Circulation
Articles in this Issue
Abstract 4371605: Peripartum Arrhythmia Risk in Adults with Congenital Heart Disease: Insights from a Commercial Claims Dataset
Background: The longitudinal burden of arrhythmias during the peripartum period among adults with congenital heart disease (ACHD) remains understudied....
Abstract 4361187: Long-term follow-up of patients undergoing radial artery recanalization via distal transradial access
Background: Recanalization of occluded radial arteries via distal transradial access is being increasingly performed. However, few studies have focused on the long-term follow-up o...
Abstract 4357280: Forecasting State-Level Healthcare Costs of Atrial Fibrillation by Service Type Through 2050
Introduction: Atrial fibrillation (AF) is a growing public health concern in the United States, particularly among older adults. AF complications like stroke and heart failure resu...
Abstract 4370585: AI-based prediction of mortality in patients with ventricular tachycardia
Background: While ventricular tachycardia (VT) is frequently treated with anti-arrhythmic drugs (AADs), little is known about the impact of temporal patterns in medication exposure...
Abstract 4363023: Gαq-dependent signaling promotes atrial fibrillation through arrhythmogenic triggered calcium waves and inhomogeneous conduction in a canine heart failure model
Background: Together with conduction inhomogeneity (CI) secondary to fibrosis, arrhythmogenic triggered Ca2+ waves (TCW) are a hallmark of atrial electrophysiology in heart failure...
Abstract 4363958: Impact of Pembrolizumab on Cardiovascular Events in Cervical Cancer: A Multicenter Retrospective Cohort Study
Introduction: Pembrolizumab is a potential treatment for both locally advanced and metastatic cervical cancer with high PD-L1 expression. However, emerging evidence indicates that...
Abstract 4365593: Spironolactone and Cardiovascular Outcomes in Dialysis Patients with Heart Failure
Background: Patients with end-stage renal disease (ESRD) undergoing dialysis and with concomitant heart failure (HF) experience substantial cardiovascular risks. Although mineraloc...
Abstract 4372135: Income-stratified mortality trends of ischemic heart disease: an analysis of the GBD-2021
Purpose: This study analyzes global trends in age-standardized IHD mortality from 1990 to 2021 across Socio-Demographic Index (SDI) groups to assess income-based disparities....
Abstract 4364095: Associations Between Objective Sleep Characteristics from Wearable Physiologic Monitors and Incident Atrial Fibrillation
Background: While prior research suggests a link between sleep disturbances and atrial fibrillation (AF), few studies have utilized objective sleep measurements, including sleep st...
Abstract 4370180: A community-engaged approach to culturally tailoring a dietary intervention to improve cardiometabolic health among Black adults with obesity in Los Angeles County
Background: More than 1 in 3 adults in the United States are obese, which predisposes them to cardiometabolic (CMB) diseases such as hypertension and diabetes. These CMB diseases d...
Abstract 4370353: Prognostic Value of RV Endocardial Radiomics in Patients with Pulmonary Hypertension
Background: Right ventricular (RV) function is highly predictive of mortality in patients with pulmonary hypertension (PH). RV ejection fraction and RV end-systolic stroke volume i...
Abstract 4364005: Comparative Efficacy of Ticagrelor and Clopidogrel in Cirrhotic Patients with Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention
Introduction: Ticagrelor is a more potent P2Y12 inhibitor compared to clopidogrel and is commonly used in the treatment of stable coronary artery disease (CAD), including after per...
Abstract 4364578: Performance of Traditional Cardiovascular Risk Scores in Predicting Mortality Among Cancer Survivors
Background: Cardiovascular disease(CVD) is a leading cause of non-cancer death among cancer survivors, attributable to cardiotoxic therapies, systemic inflammation, and conventiona...
Abstract 4367712: Endothelial GPR68 Promotes Arteriogenesis and Attenuates Ischemic Injury in a Mouse Model of Peripheral Artery Disease
Background: Peripheral artery disease (PAD) results from pathological narrowing of arteries, reducing blood flow to the extremities. Shear stress sensing by endothelial cells (ECs)...
Abstract 4339045: CREG1 Alleviates Sorafenib-Induced Cardiotoxicity via the Modulation of Necroptosis
Introduction: Sorafenib (Sor), a chemotherapeutic agent widely used in the treatment of various cancers. However, its clinical application has been limited by cardiotoxicity and ad...
Abstract 4367475: Incidence and Risk of Ischemic Stroke During 3-Year Follow up in Patients Left Atrial Appendage Closure: A Real-World Multicenter Study
Background: Left atrial appendage closure (LAAC) is increasingly used as an alternative to long-term anticoagulation in patients with atrial fibrillation (AF) who are at high throm...
Abstract 4362728: Association Between Social Determinants of Health and Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults From the National Health and Nutrition Examination Survey
Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome describes the interaction between cardiovascular disease (CVD), chronic kidney disease (CKD) and metabolic syndrome. Wh...
Abstract 4366873: Health System Based Lipid Screening Clinical Pathway
Background: Pediatric dyslipidemias are among the most treatable causes of cardiovascular disease in the world. Universal lipid screening is recommended between the ages of 9 and 1...
Abstract 4365607: Time-Course Single-Cell RNA Sequencing of Patient iPSC-Derived Heart Tissue Reveals Disease-Driving Pathways in Duchenne Muscular Dystrophy–Related Cardiomyopathy
Background and Aims: Duchenne muscular dystrophy (DMD) leads to fatal cardiomyopathy caused by mutations in the dystrophin gene. Gene therapy for the heart is limited due to poor d...
Abstract 4370316: Group B Streptococcus Endocarditis: A Systematic Review Reveals High Mortality Despite Aggressive Medical and Surgical Management
Background: Streptococcus agalactiae, also known as Group B streptococcus (GBS), is an uncommon but highly virulent cause of Infective Endocarditis (IE). It is associated with elev...
Abstract 4367881: Distinct Osmolality Trajectories Are Independent Predictors of Adverse in-hospital clinical events in Acute Myocardial Infarction
Background: Dynamic changes in serum osmolality may reflect fluid imbalance, renal dysfunction, and neurohormonal activation, all of which are relevant in acute myocardial infarcti...
Abstract 4362630: Complex Signal Identification Reveals Electrical Remodeling and Predicts Early Recurrence After Atrial Fibrillation Ablation
Background: In catheter ablation for atrial fibrillation (AF), the efficacy of adjunctive ablation strategies beyond pulmonary vein isolation remains uncertain. Although complex at...
Abstract 4369901: Association of Iron Deficiency with Pre-Heart Failure in the Hispanic/Latino Population: Results from the Echocardiographic Study of Latinos (ECHO-SOL)
Introduction: Iron deficiency is a well-established comorbidity for heart failure (HF), but its role in subclinical stages of HF remains unclear. This study aimed to examine the as...
Abstract Sun601: Barriers and strategies to address layperson CPR for women: perspectives from telecommunicators
Introduction: Women receive bystander cardiopulmonary resuscitation (CPR) less frequently than men in public. Our prior work in North Carolina demonstrated that telecommunicator CP...
Abstract 4361803: Inappropriate Ventricular Fibrillation Annotation and Defibrillator Discharge During Stable Supraventricular Tachycardia: What Went Wrong?
Background: Detection of very low amplitude ("fine") ventricular fibrillation (VF) remains a challenge for implantable cardioverter-defibrillators (ICDs), as such signals may fall...