Circulation
Articles in this Issue
Abstract 4361211: The RNA-binding protein HuR controls atherosclerotic disease progression of carotid and femoral arteries
Introduction: Peripheral artery disease (PAD) is an escalating health burden with rising incidence in aging populations driven by its strong association with cardiovascular morbidi...
Abstract 4371661: Direct Oral Anticoagulant Dual Therapy Halves Bleeding and Preserves Ischemic Protection After PCI: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Background: Patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) face a dilemma: preventing stent thrombosis while minimizing anticoagulation-relat...
Abstract 4369703: Leveraging Noise-adapted Deep Learning Algorithm to Detect Structural Heart Disease from 1-lead ECGs Acquired with KardiaMobile 6L Device: The ACCESS-SHD Study
Background: Portable devices that capture 1-lead ECG, coupled with AI tools, hold the potential to scale screening for structural heart disease (SHD) in communities. We previously...
Abstract 4342997: Transformer-Based Survival Model Outperforms Traditional Methods for Cardiovascular Risk Prediction: Analysis of Two Million Annual Health Checkup Records in Japan
Background: Cardiovascular disease (CVD) is a global health concern. Traditional models often miss nonlinear dependencies among physiological and behavioral factors. Transformer-ba...
Abstract 4367629: Cardiac Manifestations Drive Clinical Outcomes in Rare Genetic Syndromes
Background: Cardiac involvement in rare genetic syndromes frequently determines long-term prognosis yet remains inadequately characterized in clinical practice. Current management...
Abstract 4371105: Vascular Smooth Muscle Cells lacking the Insulin-like Growth Factor 1 Receptor Produce Pro-Inflammatory Extracellular Vesicles Upon Insulin Stimulation
Introduction: Diabetes Mellitus is associated with an increase in atherosclerotic plaque development. We have previously shown that extracellular vesicles derived from vascular smo...
Abstract 4336093: Effect of Aficamten in Women Compared with Men with Obstructive Hypertrophic Cardiomyopathy
Background: Women with obstructive hypertrophic cardiomyopathy (oHCM) may present with a greater burden of disease and carry a worse prognosis. Whether there are sex-related differ...
Abstract 4368039: High Prevalence of Abnormal Baseline PET Imaging for Screening of CAV in Early Post-Heart Transplant Patients
Introduction/Background: Positron emission tomography (PET) is a sensitive tool for the non-invasive assessment of cardiac allograft vasculopathy (CAV), a leading cause of long-ter...
Abstract 4369914: Successful Transfemoral TAVR in a Patient with Chronic Aortic Dissection and Severe Aortic Insufficiency
Transcatheter aortic valve replacement is a well-established treatment for high-surgical-risk patients with severe aortic disease, providing a less invasive alternative to traditional surgery. While T...
Abstract 4369179: Human Single-Cell Atlas of Pulmonary Arterial Hypertension Reveals a Novel Arterial Endothelial Subtype Involved in Plexiform Lesion Pathogenesis
Background: The cellular heterogeneity and molecular mechanisms underlying human pulmonary arterial hypertension (PAH) remain incompletely characterized. We aimed to construct a co...
Abstract 4366287: Major Adverse Cardiovascular Events across the Spectrum of Cardio-Kidney-Metabolic Syndrome: A FINE-HEART Pooled Analysis
Background: Mineralocorticoid receptor antagonists (MRAs) mechanistically reduce inflammation, oxidative stress and endothelial dysfunction. There is growing interest in understand...
Abstract 4366660: Phenotypic Conversion in a Rare Hypertrophic Cardiomyopathy Phenocopy: Longitudinal Observations Among Adolescent Patients with PRKAG2 Syndrome
Introduction/Background: PRKAG2 Syndrome is an ultra-rare non-sarcomeric hypertrophic cardiomyopathy phenocopy associated with excessive myocardial glycogen deposition, ventricular...
Abstract 4371551: Progressive Structured Simulation-based Surgical Training Program (PROCESS) - Open Vascular Surgery: Pilot Study For A Cross-over, Randomized, Double-blinded Clinical Trial.
