycline chemotherapy and/or chest directed radiation (RT) are at risk for premature cardiovascular disease including cardiom...
Abstract 4361033: Cardiac RBFOX1 Deficiency Enhances Glucose and Ketone Metabolism and Provides Tolerance Against Ischemia Reperfusion Injury
Introduction: Hibernation or aestivation involve physiologic and molecular adaptations across species that enhance survival under extreme conditions. These include reduced respirat...
Abstract 4357554: Association between metformin exposure and outcomes in diabetic patients undergoing cardiac surgery: A retrospective cohort study
Background: This study aimed to evaluate the association between metformin exposure and in-hospital outcomes in critically ill patients with type 2 diabetes mellitus (T2DM) who und...
Abstract 4368940: Contemporary Demographics, Management, and Outcomes in Acute Pulmonary Embolism: A Pre- and Post-AI Era Comparison
The paradigm for the treatment of acute pulmonary embolism (PE) has been changing with the introduction of new interventional devices and techniques. Concurrently, computer-aided smart applications fo...
Abstract 4370367: Artificial Intelligence to Automate Guideline-Based Evaluation of Left Ventricular Diastolic Function
Background: Left ventricular diastolic dysfunction (LVDD) is integral to diagnostics and risk stratification for both cardiac and extracardiac pathologies, such as heart failure an...
Abstract 4366086: Identification of TRIM47 as a molecular switch for protective immunity against Influenza A virus-induced viral myocarditis
Introduction: Myocarditis, defined as an inflammatory injury to the myocardium, is irreversible with a 20% fatality rate in 2 years and a 50% fatality rate in 5 years. The most com...
Abstract 4344459: Machine Learning–Derived Patient Subgroups in Inpatient Cardiac Arrest: A National Inpatient Sample Analysis
Background: In-hospital cardiac arrest (IHCA) affects over 60,000 patients annually in the U.S., yet presentations and outcomes are highly heterogeneous. Unsupervised phenotyping u...
Abstract 4353928: Long-Term Cardiovascular Risks Based on Stratification by Severity of Hypertension Disorders of Pregnancy Disease
Background: It is well established that hypertensive disorders of pregnancy (HDP) confer downstream risk of cardiovascular (CV) disease. The purpose of this study was to assess lon...
Abstract 4367364: A Multicenter Friedreich Ataxia Registry Identifies Posterior Wall Thickness as a Predictor of Major Adverse Cardiac Events
Background: Cardiac disease is the leading cause of premature mortality in Friedreich Ataxia (FA). However, validated prognostic indicators or early imaging biomarkers that can rel...
Abstract 4364875: Perceived Stress and Coronary Endothelial Dysfunction in Postpartum Women with a History of Preeclampsia
Introduction: Impaired nitric oxide-mediated coronary endothelial function (CEF) is a predictor of future cardiovascular (CV) events and may be impaired in women with preeclampsia...
Abstract 4371056: Sedation Strategies in Cardiogenic Shock: Is Propofol Safer Than We Think?
Introduction: Propofol has shown favorable outcomes in mechanically ventilated ICU patients, including shorter ventilation times, faster arousal, and reduced ICU stays. Despite the...
Abstract 4366398: Healthcare Inequities Predictive of Morbidity and Mortality in Congenital Heart Surgery
Introduction: Despite medical advances in congenital heart surgery, disparities in outcomes remain. Social determinants of health (SDoH) are known contributors to healthcare inequi...
Abstract 4369813: Lower Caregiving Competency Increases Associations Between Biomarkers of Cardiovascular Risk
Introduction: The COOL-HF (caregiver (CG) opportunities for optimizing lifestyles) randomized clinical trial tested a psychoeducational intervention (with and without exercise) for...
Abstract 4369037: β-alanine Supplementation Improves Diastolic Function in Heart Failure with preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFpEF) represents a major unmet need in cardiovascular medicine, yet understanding of its causative mechanisms is limite...
Abstract 4361456: Impact of Procedural Sequence on Outcomes in Combined Atrial Fibrillation Ablation and Left Atrial Appendage Occlusion: A Meta-Analysis of Occlusion-First vs. Ablation-First Strategies
Background: In single-session atrial fibrillation (AF) procedures combining catheter ablation (CA) and left atrial appendage closure (LAAC), optimal sequencing, ablation-first (AF)...
Abstract 4365694: Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Mortality and Cardiovascular Outcomes Following TAVR in Heart Failure Patients: A Propensity-Matched Cohort Study
Introduction/Background: SGLT2 inhibitors (SGLT2i) have demonstrated cardiovascular and renal benefits in patients with heart failure (HF), yet their effect in individuals undergoi...
Abstract 4369272: The enhanced potential of electrocardiogram interpretation empowered by a vision–language foundation model
Background: Electrocardiography (ECG) is a cornerstone of cardiovascular disease (CVD) diagnosis, but it faces limitations in spatial resolution and susceptibility to artifacts. Re...
Abstract 4354717: Specific Microbial Metabolite Enhances the Anti-Atherosclerotic Efficacy of Colchicine by Improving Bioavailability
Background: Long-term, low-dose oral administration of colchicine has demonstrated potential in reducing atherosclerotic cardiovascular events, though its efficacy remains controve...
Abstract 4336615: Impact of Environmental Toxins and Socio-Economic Disparities on Cardiovascular Disease Burden: Insights from a Rural Indian Cohort Exposed to long term Industrial Pollution
Environmental degradation due to industrial groundwater contamination is an emerging cardiovascular disease (CVD) risk factor. Our study examines the elevated CVD prevalence, including heart failure (...
Abstract 4368091: Identification of therapeutic targets in heart failure with preserved ejection fraction using a novel <i>in vivo</i> screen system
Background: The complex pathophysiology of heart failure with preserved ejection fraction (HFpEF) is difficult to replicate in vitro and pre...
Abstract 4372178: Neural Connectivity Underlying Somatic Awareness in Patients with Heart Failure
Background: Neural mechanisms underlying somatic awareness involve dynamic interactions between frontal executive regions and sensorimotor areas responsible for processing bodily s...
Abstract 4363821: Drug-Coated Balloons Show Promising Improvements in Clinical Outcomes and Prognosis for Peripheral Arterial Disease: A Bayesian Network Meta-Analysis
Background and Aims: Peripheral arterial disease (PAD) is a prevalent condition caused by the narrowing or blockage of peripheral arteries, primarily affecting the lower extremitie...