Circulation
Articles in this Issue
Abstract 4369292: Sex Differences in the Association between Co-Exposure to Air Pollution and Major Adverse Cardiovascular Events among Patients with Heart Disease
Introduction: Air pollution is recognized as an important environmental risk factor for cardiovascular risk, but how combined measures of air pollution contribute to this risk and...
Abstract 4368027: Trends of Cardiomyopathy attributable to high alcohol use across 204 Countries and territories: Comparative Global Analysis from the Global Burden of Disease 2021
Introduction: Cardiomyopathies are a group of pathological disorders that lead to heart failure and ultimately death. Among multiple risk factors, high alcohol consumption is one o...
Abstract 4365902: Heart Failure in Anti-MDA5 Dermatomyositis: A Rare Manifestation of an Amyopathic Inflammatory Myopathy
Background: Anti-MDA5 dermatomyositis is a rare subtype of idiopathic inflammatory myopathy with high mortality, often due to interstitial lung disease (ILD). Myocardial involvemen...
Abstract Sun902: Variations in Refibrillation across Different AED User Groups in Out-of-Hospital Cardiac Arrest
Introduction: AEDs are essential in diverse out-of-hospital cardiac arrest (OHCA) scenarios. After a successful defibrillation, refibrillation occurs frequently and poses challenge...
Abstract 4371211: Impact of Aspirin Use on Amputation Outcomes and Cardiovascular Risk in Peripheral Artery Disease Patients: Insights from a High-Risk Cohort
Background: Aspirin therapy is well-established for secondary prevention of cardiovascular events; however, its role in modifying amputation outcomes in patients with peripheral ar...
Abstract 4360803: Visible-Light Optical Coherence Tomography Reveals Atenolol-Induced Vascular Remodeling in the Mouse Eye
Introduction: Atenolol is a widely prescribed beta-blocker for managing systemic hypertension, but its potential impact on ocular microvasculature remains poorly understood. Invest...
Abstract 4370217: Biased small molecule RXFP1 agonists ameliorate experimental pulmonary hypertension and RV hypertrophy
Background: Human Relaxin-2 (RLN2) signals via G-protein coupled receptor (GPCR) relaxin family peptide receptor 1 (RXFP1), and exerts vasodilatory, anti-inflammatory, and anti-fib...
Abstract 4364678: A Rare Case of Self-Resolving Pheochromocytoma-Induced Reverse Takotsubo Cardiomyopathy Due to Tumor Hemorrhagic Conversion
Case: A 38-year-old woman with a history of migraine headaches, a stable intracranial aneurysm, no recent stressors and a prior normal echocardiogram and ECG presented with 2 years...
Abstract 4365799: Group Virtual Care for Women with Cardiovascular-Kidney-Metabolic Syndrome: Engagement and Lifestyle Change in a Scalable Model
Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome is a growing public health challenge marked by rising morbidity, mortality, and healthcare costs. Traditional care mode...
Abstract 4364473: Impact of side branch calcification on bifurcation percutaneous coronary intervention: Analysis from the PROGRESS-BIFURCATION registry
Background: The impact of side branch (SB) calcification on the outcomes of bifurcation percutaneous coronary intervention (PCI) remains understudied....
Abstract 4370879: Global Trends in Ischemic Heart Disease Mortality: A 31-Year Analysis from the Global Burden of Disease Study (1990–2021)
Introduction: Ischemic heart disease (IHD) remains the leading cause of cardiovascular-related mortality worldwide, posing a persistent global health burden. Despite advances in pr...
Abstract 4363207: Targeted IL-1 Inhibition in Coxsackievirus-Induced Incessant Pericarditis: An Immunotherapy Approach
Case Presentation: A previously healthy 33-year-old woman developed acute pericarditis with early tamponade physiology following a Coxsackievirus B infection contracted from her ch...
