Circulation
Articles in this Issue
Abstract 4368177: Body Weight–Based Latent Class Trajectories and Their Association with Left Atrial Functional Recovery Following Catheter Ablation for Atrial Fibrillation
Background: Recovery of left atrial (LA) function following catheter ablation for atrial fibrillation (AF) has been associated with favorable outcomes, such as reduced risk of recu...
Abstract 4366969: Adding a polygenic risk score to the PREVENT clinical risk tool significantly improves cardiovascular risk prediction
Introduction: Atherosclerotic cardiovascular disease (ASCVD) has many well-established risk factors; clinical risk tools (CRTs) aggregate these to estimate future disease risk. In...
Abstract 4362610: Safety, Pharmacokinetics, and Pharmacodynamics of SGB-3908, A siRNA Targeting AGT in Healthy and Mildly Hypertensive Subjects
Introduction: SGB-3908 (IBI 3016) is a GalNAc-conjugated siRNA targeting hepatic angiotensinogen (AGT), a critical upstream component of the RAAS, for hypertension. SGB-3908 utiliz...
Abstract 4368064: Improvements in Sleep and Psychological Well-Being Following a Psychoeducational Intervention Among Heart Failure Caregivers: A Secondary Analysis of the COOL HF Study
Background: Family caregivers of individuals with heart failure (HF) frequently report poor sleep and heightened psychological distress, which are linked to adverse health outcomes...
Abstract 4368573: The Implication of Sex on Clinical Long-Term Outcomes After Surgical Aortic Valve Replacement
Introduction: Previous research has found that women have higher mortality after cardiac surgery compared to men. However, research on the impact of sex on clinical outcomes after...
Abstract 4371550: Metabolic Syndrome and the Brain-Heart Axis: Insights from a Novel Heart Rate Variability Algorithm
Metabolic Syndrome (MetS) affects ~35% of the adult population in the US and increases the risk for cardiovascular complications and all-cause mortality. Altered heart rate variability occurs with Met...
Abstract 4362986: Cognitive-Behavioral Therapy for Undiagnosed OCD Dramatically Improves Medication Adherence in a Treatment-Resistant Hypertension Patient: A Case Report
Introduction: Resistant hypertension, defined as blood pressure uncontrolled despite optimal use of three or more antihypertensives, is often attributed to physiological causes. Ho...
Abstract Sat1104: Impact of Compression Rate Range on Return of Spontaneous Circulation and Survival to Discharge for In-Hospital Cardiac Arrest
Introduction: In the United States, In-Hospital Cardiac Arrest occurs approximately 292,000 times annually with high variability in survival. Code review programs allow insight int...
Abstract 4339644: Early Versus Late Initiation of Oral Anticoagulants After Ischemic Stroke in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background: Atrial fibrillation (AF) is present in approximately 20% of ischemic stroke patients. While oral anticoagulants (OACs) are effective in reducing stroke risk, the optima...
Abstract 4364190: Risk of Acute Coronary Syndrome in Rhabdomyolysis Patients With Elevated High-Sensitivity Troponin: Insights From a Matched Cohort in the TriNetX Database
The significance of elevated troponin in patients with rhabdomyolysis is debated. While some suggest skeletal muscle injury contributes to elevation, most studies indicate that elevated troponin refle...
Abstract 4368018: Association Between Hospital Teaching Status and Outcomes in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction
Background: Hospital settings may influence outcomes in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI). Understanding these disparities is crit...
Abstract 4370718: Transformer-based ECG beat foundation model reconstructs full 12-Lead morphology, vectorcardiogram and predicts peak heart rate in stress ECG
Background: Regular monitoring of performance in ECG stress tests can enable early detection of subtle conduction/morphological changes and enable more accurate risk stratification...
