Circulation
Articles in this Issue
Abstract 4365007: Artificial Intelligence (AI) Models Effectively Detect Cancer Therapy-Related Cardiac Dysfunction (CTRCD): a Diagnostic Test Accuracy (DTA) Meta-Analysis
Background: Significant advances in cancer diagnosis and treatment, have yielded improved survival among cancer patients. This predisposes patients to cardiovascular compromise, wh...
Abstract 4361241: Prevalence of cardiometabolic conditions across body mass index categories—the distinct burden of severe (class III) obesity
Background: Cardiometabolic (CM) conditions are a recognized complication of obesity, although their comparative burden among patients with severe (class III) obesity is less well...
Abstract 4369545: Differential impact of aging on cardiovascular disease risk in male military service members
Introduction: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in male service members and veterans. This study assessed the 10-year ASCVD risk in male...
Abstract 4359647: Results of Pilot Trials in the United States and Phase I Bridging Trials in China of a Novel Antiplatelet P2Y12 Inhibitor Evategrel (CG-0255)
Evategrel (CG-0255) is world’s first thioether prodrug relying only on carboxylesterases for metabolizing to its active metabolite, which is identical to clopidogrel’s active metabolite H4 generated t...
Abstract 4370748: Evaluation of the Prognostic Value of Resting Fick and Thermodilution Cardiac Output and Exercise Cardiac Output Measurements in Heart Failure
Background: Invasive hemodynamics are the gold standard for heart failure (HF) evaluation, with cardiac output (CO) representing a key indicator of HF severity. Among outpatients w...
Abstract 4370852: Impact of Diabetes Mellitus on Cardiovascular Outcomes in Patients with Elevated Lipoprotein(a): A US Retrospective Cohort Analysis
Background: Lipoprotein (a) (Lp(a)) and diabetes mellitus (DM) are both established risk factors for the development of cardiovascular disease. However, there is limited data regar...
Abstract 4364588: GLP-1 Receptor Agonist in Patients Undergoing Percutaneous Left Atrial Appendage Occlusion: Impact on Outcomes
Background: Patients undergoing percutaneous left atrial appendage occlusion (LAAO) for atrial fibrillation often have comorbid diabetes and obesity. GLP-1 receptor agonists provid...
Abstract 4369614: Ethnicity-Based Response in Systolic Blood Pressure Response in Post-Renal Denervation patients: A Meta-Analysis
Introduction/Background: Renal denervation (RDN) is an upcoming interventional procedure for resistant hypertension. However, most major RDN trials have disproportionality in enrol...
Abstract 4363426: Artificial Intelligence-Based Optical Mapping Identifies Active Pulmonary Veins and Outcomes from Atrial Fibrillation Ablation
Background: A major hurdle in improving atrial fibrillation (AF) ablation is reliably identifying patient-specific targets. Mapping based on electrograms (EGMs) has had mixed resul...
Abstract 4360792: Cell Painting Based High-Content Phenotypic Screening To Elucidate Kinase Signaling Pathways in BTK-Inhibitor Mediated Atrial Fibrillation
Introduction: One goal of Precision Cardio-Oncology is to identify and ultimately clinically exploit a fundamental understanding of shared signaling pathways in cardiovascular dise...
Abstract 4366580: Using a proteomics-based test to assess cardiovascular risk in individuals with clonal hematopoiesis of indeterminate potential (CHIP)
Background: Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon associated with increased cardiovascular (CV) risk, independent of traditional risk...
Abstract Sat507: Knowledge retention and safety in decision-making in basic life support maneuvers by professionals in public elementary education after training conducted by academics in the health field
Introduction: This abstract addresses the application of Law 13,722/18, “Lei Lucas” (Lucas Law), which requires first aid training for education professionals. Despite its enforcem...
Abstract 4368872: SGLT-2 inhibitors in pediatric heart failure, congenital heart disease and adults with congenital heart disease – a systematic review
Introduction: SGLT-2 inhibitors, initially intended to treat diabetes, have had efficacy in adult trials to reduce mortality and morbidity with heart failure (HF). This mediations...
