Circulation
Articles in this Issue
Abstract 4357581: Prophylactic Left Atrial Appendage Occlusion During Mitral Valve Repair in Patients Without Atrial Fibrillation: A Meta-Analysis with Reconstructed Time-to-Event Data
Background: Mitral valve repair (MVr) is the standard treatment for degenerative mitral regurgitation and is associated with favorable long-term outcomes. However, postoperative at...
Abstract 4366940: Phosphate Reduction During Hemodialysis Is Associated with Worsening Left Ventricular Global Longitudinal Strain
Introduction: Patients receiving hemodialysis (HD) experience higher mortality on dialysis days, implicating potential dialysis-specific factors. Phosphate is a critical component...
Abstract 4371741: Gender Differences in Authorship of Leading Interventional Cardiology Publications
Background: Despite progress in the representation of female cardiology trainees and physicians over time, women remain underrepresented in published cardiology literature....
Abstract 4373276: Global Trends in Ischemic Heart Disease Attributable to Kidney Dysfunction: A 204-Country Analysis of Mortality and Disability from 1990 to 2021
Background: Kidney dysfunction is an under-recognized yet growing contributor to ischemic heart disease (IHD) burden worldwide. As chronic kidney disease (CKD) prevalence rises glo...
Abstract 4357760: Preoperative Daily Step Count and Cognitive Performance Following Cardiac Surgery
Background: Cognitive decline is a common complication of cardiac surgery, linked to reduced quality of life and increased mortality. Even early, transient deficits are associated...
Abstract 4361952: Comparison of County-Level Social Disadvantage Indices and Hypertension Hospitalizations Among Medicare Beneficiaries
Background: Community-level social disadvantage is a recognized determinant of adverse cardiovascular outcomes, yet its relationship with hypertension-related hospitalizations (HTN...
Abstract 4367188: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease
Background: Cardiovascular disease (CVD) causes more than 50% of deaths in patients with advanced chronic kidney disease (CKD). Clinical studies suggest that kidney-derived factors...
Abstract 4366123: Impella Use in AMI-Related Cardiogenic Shock is Associated with Increased Mortality and Complications Compared to Intra-Aortic Balloon Pump: A Propensity-Matched Real-World Analysis
Background: Mechanical circulatory support is often employed in acute myocardial infarction (AMI) complicated by cardiogenic shock. While Impella and IABP are widely used, real-wor...
Abstract 4360094: Trends in Hypertension-Related Heart Failure Mortality in the United States (1999–2020): A Population-Based Study
Background: Hypertension is increased blood pressure above 140/90mmHg. Novel therapeutics toward Hypertension have shown improvement in cardiovascular activity. However, patients w...
Abstract 4362976: Serotonin reduction decreases apneas and the hypercapnic ventilatory response in ischemic heart failure mice
Background: Central apneas are highly prevalent in heart failure (HF), contributing to morbidity and mortality. Increased hypercapnic ventilatory response (HCVR) is a primary patho...
Abstract 4345815: Altered Cortical Electroencephalography Activity in Heart Failure
Introduction: Heart failure is associated with reduced cardiac output and cerebral hypoperfusion, which may disrupt neural activity in the brain. Resting electroencephalography (EE...
Abstract 4371463: Cuffless Blood Pressure Monitoring Using a Novel Wrist-Worn Photoplethysmography Device: Validation Against Intra-Arterial Blood Pressure
Background: Cuffless blood pressure (BP) monitoring devices with the ability to continuously and noninvasively collect data could transform the screening and management of hyperten...
Abstract 4366334: Baseline Ejection Fraction and Concurrent Treatments Predict Risk of Cancer Therapy Related Cardiac Dysfunction Following Immune Checkpoint Inhibitor Therapy
Background: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are associated with adverse effects. Incidence, predictors and timing of cancer therapy-relate...