Abstract 4368885: Progression in Cardiovascular-Kidney-Metabolic (CKM) Stages Over 7 Years in Mid-Life: The Dallas Heart Study
Introduction: While previous studies have quantified the community prevalence of Cardiovascular-Kidney-Metabolic (CKM) Stages, limited data exist regarding the expected progression...
Abstract 4362867: Endovascular Treatment Versus Best Medical Therapy for Acute Ischemic Stroke Due to Medium or Distal Vessel Occlusions: A Meta-Analysis of Randomized Controlled Trials
Background: The role of endovascular treatment (EVT) in acute ischemic stroke due to medium or distal vessel occlusions remains uncertain, with limited randomized evidence guiding...
Abstract 4342247: Machine learning of echocardiographic left ventricular myocardial radiomics for identification of transthyretin amyloid cardiomyopathy
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an important cause of heart failure (HF) characterized by increased left ventricular (LV) wall thickness that can be c...
Abstract 4363170: Impact of Hemophilia on In-Hospital Outcomes Among Patients Undergoing Coronary Artery Bypass Graft: A Propensity-Matched Analysis of the National Inpatient Sample (2016–2022)
Introduction: Hemophilia is a rare bleeding disorder characterized by deficient clotting factors, which may increase perioperative risks in patients undergoing major cardiac surger...
Abstract 4371214: Cerebral microcirculatory disturbances after experimental cardiac arrest: arterial vasoconstriction and capillary stalling
Introduction: Cortical hypoperfusion occurs after cardiac arrest (CA). Microcirculatory disturbances have been detailed post-CA in a pediatric model, and consist of vasoconstrictio...
Abstract 4365701: Reduced Medial Prefrontal Cortex Hemodynamics and Peak Oxygen Consumption in Patients with Takotsubo Syndrome
Introduction: Preliminary data suggest that patients with takotsubo syndrome (TTS) have altered activation of stress-related brain regions. The medial prefrontal cortex (mPFC) play...
Abstract 4371610: Boosting Prediction: Machine Learning Models Outperform Traditional Risk Scores for Primary Cardiovascular Prevention
Background: Standard CVD risk calculators assume linear relationships among risk factors. ML methods (gradient boosting, random forests, neural networks, support vector machines) c...
Abstract 4358662: SVEP1 as a novel biomarker for cardiac fibrosis: Association with CT-derived extracellular volume and functional role in cardiac fibrosis
Background: Cardiac fibrosis is a key pathological form of ventricular remodeling that occurs early in heart failure. Myocardial extracellular volume fraction (ECV), measured by ca...
Abstract 4364461: Calcium-Activated Sarcomere Contractility Drives Cardiomyocyte Maturation and the Response to External Mechanical Cues But Is Dispensable for Sarcomere Formation
Understanding the mechanisms of cardiomyocyte development is critical for fulfilling the potential of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Although myocyte development is k...
Abstract 4359518: Accuracy of Angiographic Identification of Culprit Lesions in Women with MINOCA
Background: Myocardial infarction with nonobstructive coronary arteries (MINOCA) accounts for 6-15% of myocardial infarctions and disproportionately affects women. Coronary culprit...
Abstract Sat806: Racial Disparities in Bystander CPR: Is Training the Missing Link?
Background: In emergencies, every second counts. Cardiopulmonary resuscitation (CPR) can make the difference between life and death. However, recent data highlights a troubling tre...
Abstract 4366111: Neck Adiposity Measured on Pre-therapy Oncologic Computed Tomography Scans Predicts the Development of Radiation Therapy-induced Carotid Artery Disease in Patients with Head and Neck Cancer
Background: Bidirectional signaling between arteries and adjacent adipose tissue has been implicated in atherosclerosis progression. Adipose tissue characterization by CT imaging t...
Abstract 4363429: Periaortic Fat Inflammation on Preprocedural CT Predicts Long-Term Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement
Background: Chronic inflammation is a key driver of cardiovascular disease progression and may impact transcatheter aortic valve replacement (TAVR) outcomes. Higher periaortic adip...