Circulation
Articles in this Issue
Abstract 4373460: Clinical Effectiveness of Cerebral Embolic Protection (CEP) Devices During Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis
Introduction: Patients undergoing Transcatheter Aortic Valve Replacement/Implantation (TAVR/TAVI) are at risk of periprocedural cerebrovascular events. Cerebral Embolic Protection...
Abstract 4370058: Dynamic organization of the centrosome regulates cardiomyocyte division and maturation
Introduction: The centrosome is a key regulator of cell division, structure, and function. While it acts as the microtubule-organizing center (MTOC) in proliferating cells, differe...
Abstract 4365110: Agbaje’s Waist-to-Height Ratio Estimated Fat Mass Pediatric Cutoff Predicts Elevated Blood Pressure Risk in Multi-racial US Children and Adolescents
Background: Body mass index (BMI) masks physiologic lean mass versus pathologic fat mass effects on blood pressure (BP) in youth. Elevated BP in adolescents predicts premature card...
Abstract 4366421: Admission Cell-free DNA Predicts Cardiogenic Shock Progression and In-Hospital Mortality
Introduction: Identifying high-risk patients in cardiogenic shock (CS) has been limited by the sparse availability of biomarkers that can assist early-risk stratification. Given it...
Abstract 4369153: Interplay Between Heart Failure Progression, New-Onset Diabetes, and Finerenone: A FINEARTS-HF Analysis
Background: Heart failure (HF) and diabetes frequently co-exist, but whether worsening HF events are associated with dysglycemia and new-onset diabetes remains uncertain....
Abstract 4366610: Inhibition of PKC Improves Cerebral Microvascular Endothelial Function in Streptozotocin-Induced Alzheimer’s Disease
Introduction: Alzheimer’s Disease (AD) is associated with cerebral microvascular dysfunction and metabolic alterations. We hypothesized that activation/overproduction of PKC contri...
Abstract 4366121: Interleukin-6 Neutralization in Pulmonary Arterial Hypertension: Emerging Therapeutic Potential
Introduction: Pulmonary arterial hypertension (PAH) is a progressive and potentially fatal condition characterized by the continuous obstruction of the pulmonary arteries, which ul...
Abstract 4373020: CRISPR-Corrected iPSC Models of Pediatric LMNA Cardiomyopathy: A Meta-Analysis of Preclinical Translational Outcomes
Background: Changes in the LMNA gene are a primary cause of childhood dilated cardiomyopathy (DCM), which may lead to arrhythmias, heart failure at a young age, and the need for a...
Abstract 4335925: Clinical Level of Endothelin-1 Causes ROCK2-Mediated Constriction of Porcine Coronary Arterioles Independent of Protein Kinase C Signaling
Background: Myocardial ischemia in the absence of obstructive coronary artery disease along with diminished coronary flow reserve is diagnostic for coronary microvascular dysfuncti...
Abstract 4369040: Association of Plasma Transthyretin Levels with Risk of Heart Failure in a Multi-Ancestry Population
Background: Transthyretin (TTR) amyloidosis is a progressive disorder driven by destabilization of the TTR tetramer, leading to amyloid fibril deposition. Lower circulating TTR lev...
Abstract 4373496: Sudden Cardiac Death in Women: A 21-Year Trend Analysis by Race and Age Group Reveals Persistent Disparities
Introduction: Sudden cardiac death (SCD) is a leading contributor to cardiovascular mortality in women, yet long-term trends have been understudied particularly across menopausal t...
Abstract 4362074: Hemodynamic Resilience in Right Ventricular Intimal Sarcoma: A Rare Case of Functional Stability Despite Near-Complete RV Cavity Obstruction
Case Presentation: An 87-year-old woman with atrial fibrillation, Parkinson’s disease and cardiovascular risk factors, presented to the ED with two weeks of progressive dyspnea and...
