Circulation
Articles in this Issue
Abstract 4355875: Social determinants of health screen rates, positive screens, and outcomes for cardiovascular patients within a large health network in Oregon
Background: Social determinants of health (SDOH) are tied to cardiovascular disease (CVD) prevalence, disease progression, and outcomes. New federal and Oregon requirements mandate...
Abstract 4341751: Outcomes Associated with Infective Endocarditis in Cardiac Intensive Care Unit Patients
Introduction: Infective endocarditis (IE) is a severe intracardiac infection, often requiring intensive care unit (ICU) admission. Despite early surgical intervention, mortality re...
Abstract 4368054: Gender and Racial Disparities in Heart Transplantation Under the Updated US Regulations: Multicenter Analysis
Background: Racial and gender disparities in heart transplant access and outcomes were well documented prior to 2018. On October 18, 2018, the United Network for Organ Sharing (UNO...
Abstract 4363153: Leveraging Large Language Models to Extract Unstructured Cardiovascular Data from the EHR for Preventive Cardiology
Background: Preventive cardiology relies on a comprehensive view of patient health, including biomarkers and imaging findings. However, critical data, such as coronary calcium scor...
Abstract 4364408: Protein Arginine Methyltransferase 5 Drives Pulmonary Arterial Remodeling in Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease characterized by excessive proliferation and reduced apoptosis of pulmonary arterial smooth mus...
Abstract 4369473: Following the implementation of a prevention policy : Improved survival after sudden cardiac arrest in train stations.
Background: Due to the high passenger flow, train stations are at high risk sites for sudden cardiac arrest (SCA) occurrences. Recognizing the importance of early defibrillation an...
Abstract 4364159: The Heart in the Crossfire: Nationwide Insights on Cardiovascular Complications of Cytokine Release Syndrome
Cytokine release syndrome (CRS) is a systemic inflammatory response marked by the excessive release of pro-inflammatory cytokines, commonly triggered by immunotherapies such as CAR T-cell therapy. Car...
Abstract 4348304: Unsupervised Machine Learning Identifies Distinct Clinical Phenotypes in Acute Heart Failure Hospitalizations: A Nationwide Study Using the National Inpatient Sample
Background: Heart failure has traditionally been classified as systolic vs diastolic, however acute heart failure (AHF) hospitalizations, often has various outcomes seen in bedside...
Abstract 4368240: Increased Number of B-Lines on Lung Ultrasound Is Associated with Elevated Filling Pressures and Adverse Outcomes in Acute Heart Failure
Background: B-lines on lung ultrasound (LUS) are useful for identifying pulmonary congestion in acute heart failure (AHF), but their relationship with detailed cardiac structure an...
Abstract 4368504: Concordance Between In-Office versus At-Home Systolic Blood Pressure Reductions in RPM-Engaged Patients with Uncontrolled Hypertension
Background: Remote patient monitoring (RPM) devices aim to improve hypertension management by providing frequent readings outside clinic, but validation comparing home versus in-of...
Abstract 4364406: Basal Septal Premature Ventricular Contractions are associated with Complete Heart Block Development: Case Series
Background: Premature ventricular contractions (PVCs) are one of the most common arrhythmias and can be associated with increased risk of mortality and major cardiovascular events...
Abstract 4361233: Interposed Abdominal Compression CPR Associated With Improved Hemodynamic and Clinical Outcomes: A Systematic Review and Meta-Analysis
Background: Interposed abdominal compression cardiopulmonary resuscitation (IAC-CPR) has been proposed as a novel approach to augment forward blood flow and improve resuscitation o...
Abstract 4369001: Circadian Disruption by Shift Work Drives Aortic Valve Calcification Through BMAL1-SEMA6D-PPARγ Axis Inhibition
Background: Calcific aortic valve disease (CAVD) is a leading cause of heart failure and cardiovascular mortality worldwide. While disruption of circadian rhythm by means of shift...
Abstract 4366272: Optically-Measured Critical Closing Pressure is a Non-invasive Proxy of Central Venous Pressure in Children with Single-Ventricle Congenital Heart Disease
Introduction: Children with single-ventricle heart disease undergo a series of palliative surgeries that result in passive pulmonary blood flow. To maintain pulmonary blood flow, t...
Abstract 4371805: False-Positive Aortic Intimal Flap on Echocardiography in an Asymptomatic Adolescent: Clinical Correlation Prevents Misdiagnosis
Background: Echocardiography is frequently used as a first-line imaging tool for aortic evaluation, but its susceptibility to artifacts can lead to false-positive findings. Aortic...
Abstract 4344020: Mechanical Complications in STEMI: A Comparative Study of COVID-19 Positive and Negative Patients
Background: Acute MI is associated with significant immediate mortality however a second wave of morbidity and mortality arises from mechanical complications which include papillar...
Abstract 4370254: Proteomic Markers Associated with Early Pregnancy Stress and Adverse Pregnancy Outcomes
Introduction: Psychosocial stressors in early pregnancy are associated with a higher risk of adverse pregnancy outcomes (APOs), including hypertensive disorders of pregnancy (HDP),...
Abstract 4346928: Recurrent Triple Vessel Spontaneous Coronary Artery Dissection following GLP-1 Receptor Agonist Use
Introduction: Spontaneous coronary artery dissection (SCAD) is an infrequent but increasingly recognized cause of myocardial infarction that disproportionately affects women. SCAD...
Abstract 4366436: Internet Addiction and Early-Life Risk Indicators for Cardiometabolic and Mental Health Disorders
Background: 94% of US adolescents ages 9-18 experience internet use (IU), averaging 5-7 hours of entertainment use daily. Studies have linked IU and internet addiction (IA) to obes...
Abstract 4361408: Amyloid Pathway Markers and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Background: Amyloid beta 1–40 (Aβ1–40), a cleavage product of amyloid precursor protein, is emerging as a vascular inflammation marker with prognostic value in cardiovascular disea...
Abstract 4368849: Comparative Transcriptomic Analysis of Atrial Chambers in Atrial Fibrillation
Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with progressive atrial remodeling. Although clinical interventions often target the...
Abstract 4360293: TNFR Pathway-Related Proteins are Associated with Recurrent Coronary Artery Disease Events
Background: Despite optimization of coronary artery disease (CAD) related factors with lifestyle modifications and medications, complications of CAD are the leading cause of death...
Abstract 4365117: A Diagnosis Dilemma of Positional Hypoxia: Scoliosis-Mediated Platypnea-Orthodeoxia Syndrome
Description of Case: A 78-year-old man with a history of Parkinson’s, TIAs, and scoliosis presented with a sequalae of symptoms concerning for recurrent TIA, however extensive work...
Abstract 4364153: Cohort-scale automated patch clamp data improves variant classification and penetrance stratification for <i>SCN5A</i> -Brugada Syndrome
Introduction: Genetic data are transforming preventative cardiology by identifying individuals at risk of disease before sudden manifestations. Brugada Syndrome (BrS) is an inherit...
Abstract 4371509: Long-term Flecainide Exposure Triggers Expression of Neuronal Sodium Channels in the Murine Heart
Introduction: Class IC antiarrhythmic agents are widely used to treat arrhythmias. However, in the CAST trial these drugs increased arrhythmic mortality in patients with recent myo...