Abstract 4358814: Fibrinogen–Bmal1 Signaling as a Novel Therapeutic Target for Preserving Vascular Smooth Muscle Cell Contractility and Limiting Aortic Dissection Progression
Background: Aortic dissection (AD) is a life-threatening vascular disease with high mortality. Surgery is essential acutely but carries risks, whereas elective chronic surgery yiel...
Abstract 4368006: Pilot study on AI-enhanced smartwatch ECG for detecting left ventricular systolic dysfunction in real-world settings
Background: Artificial intelligence-enhanced electrocardiograms (AI-ECGs) based on single-lead recordings have demonstrated potential in detecting left ventricular systolic dysfunc...
Abstract 4362229: Trends in Incidence and Mortality of Spontaneous Coronary Artery Dissection (SCAD) from 2010 to 2024: A real world data Analysis
Background: Spontaneous Coronary Artery Dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes, particularly in younger and otherwise healthy individuals...
Abstract 4363326: Rescue of Cellular Trafficking Prevents Cardiac Dysfunction in Arrhythmogenic Cardiomyopathy
Background: Arrhythmogenic cardiomyopathy (ACM) arises from mutations in desmosomal genes, such as desmoglein (DSG) and desmoplakin (DSP), which converge into a common pathophysiol...
Abstract 4371493: Use of Congenital Heart Disease Registries for Patient Outcomes: A Cautionary Tale
Background: Congenital Heart Disease (CHD) registries-Society of Thoracic Surgeons (STS), Pediatric Cardiac Critical Care Consortium (PC4), and Pediatric Acute Care Cardiology Coll...
Abstract 4369276: Despite lower prevalence of hypertension, women have less blood pressure control than men: findings from a large electronic health-based cohort
Background: Sex differences in the burden and management of cardiovascular disease (CVD) risk factors persist despite widespread prevention guidelines. Our study examines sex diffe...
Abstract 4361412: Comparative metabolic signatures of arterial calcification in human cadaver coronary arteries and a porcine model via MALDI mass spectrometry
Introduction: Arterial calcification contributes significantly to cardiovascular morbidity, yet its metabolic mechanisms remain poorly understood. This study aimed to characterize...
Abstract 4371364: Early Left Ventricular Reverse Remodeling and Predictors of All-Cause Mortality after Successful Transcatheter Aortic Valve Replacement for Severe Symptomatic Aortic Stenosis
Background: In patients with aortic stenosis (AS), left ventricular (LV) remodeling is a complex process involving both structural and functional abnormalities, due to increased ch...
Abstract 4369269: Immune checkpoint inhibition accelerates atherosclerosis via smooth muscle cell phenotypic modulation
Immune checkpoint inhibitors (ICIs) like the FDA-approved monoclonal antibody nivolumab, which blocks the interaction between the programmed death 1 (PD-1) receptor on the surface of B and T cells and...
Abstract 4349985: Whole Patient Targeting Highly Predicts Future Stroke Events: A Risk Stratification Model for Timely Intervention in Senior Populations
Background: Hypertension is a leading contributor to stroke related events, yet most health systems lack predictive infrastructure to identify at-risk individuals early enough for...
Abstract 4364351: Impact of Alveolar Type 2 Cell-Specific Low-Density Lipoprotein Receptor-Related Protein-1 Loss in Pulmonary Fibrosis
Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by excessive collagen deposition and progressive loss of lung compliance. The prognosis is usually poor and therapeutic opt...
Abstract 4372279: Resistant Hypertension and BP Trajectories: EHR Insights into PA and OSA Screening Practices
Introduction: Primary aldosteronism (PA) and obstructive sleep apnea (OSA) are common, treatable causes of secondary hypertension. Guidelines recommend screening for PA in resistan...
Abstract 4373470: COX-1 RELATED THROMBOXANE OVERPRODUCTION IN ELDERLY PATIENTS WITH ATRIAL FIBRILLATION
Introduction and hypothesis: Aging is associated with an increased incidence of cardiovascular events. Recent evidence suggest that platelets from older subjects differ in function...