Introduction: Vascular surgery increasingly favors endovascular procedures, yet they're not always suitable. Open vascular surgery remains crucial, but training in this area has de...
Abstract 4364213: Social Isolation, Social Support, and Cardiovascular Disease Outcomes and Risk Prediction: The Atherosclerosis Risk in Communities Study
Background: Social isolation and perceived social support have been linked to adverse cardiovascular outcomes particularly in older adults. However, their value in cardiovascular d...
Abstract 4365017: A Rare Case of Purulent Methicillin-Resistant Staphylococcus Aureus Pericarditis Presenting with Septic Shock
Description of Case: A 66-year-old man with polysubstance use and chronic kidney disease presented with dyspnea, chest pain, urinary retention, and abscesses one week after high-ri...
Abstract 4354734: Favorable Outcomes with Preoperative Extracorporeal Membrane Oxygenation Support in Emergent Pulmonary Embolectomy for Acute Pulmonary Embolism
Background: Extracorporeal membrane oxygenation (ECMO) is a last-resort therapy for patients with hemodynamic instability due to acute pulmonary embolism (PE). Some of these patien...
Abstract 4369146: Racial Disparities in Peripartum Cardiomyopathy: A Systematic Review and Meta-analysis of Risk Factors and Outcomes
Backround: Peripartum cardiomyopathy (PPCM) is a leading cause of heart failure in pregnancy and contributes significantly to maternal morbidity and mortality. Black women are disp...
Abstract 4361449: Advancing Age, ASA Class, Sex, Functional Status, and Comorbidities as Predictors of Perioperative Cardiac Arrest Following Total Hip Arthroplasty: A National Cohort Study
Introduction: Although rare, cardiac arrest during or after total hip arthroplasty (THA) is a life-threatening complication associated with substantial morbidity, ICU admissions, p...
Abstract 4367966: Clinical and Demographic Predictors of Rapid Aortic Stenosis Progression: Moving Toward Individualized Surveillance Strategies
Introduction: Aortic stenosis (AS) is the most common valvular heart disease requiring intervention in the US. Untreated symptomatic AS carries a one-year mortality rate of up to 5...
Abstract 4367391: Predictors of Clinically Relevant Genetic Variants Identification in Dilated Cardiomyopathy within a Brazilian Population Sample
Dilated cardiomyopathy (DCM) has an underlying cause associated with clinically relevant variants (CRVs) in up to 40% of cases. The Madrid Score optimizes genetic testing yield by evaluating five vari...
Abstract 4342335: Hormone Replacement Therapy and Heart Failure with Mildly Reduced Ejection Fraction in Postmenopausal Women: A Systematic Review
Background: Heart failure with mildly reduced ejection fraction (HFmrEF), defined by a left ventricular ejection fraction (LVEF) of 41–49%, is a transitional state between preserve...
Abstract 4365303: Cardiac MRI Characterization of Non-Dilated Left Ventricular Cardiomyopathy: A Comparative Study with Dilated Cardiomyopathy
Introduction: Non-dilated left ventricular cardiomyopathy (NDCM) is defined by impaired systolic function with preserved left ventricular volume. While distinct from dilated cardio...
Abstract 4363652: Contemporary Trends and Disparities in Premature Ischemic Stroke-Related Mortality in the United States, 1999–2022
Background: Ischemic stroke, responsible for 87% of all strokes in the U.S., is a major cause of death and disability. Premature mortality from ischemic stroke, defined as death be...
Abstract Sun301: Temperature control after extracorporeal cardiopulmonary resuscitation: A retrospective multicenter study in Japan
Background: The effect of temperature control after extracorporeal cardiopulmonary resuscitation (ECPR) remains unknown. This study aimed to compare the clinical outcomes and adver...
Abstract 4365545: Outcomes of Heart Failure in Muscular Dystrophies in Adults: A Nationwide Analysis in the United States
Background: Muscular dystrophies (MDs) may cause heart failure (HF), but outcomes specific to MD-related HF are not well characterized....