Circulation
Articles in this Issue
Abstract 4367854: The impact of viral infection with SARS-CoV-2 and influenza on plasma endothelial, thrombotic and renal biomarkers
Background: SARS-CoV-2 and influenza infections are associated with an increased risk of cardiovascular events. While the underlying mechanisms remain incompletely defined, mountin...
Abstract 4364577: Climbing the Academic Ladder in Pediatric Cardiology: Career Advancement, Fulfillment and Challenges - A Survey Study
Introduction: Professional fulfillment, work-life balance and recognition of productivity are central to advancing the specialty. Early signs of burnout among pediatric cardiologis...
Abstract 4338231: Inclisiran Nonresponse with PCSK9 Variant and Successful LDL-C Lowering with Evinacumab in a Patient with Homozygous Familial Hypercholesterolemia
Background: Patients with homozygous familial hypercholesterolemia (HoFH) often require intensive lipid-lowering therapies (LLT) to prevent ASCVD. Inclisiran, a small interfering R...
Abstract 4369657: Effectiveness of Exercise Training and Training Parameters on Heart Rate Variability in People with Cardiovascular Disease: A Systematic Review and Meta-analysis.
Background: Heart rate variability (HRV) is a sensitive marker of autonomic dysfunction and an independent predictor of mortality in cardiovascular disease (CVD). While structured...
Abstract 4365455: Outcomes of Transcatheter Edge-to-Edge Repair of the Mitral Valve in Cirrhosis: A TriNetX Based Global Study
Introduction: Transcatheter Edge-to-Edge Repair (M-TEER) is a safe and effective intervention for both primary and secondary mitral regurgitation. Cirrhosis, a common and high-risk...
Abstract 4366225: Proteomic Signatures of Lipoprotein (a) Particles Reveal Novel Associations with Plasma Levels and KIV-2 Copy Number in an Elderly Multiethnic Cohort
Background: High lipoprotein(a) [Lp(a)] is a causal risk factor for Atherosclerotic Cardiovascular Disease, yet the mechanisms driving this risk remain unclear. Lp(a) levels are la...
Abstract 4372986: Modeling Pediatric Inherited Cardiomyopathies Using Human iPSC-Derived Cardiac Organoids: A Systematic Review and Meta-Analysis
Background: Inherited cardiomyopathies (ICMs), including hypertrophic (HCM) and dilated (DCM), are key contributors to pediatric heart failure and sudden cardiac death. Human induc...
Abstract 4361441: Temporal Trends in Cardiometabolic Risk Among U.S. Women Veterans: Widening Racial and Age-Based Disparities over a 20-year period
Introduction: Cardiometabolic risk factors remain the leading cause of cardiovascular disease (CVD) and death in the US. US women veterans (WV) are a growing, high-risk population...
Abstract 4341756: Aortic Root Pseudoaneurysm Following Bicuspid Aortic Valve Endocarditis and Root Reconstruction
Background: Aortic root pseudoaneurysm is a rare but life-threatening complication of cardiac surgery or infective endocarditis. Early diagnosis and surgical repair are vital due t...
Abstract 4367539: An Analysis of Ischemic Heart Disease Mortality Trends Attributable to High Body Mass Index in High-Income Countries: Global Burden of Disease Study from 1990-2021
Introduction: Ischemic heart disease attributable to high body mass index (IHD-BMI) is a major health concern, often resulting in irreversible myocardial damage, progressive ventri...
Abstract 4369523: A Novel Bioreactor to Model Time-Varying Mechanical Preload and Afterload in Engineered Cardiac Tissues
Introduction: During postnatal development, the heart undergoes continuous adaptation to mechanical loads—primarily preload (stretch experienced during chamber filling) and afterlo...
Abstract 4361432: Cardiovascular Health and Unrecognized Cardiovascular Risk among People Released from Prison: Baseline Findings from the SCHARP Prospective Cohort Study
Background : Compared to the general population, people released from prison suffer two times higher cardiovascular (CV) mortality and have an increased risk of CV events after rel...
