Circulation
Articles in this Issue
Abstract 4367025: Multi-omics analysis of endurance exercise reveals cardioprotective remodeling in rat heart
Background: Exercise improves cardiac health and lowers cardiovascular disease (CVD) risk, yet its protective molecular mechanisms remain incompletely understood. The Molecular Tra...
Abstract 4366772: Timing and outcomes of staged coronary artery bypass grafting following percutaneous coronary intervention for STEMI – when should we intervene?
Introduction: While recommendations exist to guide timing of coronary artery bypass grafting (CABG) following STEMI, the optimal timing of staged CABG following percutaneous corona...
Abstract 4371425: Green Space Engagement and Chronic Disease Prevalence Across Urban and Rural U.S. Communities: A Nationwide Analysis Using Mobility Data
Background: Although greenspace coverage has been widely studied in relation to chronic disease risk, less is known about actual greenspace exposure, measured by time spent visitin...
Abstract 4369683: AI-driven Measurement of Myosteatosis in Coronary Artery Calcium Scans Predicts Atrial Fibrillation and Heart Failure. An AI-CVD Study within the Multi-Ethnic Study of Atherosclerosis (MESA)
Introduction: New innovations in AI allow opportunistic detection of non-coronary features on coronary artery calcium (CAC) scans, enabling screening for a range of conditions, and...
Abstract 4364629: Comparative Outcomes of Beta-Blocker Use in Post-Myocardial Infarction Patients with EF >40%: A Retrospective Cohort Study
Background: Beta-blockers are a mainstay of therapy following myocardial infarction (MI), particularly in patients with reduced ejection fraction (EF). However, their benefit in pa...
Abstract 4350763: Baseline Severity of Coronary Artery Calcium Among Patients Enrolled in the CorCal Trial Compared to those Enrolled in the MESA Study
Background: CorCal is an ongoing clinical outcomes trial in which men over 50 and women over 60 without ASCVD, diabetes, or statins were randomized to use the Pooled Cohort Risk Eq...
Abstract 4364062: Urban-Rural Differences in Life’s Essential 8: Results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Background: Rural populations in the United States face shorter life expectancies and higher cardiovascular mortality compared to urban populations. Understanding how the American...
Abstract 4370588: Intralipid confers cardioprotection against ischemia-reperfusion injury via downregulation of NDRG1 expression
Background: Myocardial ischemia-reperfusion injury (IRI) refers to the tissue damage that occurs when blood supply returns to the heart after a period of ischemia and the sudden re...
Abstract 4368876: Proximity barcoding assay reveals dynamic plasma exosome protein profiles and subpopulation characteristics in patients undergoing transcatheter pulmonary valve replacement
Objective: Patients with congenital heart disease complicated by right ventricular outflow tract obstruction (RVOTO) often develop secondary pulmonary regurgitation (PR) after corr...
Abstract 4373046: Breaking the Clot: Restoring the flow with the ClotTriever System in Aortic Thrombosis
Aortic thrombosis (AT) is a rare but life-threatening condition that can result in ischemia, organ failure, or embolization. It presents significant management challenges, particularly in high-risk pa...
Abstract 4373227: Thyroid Dysfunction in Acute Myocarditis Is Common; Hypothyroidism Is Associated with Increased Risk of Ventricular Arrhythmias
Introduction: Thyroid dysfunction is frequently observed in patients with acute myocarditis and has been described across multiple studies. Although both conditions may share commo...
Abstract 4347306: Global Age-Stratified Burden of Cardiovascular Disease Attributable to High Systolic Blood Pressure: A Call for Targeted Attention to Young Populations
Background: The burden of cardiovascular diseases (CVD) is increasingly shifting towards younger populations. High systolic blood pressure (HBP) has emerged as the most prevalent a...
Abstract 4357888: Evaluating the Temporal and Sociodemographic Generalizability of the Emergency Heart Failure Mortality Risk Grade
Background: The Emergency Heart Failure Mortality Risk Grade (EHMRG) models are a series of clinically validated models to predict (7-day and 30-day) mortality in acute heart failu...
Abstract 4367179: Eight Novel Atrial Fibrillation Candidate Genes Identified and Validated in a De Novo UK Biobank GWAS
Background: Despite advances in large-scale GWAS and multi-ancestry meta-analyses, not all genetic contributors to atrial fibrillation (AF) have been fully identified. Foundational...
Abstract 4368568: The Frequency of False Positive Telemetry Alarms for Ventricular Arrhythmias in the Intensive Care Settings: Implications on Healthcare Resource Utilization
Background: The performance profile of commercial telemetry systems used clinically to detect ventricular tachycardia (VT) or ventricular fibrillation (VF) includes an elevated rat...
Abstract 4365816: Unmasking Hypertrophic Cardiomyopathy: Ventricular Crypts as the Earliest Clue
Background: Left ventricular (LV) myocardial crypts, defined as blood-filled invaginations penetrating >50% of myocardial thickness, remain a debated imaging finding. While asso...
Abstract 4371955: Variation in Impella 5.5 Support Duration and Ischemic Time Across Donor Transport Technologies
Background: Mechanical support strategies used for patients in shock prior to heart transplantation (OHT) correlates with post-transplant outcomes. OHT timing in patients supported...
Abstract 4371083: Weight cycling and cardiovascular risk among midlife women.
Background: While weight loss is recommended for individuals who are overweight and/or obese to reduce CVD risk, long-term weight maintenance remains challenging and may result in...
Abstract 4371414: Venous Thromboembolism in Female Hospitalizations with Intrauterine Devices (IUDs)
Background: The association between intrauterine device (IUD) use and pulmonary embolism (PE) risk in hospitalized females of reproductive age is understudied. This study assesses...
Abstract 4367010: Dual Pathway Inhibition prescription after percutaneous vascular intervention is low, and dependent on physician and treating facility practice patterns
Introduction: Industry-funded level one data supports dual pathway inhibition (DPI; aspirin and low-dose rivaroxaban) after percutaneous vascular interventions (PVI), but intervent...
Abstract 4364643: Risk Scores Only Weakly Predict Volume of Non-Calcified Coronary Plaque among People with HIV
Background/Introduction: Atherosclerotic cardiovascular disease (ASCVD) risk calculators perform poorly among people with HIV (PWH). Non-calcified coronary plaque (NCP) volume meas...
Abstract 4366246: Association of Cardiovascular-Kidney-Metabolic Syndrome Severity with Low Bone Mineral Density: NHANES 2005-2018
Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a newly defined framework describing the interconnected pathophysiology of obesity, metabolic dysfunction, kidney dise...
Abstract 4341436: Semaglutide as an effective therapy for heart failure: Evidence from a meta-analysis of 6,479 patients
Background: Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, with limited therapeutic options for improving long-term cardiovascular outcomes. Semag...
Abstract 4345555: Marital Status as a Factor in Cardiovascular Disease Risk Stratification: A Systematic Review and Meta-Analysis.
Background: Classic risk factors—such as age, sex, smoking, hypertension, hyperlipidemia, and diabetes—account for approximately 80% of the risk for cardiovascular disease (CVD). T...
Abstract 4358628: Prevalence of atrial fibrillation increases major adverse cardiovascular events, particularly heart failure hospitalization, in patients with peripheral arterial disease
Background: Peripheral arterial disease (PAD) is a leading cause of atherosclerotic disease mortality, with prevalence estimated to be 11% in the US. Studies have found that major...