Circulation
Articles in this Issue
Abstract WE407: Causative Association Between Longer Leukocyte Telomere Length (LTL) and Higher Risk of Atrial Fibrillation: A Meta-analysis of Mendelian Randomization Studies
Background: Atrial Fibrillation(AF) is one of the most common cardiac arrhythmias and advancing age has been associated with increased incidence of AF. Leukocyte Telomere length (L...
Abstract WE404: Trends in Survival after Atrial Fibrillation in a Midwestern Community
Background: Contemporary data on trends in survival after incident atrial fibrillation (AF) are limited. Methods:...
Abstract WE479: Serial Improvement In Left Ventricular Ejection Fraction Within the REGARDS Cohort Is Associated With Improved Mortality
Introduction: Left ventricular ejection fraction (LVEF) changes dynamically in patients with heart failure (HF), but data in racially and geographically diverse community-based coh...
Abstract TH855: Examining the Implementation of Rethink Food’s Food Is Medicine Model Leveraging Partnerships with Community-based Organizations and Restaurants
Introduction: Food insecurity affects 1.6 million New Yorkers and increases risk of cardiometabolic diseases. Traditional food assistance introduces barriers such as pantry stigma,...
Abstract TH877: A multi-state Causal Framework to Estimate the Effects of Treatment Regimes over the Course of Heart Disease
The development of chronic disease is a long-term process that involves multiple endpoints, and limited methods can assess the health benefits of a treatment regime over the disease course. Existing m...
Abstract TU197: Associations Between Individual, Psychosocial, and Neighborhood-Environment Correlates with Sedentary Time in Mexican Heritage Women: Results from the SOL CASITAS Study
Introduction: Among Hispanic/Latina women, sedentary behavior is associated with adverse cardiometabolic biomarker profiles, but little is known about which variables contribute to...
Abstract WE414: Serum Sortilin as a Predictor of Endothelial Dysfunction and Vascular Complications
Objective: This systematic review aimed to evaluate the role of serum sortilin as a reliable biomarker for vascular stenosis or calcification, with a focus on its potential to pred...
Abstract TU182: Identification of Epigenomic and Transcriptomic Markers of Coronary Artery Calcium: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Background: Coronary artery calcium (CAC) is a strong predictor of incident atherosclerotic cardiovascular disease (ASCVD) and is routinely used to clarify ASCVD risk. While differ...
Abstract TU225: Decadal Shifts in the Burden of Non-Rheumatic Valvular Heart Disease Among OECD Countries From 1990-2021: An Insight from the Global Burden of Disease Study 2021
Background: Non-Rheumatic Valvular Heart Disease (NRVHD) is the 5 th leading cause of death amongst all cardiovascular disease in organizati...
Abstract TU248: Loneliness and Days at Home Before and After Cardiovascular Disease Hospitalization: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Background: Social factors may influence older adults’ ability to recover or “bounce back” after a hospitalization for cardiovascular disease (CVD). Loneliness is a potentially mod...
Abstract WE432: Estimated optimal individualized diabetes risk prediction from preventive interventions in the US general population
Introduction: We previously developed a type 2 diabetes (T2D) risk prediction model with guideline-recommended prevention intervention effects. We lack population-level estimates o...
Abstract WE429: United States Climate Vulnerability Index and Atherosclerotic Cardiovascular Disease Risk Prediction
Introduction: Climate-amplified weather events are known to increase Atherosclerotic Cardiovascular Disease (ASCVD) risk, particularly coronary heart disease (CHD) – the most commo...
Abstract MPTH68: Proteinuria Reduction and Cardiovascular and Mortality Outcomes in Chronic Kidney Disease: Evidence Across the CKM Continuum
Introduction: Proteinuria reduction has consistently been associated with improved kidney outcomes in chronic kidney disease (CKD). However, whether reduction in proteinuria also t...
Abstract 49: Validation of Imaging-Derived Body Composition Subphenotypes Reflects Distinct Fat Distribution Patterns Associated with Different Degrees of Cardiovascular Disease Risk
Obesity affects more than one billion people and drives cardiometabolic disease risk. While traditional definitions rely on BMI, recent criteria promote direct measurement of excess adiposity, such as...
Abstract 13: Brain Proteomic Profiles Associated with Frailty and Motor Function Trajectories in Community-Dwelling Older Adults
Introduction: Motor function decline and increase in frailty accelerate with aging and are associated shorter lifespan. These functional changes have been associated with age-relat...
Abstract TH820: Effects of a Dietary Approaches to Stop Hypertension Diet on Circulating and Fecal Lactate Levels in Type 2 Diabetes: Findings from the DASH4D Randomized Clinical Trial
Introduction: Lactate is a major mitochondrial fuel source, the main precursor for gluconeogenesis, and a multifunctional signaling molecule. Elevated circulating lactate is associ...
Abstract TH837: Lifestyle Medicine Healthcare Model Strengthens Primary Care Delivery for Noncommunicable Diseases in Sri Lanka
Introduction: Sri Lanka’s healthcare system faces increasing strain from noncommunicable diseases (NCDs), which cause 81% of deaths and 77% of disability-adjusted life years, with...
Abstract 59: A Prospective Study of E-cigarette Use and Risk of Incident Hypertension in U.S. Adults
Background: Electronic cigarette (e-cigarette) has now become the second most popular tobacco product in the United States (U.S.). However, due to the relatively recent market entr...
Abstract TH826: Impact of Glucagon-Like Peptide-1 Receptor Agonists on Asthma Exacerbations Among Individuals with Type 2 Diabetes and Asthma: A Target Trial Emulation Study
Background: There is evidence that several treatments for type 2 diabetes may reduce asthma exacerbations, but prior studies had small sample sizes and short follow-ups. The object...
Abstract TH964: Trends in cardiovascular disease risk factors and predicted 10-year risk among adults with hypertension in Thailand, 2011–2018
Background: Cardiovascular disease (CVD), especially ischemic heart disease and stroke, is a leading cause of death in low- and middle-income countries (LMICs), including Thailand....
Abstract MPWE35: Postmenopausal Endogenous Sex Hormone Levels and Mild Cognitive Impairment and Dementia Risk in the Women’s Health Initiative
Introduction: Women are disproportionately likely to develop dementia, but there is an incomplete understanding of sex-specific risk factors for cognitive impairment. Whether postm...
Abstract TH917: Food Insecurity Among Older Adults with Coronary Heart Disease: 2014-2024 Trends in the United States
Introduction: The “Food is Medicine” movement calls upon medical and public health fields to recognize the role of food in chronic diseases, including heart disease. However, food...
Abstract TH825: Diabetic Ketoacidosis in Patients Treated with GLP-1 Agonists and SGLT2 Inhibitors: A Case Series and Clinical Implications in Cardiovascular Care
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) are known to have cardioprotective effects. Their use can...
Abstract TH973: Longitudinal Associations of Blood Pressure and Arterial Stiffness in Youth with Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study
Introduction: Increasing arterial stiffness and blood pressure (BP) are thought to contribute to cardiovascular disease risk in youth-onset type 1 (T1D) and type 2 (T2D) diabetes....
Abstract WE447: Rising Burden of Endocarditis in OECD Nations: Demographic Shifts and Epidemiological Insights from 1990-2021
Background: Endocarditis is associated with substantial morbidity and mortality, particularly in high-income settings. In OECD countries, its burden is exacerbated by aging populat...