Abstract 4354762: Safety and feasibility of magnetic resonance imaging within the first week following transvenous pacing system implantation
Introduction: Patients with transvenous cardiac implantable electrical devices (CIEDs) including pacemakers are typically excluded from magnetic resonance imaging (MRI) examination...
Abstract 4370598: Machine Learning Models to Predict High Atrial Fibrillation Burden Post-Catheter Ablation in Patients with Persistent AF: Insights from the DECAAF II Trial
Background: High atrial fibrillation (AF) burden is associated with increased risk of stroke and heart failure. While catheter ablation reduces AF burden in most patients, a minori...
Abstract 4359059: Hemolysis-Triggered CLIC1/RALY Axis Promotes Endothelial-to-Smooth Muscle Cell Crosstalk in Pulmonary Hypertension
Background: Pulmonary hypertension (PH) is a progressive and life-threatening vascular disorder characterized by elevated pulmonary arterial pressure, and right ventricular (RV) hy...
Abstract 4365000: Characterization of Plasma Proteins Associated with Arterial Stiffness and Pressure Pulsatility
Background: Stiffening of large arteries is a key pathophysiologic precursor of micro- and macrovascular disease. Increased arterial stiffness (AoS) and central pressure pulsatilit...
Abstract 4364344: Chronotropic Incompetence Predicts Reduced Survival and Exercise Capacity in Heart Failure: A Meta-Analysis of Reconstructed Time-to-Event Data Across HFrEF and HFpEF
Background: Chronotropic incompetence (CI) is the inability of the heart to increase its rate adequately during activity. It is common in heart failure (HF) patients and is associa...
Abstract 4359269: Hearts to Home: A Framework for Understanding and Improving Discharge Efficiency in the Pediatric Acute Care Cardiology Collaborative
Background: Delayed discharges from pediatric acute care cardiology units causes inefficient use of hospital resources, increased healthcare costs, and family dissatisfaction. Pati...
Abstract 4367248: IJ Central Line Duration and Catheter Size-to-Weight Ratio are Thrombosis Risk Factors in Infants Undergoing Cardiothoracic Surgery
Introduction: Internal jugular (IJ) venous catheters placed for cardiothoracic (CT) surgery in infants are associated with an increased risk of thrombosis, contributing to signific...
Abstract 4356423: Feed-forward regulation of the stress response protein REDD1 by GSK3β and NF-κB in diabetic cardiomyopathy
Introduction: Prior studies support a potential role for the stress response protein regulated in development and DNA damage 1 (REDD1) in cardiac function deficits caused by diabet...
Abstract 4368538: Fusion Machine Learning Architectures for Improving ECG classification of acute coronary events
Introduction: Acute coronary syndrome (ACS) is a life-threatening emergency, with occlusion myocardial infarction (OMI) requiring rapid diagnosis and treatment. The 12-lead ECG rem...
Abstract 4373490: Trends in Out-of-Pocket Spending for Drugs Under Medicare Part D in Coronary Artery Disease and the Impact of the Inflation Reduction Act
Introduction: Coronary artery disease (CAD) is common among Medicare beneficiaries, often requiring chronic use of both low-cost generics (e.g., statins, nitrates) and high-cost br...
Abstract 4370224: Partial Anomalous Pulmonary Venous Return: An Uncommon Cause of Refractory Hypoxemia Following Coronary Artery Bypass Grafting
Background: Severe hypoxemia after coronary artery bypass grafting (CABG) is a critical complication. Common preoperative risk factors include chronic pulmonary disease, myocardial...
Abstract 4360378: Characterization and Translational Potential of a Nonhuman Primate Model of Heart Failure with Renal Disease: Insights into Cardio-Renal Syndrome Progression
The anatomical and physiological congruence of cynomolgus macaques ( Macaca fascicularis ) to humans make them valuable models for translational research into h...