Abstract 4362097: Uncovering 24-Hour Hemodynamic Phenotypes: Synchronization Patterns in Cuff-less Ambulatory Blood Pressure Monitoring
Introduction: Twenty-four-hour ambulatory blood pressure monitoring (ABPM) offers a more accurate reflection of blood pressure (BP) behavior and cardiovascular risk than office mea...
Abstract 4361671: Substance Use Disorder and Atrial Fibrillation–Related Mortality Trends and Disparities Among Adults Aged ≥ 25 Years in the United States from 1999–2020: A CDC WONDER Database Analysis
Introduction: Substance abuse disorder (SUD) combined with atrial fibrillation (AF) results in dire patient outcomes and accelerated mortality. Research on the combined mortality t...
Abstract 4371170: Diagnostic Evaluation of Pulmonary Embolism Prior to Pulmonary Embolism Response Teams Implementation: A Retrospective Single-Center Study
Introduction: Pulmonary embolism (PE) is the third most common cardiovascular disease.Acute right ventricular (RV) failure due to pressure overload is the leading cause of death in...
Abstract 4349153: Genicular Artery Embolization for Knee Osteoarthritis: A Systematic Review of Sham-Controlled Randomized Trials
Background: Knee osteoarthritis (KOA) is associated with significant chronic pain and functional impairment. Genicular artery embolization (GAE), a minimally invasive procedure, ta...
Abstract 4360949: Heat-shock Protein HSPA5 and HSP90B1 Were Upregulated in Pig Cardiomyocytes Responding to Apical Resection on Postnatal Day 1 and Promoted Cardiomyocyte Cell-cycle
Background: Understanding mechanisms activating the cardiomyocyte (CM) cell-cycle in large mammals is essential to designing molecular therapies for treating injured hearts. Pig CM...
Abstract 4362328: The Hypertrophic Heart That Told Two Stories: A Case of Coexisting Hypertrophic Cardiomyopathy and Fabry Disease
Background: Fabry disease is a rare lysosomal storage disorder that frequently presents with concentric left ventricular hypertrophy, mimicking sarcomeric hypertrophic cardiomyopat...
Abstract 4361230: Pulse Field Ablation Have A Mild Impact on Atrial Fibrillation Ablation Workflow And Organization: A Single High-Volume Center Experience
Introduction and Background: Pulsed field ablation (PFA) is a new non-thermal energy source with a selective effect on myocardial cells that limits damage to other tissues. Because...
Abstract 4367790: Safety and Efficacy of Intravenous Tenecteplase Prior to Mechanical Thrombectomy in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Background: Intravenous thrombolysis before mechanical thrombectomy may enhance reperfusion before, during, and after the procedure but also increase the risk of intracranial hemor...
Abstract 4371358: Simultaneous Heart-Kidney Transplantation Before and After the 2023 UNOS Policy Change
Background: Simultaneous heart-kidney transplantation (SHKT) is the preferred therapy for patients with combined heart and kidney failure. In 2023, the United Network for Organ Sha...
Abstract 4369789: Sex differences in short-term PE outcomes in older adults: The SERIOUS-PE Multinational Study
Background: Several studies have assessed sex differences in outcomes of patients with pulmonary embolism (PE). However, they have been limited by small sample sizes, lack of a pre...
Abstract 4346320: Communication by Specialty, Seniority, and Gender During Congenital Heart Center Medical Decision-Making Conferences
Background: Congenital heart centers commonly use team decision-making conferences to choose interventional or medical strategies for patients. These conferences crucially impact c...
Abstract 4366283: Increased Immune Cell-Cell Communication and Pro-Inflammatory Signaling in Clonal Hematopoiesis of Indeterminate Potential (CHIP)-Positive Peripheral Blood in Immune Checkpoint Inhibitor Myocarditis
Introduction: Clonal hematopoiesis of indeterminate potential (CHIP) was recently shown to be an independent risk factor for immune checkpoint inhibitor (ICI)-associated myocarditi...