Circulation
Articles in this Issue
Abstract 4366945: Trends in Adverse Events of Leadless Pacemakers in The United States, Between January 2021-December 2024
Leadless pacemakers (LPM) help avoid lead-related complications of transvenous pacemakers (TPM). The FDA first approved LPMs in 2016. However, studies reported more tamponades, thoracotomies, CPR, and...
Abstract 4372933: Hybrid NLP Model Accurately Extracts Data from Tetralogy of Fallot Cardiac MR Reports
Introduction: Utilization of large language models (LLMs) for named entity recognition from free-text medical reports is rapidly expanding. However, concerns about protected health...
Abstract 4369752: Incidence and Prognostic Impact of Pulmonary Embolism and Deep Venous Thrombosis in Cancer Patients Treated with Immune Checkpoint Inhibitors: A Real-World Analysis
Background: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may increase thrombotic risk through immune-mediated inflammation. While venous thromboembolism...
Abstract 4370276: Stroke Incidence Variations Among Atrial Fibrillation Patients Stratified by Cancer Subtype: A Decade of Real-World Data
Introduction: Cancer is an increasingly common comorbidity among patients with atrial fibrillation (AF), in part due to advances in treatments with improved survival. Furthermore,...
Abstract 4357915: How Thoracic Aortic Aneurysm Deaths Turned Upward After Two Decades of Progress in Older Americans: A 25-Year Mortality Analysis (1999-2023)
Background: Thoracic aortic aneurysms (TAA) are life-threatening conditions that often remain asymptomatic until rupture, resulting in >90% mortality. Despite their clinical sig...
Abstract 4358780: Plasma Metabolite Profiles of Ambient Air Pollutants and Risk of Ischemic Heart Disease: Evidence from a Prospective Cohort Study
Background: Ambient air pollution is associated with ischemic heart disease (IHD), but the metabolic mechanisms mediating this relationship remain unclear....
Abstract 4341999: Clinical Outcomes Among Individuals with Persistent Systemic Inflammation Following Myocardial Infarction: Insights from the Veterans Affairs Healthcare System
Introduction: Acute myocardial infarction (MI) triggers acute inflammation. A subset of patients experience subsequent chronic systemic inflammation (SI) post-MI....
Abstract Sun306: Veno-arterial Extracorporeal Membrane Oxygenation Outcomes in Pulmonary Embolism-Related Cardiac Arrest
Introduction: High-risk pulmonary embolism (PE) can lead to cardiac arrest, for which veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may offer life-saving cardiopulmon...
Abstract 4359108: A Bleeding Heart: Chronic Pericarditis Manifesting as Recurrent Hemorrhagic Pericardial Effusion - Diagnostic Considerations with a PFO Closure Device and the Role of CT Imaging
Background: Hemorrhagic pericardial effusion, a rare manifestation of chronic pericarditis, poses life-threatening risks, necessitating thorough evaluation. Recurrent hemorrhagic e...
Abstract 4372424: Steroid-sparing immunosuppression for MHC-mismatched allogeneic cardiomyocyte cell therapy in rhesus macaque
Background: Cardiac cell therapy with human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) is an emerging strategy to treat myocardial infarction (MI), but long-term imm...
Abstract 4370149: Oxalate Exposure Alters Mitochondrial Biogenesis and Energetic Pathways in Cardiac Myocytes
Background: Oxalate is a nonplanar anion that accumulates in the serum of patients with chronic kidney disease. In the urine, it can contribute to calcium oxalate kidney stone form...
Abstract 4363267: Development and Validation of a Prediction Model for Recurrent Atherosclerotic Cardiovascular Disease
Background: The 2018 AHA/ACC cholesterol guideline classifies a subgroup of individuals with established atherosclerotic cardiovascular disease (ASCVD) as being at “very high risk”...