Abstract 4370228: Targeting Mitochondrial ROS Restores Migration and Angiogenesis in Brain Endothelial Cells with Complex I Inhibition
Background: Brain microvascular endothelial cells (BMECs) are essential for maintaining blood-brain barrier (BBB) integrity and cerebrovascular homeostasis. Mitochondrial dysfuncti...
Abstract Sun1206: Emergency Medical Services Medical Director Perspectives on Intra-arrest Transport of Out-of-Hospital Cardiac Arrest: A Thematic Analysis of Expert Opinion
Background: There is considerable heterogeneity in Emergency Medical Services (EMS) agency-level use of intra-arrest transport (IAT), the act of transporting off-scene with ongoing...
Abstract 4367757: Penicillin Prophylaxis and Adherence in Latent Rheumatic Heart Disease: Systematic Review and Metaanalysis of Outcomes
Background: Although Rheumatic Heart Disease prevalence has declined in high-income countries, it remains a major cause of morbidity and mortality in low-income areas. The 2012 WHF...
Abstract 4366142: Oncologic Treatment in a Patient with Dextrocardia and Congenitally Corrected Transposition: A Personalized Approach
Background: Dextrocardia is a rare congenital anomaly in which the heart is positioned in the right hemithorax, often accompanied by complex structural abnormalities involving the...
Abstract 4369393: Gene Editing in Congenital Heart Disease Models: A 15-Year Scoping Review of CRISPR/Cas9 Applications in Human and Animal Systems
Background: Congenital heart disease (CHD) is the most common birth defect globally, yet its genetic underpinnings remain incompletely understood. Since the introduction of CRISPR/...
Abstract 4366042: The HFpEF-ABA Algorithm and Finerenone in Chronic Kidney Disease with Type 2 Diabetes: A FINE-HEART Analysis
Background: Persons with chronic kidney disease (CKD) and type 2 diabetes (T2D) face high but modifiable risks of incident heart failure (HF). The HFpEF-ABA algorithm, originally d...
Abstract 4363388: Digital Divide: Who Tracks Their Steps or Heart Rate?
Background: Wearable devices that track health indicators are increasingly recognized as valuable tools in preventing cardiovascular diseases by facilitating self-monitoring and en...
Abstract 4366402: TGF-β1-Induced Phenotypic Switch in Endothelial and Mesenchymal Plasticity: The Role of CDK5
Background: The endothelial-to-mesenchymal transition (EndMT) is a phenotypic shift wherein endothelial cells acquire proliferative, mesenchymal-like properties, contributing to en...
Abstract Sat201: Ribosome Profiling Uncovers Selective Translation in the Myocardium After Cardiac Arrest
Background: Cardiac arrest (CA) affects over 600,000 Americans every year and remains a leading cause of death in the United States. After CA, myocardial dysfunction is a common oc...
Abstract 4367082: Bridging to Delivery and Respecting Maternal Choice : Wearable Cardioverter Defibrillator Management of Sustained Ventricular Tachycardia in Pregnancy
Background: Ventricular arrhythmias during pregnancy present complex management challenges requiring careful balance between maternal safety and fetal well-being. While outflow tra...
Abstract 4362147: Mitral Annular Calcification Increases Cardiovascular Risk in Patients with Pre-existing Mitral Valve Regurgitation
Background: Mitral annular calcification (MAC) is a chronic inflammatory condition that is associated with future cardiovascular events. There is limited data that explores how MAC...
Abstract 4366307: Post-procedures outcomes of transcatheter aortic valve implantation in patients with and without diabetes mellitus: a systematic review with meta-analysis
Aims: The aim of this systematic review with meta-analysis is to evaluate the mainly cardiovascular complications of the TAVI procedure in DM patients, addressing specifically the...
Abstract 4357843: Trends and Disparities in Coronary Artery Disease Related Mortality Among Adults with Sepsis in the United States, 1999–2023
Background: Coronary artery disease and sepsis are common conditions, and both contribute significantly to mortality among adults in the United States. This study investigates tren...