Abstract 4373204: Placental-derived Senescence Associated Secretory Proteins Increase Atrial Fibrillation Susceptibility in Pregnancy
Introduction: Structural heart disease, including peripartum cardiomyopathy (PPCM), is associated with increased atrial fibrillation (AF) risk during pregnancy. Our group recently...
Abstract 4368970: Remote Patient Monitoring Lowers Healthcare Expenditures and Utilization in a ACO Cross-Sectional Cohort Study
Background: Accountable Care Organizations (ACOs) assume financial risk for total cost of care under value-based payment models and require scalable interventions to reduce high-co...
Abstract 4368020: Derivation and Validation of a Machine Learning Approach for Preeclampsia Phenotyping
Background: Preeclampsia is a heterogeneous disorder, with emerging evidence indicating the presence of multiple phenotypes. Identifying distinct clinical phenotypes may facilitate...
Abstract 4362448: Environmental Exposure to Toxic Metals and Cardiovascular Diseases Outcomes from 2015-2023: A Mixture Analysis
Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally. Toxic metals are widespread environmental contaminants and may play a role in the d...
Abstract Sat805: Six Month Follow-up after Community Bystander Cardiopulmonary Resuscitation Training with Traditional and Breasted Manikins
Introduction: Prior research has shown that females are less likely to receive CPR in an out-of-hospital cardiac arrest (OHCA). Yet, many community CPR trainings do not use breaste...
Abstract Sat602: Temporal Trends in Outcomes of Out-of-Hospital Cardiac Arrest Patients With or Without Cerebrovascular Accidents
Backgrounds: Recent advances in treatment have improved outcomes in patients with cerebrovascular accidents (CVA). Out-of-hospital cardiac arrest (OHCA) secondary to CVA is relativ...
Abstract 4368089: Impact of Advanced Mechanical Circulatory Support on Hemodynamics and Oxygen Delivery in Ventricular Septal Perforation with Severe Biventricular Failure: A Systematic Simulation Study
Introduction: Post-myocardial infarction ventricular septal perforation (VSP) with cardiogenic shock often requires mechanical circulatory support (MCS) to stabilize hemodynamics....
Abstract 4361496: Noninvasive Respiratory Support After Cardiothoracic Surgery: A Network Meta-analysis
Background: Cardiothoracic surgery is associated with a high incidence of postoperative respiratory complications arising from a combination of patient-related and procedural risk...
Abstract 4343073: Seasonal Disparities in Cardiovascular Mortality: Analyzing Winter Excess Across Demographics and Regions (2018–2023)
Background: Seasonal variations in cardiovascular mortality have been documented, with higher rates observed during winter months. This study examines winter-summer disparities in...
Abstract 4368561: Mavacamten: Real-World Experience from 34 Months of the Risk Evaluation and Mitigation Strategy (REMS) Program
Introduction: Mavacamten is a first-in-class cardiac myosin inhibitor approved by the FDA for the treatment of adults with symptomatic New York Heart Association (NYHA) class II–II...
Abstract 4365627: Building Clinical Consensus on the Management of Cardiovascular Disease Risk in Obesity: An Initiative of the National Heart Foundation of Australia
Background: Obesity has become a critical health challenge, now affecting over a billion people globally. In Australia, approximately two-thirds of adults are living with overweigh...
Abstract 4368013: Trends in Stroke and Cancer-Related Mortality in the United States from 1999 to 2023
Background: Stroke is the fifth leading cause of mortality in the United States (US), with diverse etiologies. Evidence suggests that cancer is a significant predisposing factor, w...
Abstract 4344084: Plasma Protein N-Glycosylation Profiles Are Associated with Future Cardiovascular Events: Analyses from the JUPITER and TNT Trials
Background: Glycosylation—a key post-translational modification—plays a critical role in biological pathways of atherosclerosis. We previously demonstrated associations between N-g...