Abstract 4367917: The impact of post-COVID syndrome on plasma endothelial, thrombotic and renal biomarkers
Background: Despite widespread vaccination and reduced SARS-CoV-2 pathogenicity, post-COVID syndrome (PCS) remains a significant public health issue. It is widely thought to repres...
Abstract 4365135: Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure Using WATCHMAN FLX Pro: A Preclinical Evaluation of Procedural Compatibility and Tissue Response
Background: Pulsed field ablation is a novel non-thermal energy source for pulmonary vein isolation that offers potential procedural and safety advantages over thermal modalities....
Abstract 4369165: Direct Oral Anticoagulants Do Not Prevent Stroke in Atrial Fibrillation Patients with Prior Intracerebral Hemorrhage: A Meta-analysis of Randomized Controlled Trials
Backround: There is uncertainty regarding the safety and efficacy of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients with a prior history of intracerebral h...
Abstract 4369244: AI-enabled ECG for Structural Heart Disease Diagnosis Improves Triage of Echocardiography Referral in a Low-Resource Setting: The PROVAR+ Study
Background: Echocardiography is resource-intensive, limiting its use in screening for structural heart diseases (SHD). Broader use of point-of-care ultrasound (POCUS) by trained pa...
Abstract Sun1105: Trauma center vs. nearest non-trauma center: direct transport or bypass approach for out-of-hospital traumatic cardiac arrest
Out-of-hospital traumatic cardiac arrest (TCA), caused by severe injuries such as blunt or penetrating trauma, is associated with extremely low survival rates. Around 2.7% of trauma patients experienc...
Abstract 4366212: Artificial Intelligence with Augmented Data Increases Accuracy and Speed of Heart Murmur Detection in Phonocardiogram Data
Introduction: Cardiac auscultation often provides the first indication of underlying cardiac conditions through identification of heart murmurs. Auscultation is conducted during ro...
Abstract 4361847: Prognostic Value of Systolic Blood Pressure One Year After An Acute Coronary Syndrome: Insights from the SPUM-ACS Cohort
Background: Current US and European guidelines recommend targeting a systolic blood pressure (SBP) below 130 mmHg in patients at high cardiovascular (CV) risk, such as those with a...
Abstract 4368914: Diagnostic Performance of AI-Assisted Coronary CT Angiography: A Systematic Review and Meta-Analysis
Background: Coronary computed tomography angiography (CCTA) is vital for diagnosing ischemic heart disease, yet its accuracy is affected by varying reader expertise. Artificial Int...
Abstract 4369805: Trends and Disparities in Acute Myocardial Infarction Mortality Among U.S. Adults With Heart Failure, 1999–2024
Background: Acute myocardial infarction (AMI) frequently complicates heart failure, yet national mortality trends in this population remain incompletely characterized. Understandin...
Abstract 4371708: Donor Heart Transport Technology as a Determinant of Survival in Contemporary Heart Transplantation
Background: Heart transplantation is the definitive treatment of end-stage heart failure and is a complex process involving coordination in procurement, preservation, and transport...
Abstract 4359240: Characteristics and Longer-term Outcomes of Contemporary Patients With Bicuspid Aortic Valve and Concomitant Aortopathy: A Tertiary Care Center Experience
Background: Bicuspid aortic valve (BAV) is the most common congenital defect affecting 1-2% of general population. It often presents with progressive AV stenosis/regurgitation and...
Abstract 4360720: MADIT-ICD Benefit Score – Assessing Utility in SCD-HeFT
Background: The MADIT-ICD Benefit Score (MIBS) predicts ICD VT/VF shocks vs. non-arrhythmic death and divides patients into three predicted ICD benefit groups....
Abstract 4373431: Restoring Cardiac Function with His-Purkinje Conduction System Pacing: A Meta-Analysis in Pacemaker-Induced Cardiomyopathy
Background: Chronic right ventricular pacing (RVP) can lead to electrical dyssynchrony, often resulting in pacemaker-induced cardiomyopathy (PICM). Although biventricular pacing (B...