Angewandte Chemie International Edition
Articles in this Issue
Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross‐Relaxation Triggers RASER of Solute Molecules
ABSTRACT Radiofrequency amplification by stimulated emission of radiation (RASER) is a phenomenon that is observed in systems of nuclear spins with strong inverse polarization beyond...
The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies
ABSTRACT Proton‐gated acid‐sensing ion channels (ASICs) are emerging therapeutic targets for ischemia‐related conditions such as stroke and myocardial infarction...
Concurrent Nucleation of Mixed‐Halide Perovskite Phase via Balancing Solvent‐PbX <sub>2</sub> Interaction for Efficient Solar Cells in Air
ABSTRACT Wide‐bandgap mixed‐halide perovskites generally used as front cell absorber play great importance for manufacturing high‐performance tandem perovskite s...
<i>Ion‐Lock</i> Storage With Multi‐Logic Circuitry Gated by Polar–Dipolar Interactions in Poly(Ionic Liquids)
ABSTRACT In these studies, we developed a new generation of polymeric materials capable of electrical energy storage and forming higher‐than‐binary logic circuit...
Adaptive Corner‐Pocket Channels in a Metal‐Organic Framework for Acetylene Ultra‐Fast Diffusion and Storage
ABSTRACT Ultra‐microporous molecular sieving materials offer exceptional size‐ and shape‐selective gas separation, yet their practical use is often limited by sl...
Promoting Oxide Pathway Mechanism on Low‐Ruthenium‐Content Oxides for Enhanced Oxygen Evolution in Proton Exchange Membrane Water Electrolyzer
ABSTRACT RuO 2 emerges as a promising alternative to IrO 2 for acidic oxygen evol...
A <i>C</i> <sub>2</sub> ‐Symmetric Chiral Emitter for Deep‐Blue Circularly Polarized Electroluminescence With High Dissymmetry Factors
ABSTRACT Deep blue circularly polarized organic light‐emitting diodes (CP‐OLEDs) remain scarce due to the stringent requirement of simultaneously achieving a wid...
Trapping a Metastable Node in an Amorphous Metal–Organic Framework
ABSTRACT We report the frustrated assembly of an amorphous metal–organic framework as a route to trap a metastable node within the network. Using x‐ray pair distribution function (PD...
An Electron Acceptor With bis(Borondifluoride)‐8‐imidazodipyrromethene as the Core for Short‐Wavelength Infrared Photoresponse
ABSTRACT Small‐molecule electron acceptors with donor–acceptor (D–A) structures have emerged as attractive materials for organic optoelectronics, yet achieving s...
Enzyme‐Mediated Dissipative Hybridization Chain Reaction (HCR)
ABSTRACT We report here a novel strategy to achieve enzyme‐mediated dissipative control over hybridization chain reaction (HCR). To achieve this, we have rationally re‐engineered a r...
Initiation: A Critical Step for High Activity and Stability in Ni‐Based Methane Dry Reforming Catalysts Supported on <i>θ</i> ‐Al <sub>2</sub> O <sub>3</sub>
ABSTRACT Ni‐based catalysts are extensively studied for the dry reforming of methane (DRM), which converts CO 2 and CH...
One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade
ABSTRACT The advancement of sustainable synthetic methodologies is a central goal of modern chemistry, given the societal importance of green chemical practices....
Chemically Synthesized H3K14Ub Unveils Clr4's IDR‐Mediated Multivalent Nucleosome Recognition in H3K9 Methylation
ABSTRACT Histone H3 lysine 9 methylation (H3K9me) is a central epigenetic mark governing heterochromatin formation. Although the H3K9 methyltransferase Clr4 has been extensively char...
Zn‐Mediated Synthesis of Sub‐5 nm PtIr─Zn Nanocubes for Direct Ammonia Fuel Cells
ABSTRACT Direct ammonia fuel cells (DAFCs) are promising for decarbonized electricity generation. However, the sluggish ammonia oxidation reaction (AOR) has long...
Implanting Lanthanide Luminophores Into Helical Scaffolds for Programmable Circularly Polarized Luminescence
ABSTRACT Integrating achiral luminophores into chiral supramolecular helices represents a promising route to strong circularly polarized luminescence (CPL). Howe...
Bond Softening and Elastic Confinement of Monolithic Dense Binary Alloys for High Volumetric Capacity of K‐Ion Battery Anodes
ABSTRACT Two‐dimensional (2D) Sb─Bi alloys are considered as the promising high‐capacity and high‐rate anodes of potassium‐ion batteries, yet their practical app...
Hydrogen‐Bonded Organic Frameworks (HOFs) for NADH Regeneration and Enzymatic Hydrogenation: HOF‐in‐HOF Artificial Photosynthetic System for Solar‐to‐Chemical Conversion
ABSTRACT The efficiency of artificial photosynthesis lies not only in the catalysts themselves, but also in the spatiotemporal landscape for efficient mass–energ...
Catalytic Enantioselective Decarboxylative Cross‐Coupling of β‐Ketoacids With <i>gem</i> ‐Difluoroallenes Enabled by Fluorine‐Induced Allylrhodium Isomerization
ABSTRACT Catalytic decarboxylative allylic alkylation (DAA) reaction represents an efficient strategy for synthesizing molecules containing both carbonyl and alk...
Discovery of a Potent and Selective Cell‐Active Inhibitor of Histidine‐N1 Methyltransferase METTL9
ABSTRACT Protein histidine N1‐methylation (1‐methylhistidine, 1‐MH) is a prevalent yet underexplored post‐translational modification in mammals. The methyltransf...
Nanozyme‐Mediated PROTACs Delivery for Targeted Protein Degradation and Ferroptosis Sensitization in Prostate Cancer
ABSTRACT Castration‐resistant prostate cancer (CRPC) remains a major clinical challenge due to its resistance to conventional androgen receptor (AR)‐targeted the...
Manganese‐Catalyzed Direct Transamination of Aliphatic Alcohols to Primary Amines
ABSTRACT Aliphatic primary amines serve as essential precursors for pharmaceuticals, fine chemicals, and functional materials. However, conventional synthetic me...
Acetal[6]Arenes: Rigid Chirality‐on‐Annulus Macrocycles Promoting Charge‐Transfer Co‐Assembly With Exceptional (Chiro)Optical Properties
ABSTRACT Acetal[6]arenes ( Ac[6] ) are introduced as a new class of rigid chiral macrocyclic arenes in which carbon‐cente...
Healing Broken S─S Bonds via <i>d</i> ‐ <i>p</i> Orbital Coupling for Durable Magnesium Batteries
ABSTRACT Rechargeable Mg batteries hold great promise for large‐scale energy storage due to the abundance, safety, and high theoretical capacity of the metallic...
Molecular‐Gate Strategy for Solid‐State Selective Recognition of Dioxane Isomers via Reversible Host–Guest and Charge‐Transfer Modulation
ABSTRACT Achieving highly selective molecular recognition in the solid state remains a major challenge in supramolecular chemistry. Herein, we introduce a molecular‐gate strategy tha...
Precise Construction of Flexible Two‐Dimensional Metal‐Organic Frameworks Through Pillar‐Ligand Tailoring for Efficient C <sub>2</sub> H <sub>2</sub> /CO <sub>2</sub> /C <sub>2</sub> H <sub>4</sub> Separation
ABSTRACT The key to achieving efficient separation of C 2 H 2 /CO...