Circulation
Articles in this Issue
Abstract TH971: Life’s Essential 8-Based Models Predict Subclinical Cardiovascular Disease And Are Not Strengthened by the Inclusion of Social Determinants of Health
Introduction: Life’s Essential 8 (LE8) is validated method of quantifying cardiovascular health (CVH). Although SDoH impact CVH, LE8 lacks direct SDoH measures....
Abstract 48: Echocardiogram Video Vision Foundation Model (Echo-Vision-FM): A Pre-training and Fine-tuning Framework for Automated Echocardiogram Analysis
Introduction: Echocardiography is essential for cardiac assessment, yet interpretation requires substantial expertise and suffers from inter-observer variability. Current AI approa...
Abstract TH810: PILI Aina: A Multilevel, Culturally Grounded Intervention to Improve Diet and Cardiometabolic Health in Native Hawaiian Homestead Communities
Background: Native Hawaiians (NHs), especially those living on homesteads, face disproportionate burdens of obesity, type 2 diabetes, hypertension, and dyslipidemia. Structural ine...
Abstract TH850: Explainable Digital Twins for Noninvasive Echocardiographic Reconstruction of Left Ventricular Pressure-Volume Loops
Introduction: Pressure-volume (PV) loops are central to characterizing ventricular function but typically require invasive catheterization. Apical four-chamber (4CH) echocardiograp...
Abstract TU176: Differential Impacts of Wild Blueberry Consumption on Cardiometabolic Health in Middle-Aged/Older Adults with Above-Normal Blood Pressure
Background: Evidence suggests polyphenol-rich wild blueberry (WBB) consumption can improve cardiovascular health, but research in middle-aged and older adults with above-normal blo...
Abstract TH966: Allostatic load and subclinical atherosclerosis in young adults
Introduction: Allostatic load (AL) is a composite measure of multisystem physiological dysregulation. Elevated AL has been identified as a precursor to cardiovascular and metabolic...
Abstract TH983: Endometriosis and Subsequeent Risk of Hyperlipidemia
Background: Endometriosis affects 11% of reproductive-aged women in the US. Endometriosis has been associated with increased risk of hypercholesterolemia (>240 mg/dL total chole...
Abstract 31: Association of Multiple Dimensions of Sleep with Lifespan Trajectories of Blood Pressure from Childhood through Early Adulthood
Objective: To investigate whether inadequate sleep confers long-term risk on the lifespan trajectories of blood pressure (BP) levels from childhood through adolescence into young a...
Abstract 39: Risk Factor Contributions Toward Incident Cardiovascular Disease Among Younger Adults With Short- and Long-Term Predicting Risk of Cardiovascular Disease EVENTs (PREVENT) Risk: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort
Background: The American Heart Association’s PREVENT risk equations estimate both 10-year and 30-year risks for cardiovascular disease (CVD) in younger adults aged 30–59 years. Rec...
Abstract TU277: Ironing Out Risk Using the Women’s Health Initiative Study: Low Ferritin Levels are Linked to Elevated Cardiovascular Risk in Postmenopausal Women
Background: Postmenopausal women face an elevated risk of cardiovascular disease (CVD), the leading cause of death among women. Improving the prediction of adverse cardiovascular e...
Abstract TU282: Postpartum Proteomic Networks Are Predictive of Future Cardiovascular Disease Risk in Women
Introduction: Cardiovascular disease (CVD) is the leading cause of death for US women. However, female-specific risk factors, especially pregnancy-related factors, are not included...
Abstract TU172: Sodium and Potassium in 24-h Urine among Adults: Italian Health Examination Survey 2023-2025 - CUORE Project
Introduction: One of the most cost-effective ways to reduce the burden of NCDs is the reduction of sodium intake. WHO recommends a 30% relative reduction in mean population intake...
Abstract WE495: Deprivation Index and Cardiovascular Diseases Risk Factors in the Italian Adult Population: Results from CUORE Project
Introduction: Cardiovascular diseases (CVDs) are shaped by multiple factors, including socio-economic status. Deprivation Indexes (DIs) are increasingly used to improve the stratif...
Abstract TU170: Evidence and Gap Map Summarizing the Relationship between Supplemental Potassium and CVD-related Indicators and CVD Morbidity and Mortality
Background: Potassium supplementation has emerged as a promising strategy to reduce blood pressure and cardiovascular disease (CVD) risk. However, uncertainties remain regarding op...
Abstract 68: Metabolomic Profiles of Cardiac Structure and Function and Their Associations with Incident Heart Failure in Multi-Ethnic Populations
Introduction: Metabolic dysregulation is associated with heart failure (HF). However, comprehensive evaluation of the effect of circulating metabolites on cardiac function, a criti...
Abstract TH968: Piloting Feasibility of Conducting Arterial Stiffness Measurements in the Emergency Department
Introduction: Chest pain remains one of the most common and complex presentations in the emergency department (ED), requiring rapid and accurate identification of acute coronary sy...
Abstract TH963: Performance of PREVENT-HF Risk Equations across HFpEF vs HFrEF
Background: The recent PREVENT-HF risk equations were developed to estimate 10-year risk of overall HF. While HF with preserved vs reduced ejection fraction (HFpEF; HFrEF) have com...
Abstract WE522: Association of Body Roundness Index (BRI) with Left Ventricular Systolic Function: The Framingham Heart Study
Introduction: Obesity, as assessed by body mass index (BMI), is associated with excess burden of cardiovascular disease, including heart failure, but BMI does not account for body...
Abstract TU179: Leveraging Pleiotropy to Improve Polygenic Risk Scores for Dyslipidemia Prediction
Background: Current genomic risk prediction models explain only a small fraction of lipid variability and often underperform in non-European populations. Because many lipid-associa...
Abstract TU205: The Effect of Physical Activity on the Gut Microbiome in Prediabetes: Results from a Randomized Controlled Trial
Objective: To test the effect of physical activity on the gut microbiome and circulating short chain fatty acids among sedentary overweight/obese adults with prediabetes. We hypoth...
Abstract TU193: Plasma proteomics of fatigue and risk of incident heart failure in the Atherosclerosis Risk in Communities (ARIC) Study
Background: Among individuals at risk for heart failure (HF), general and exertional fatigue are common symptoms and are associated with HF development. The biological mechanisms u...
Abstract WE506: The Association of Dairy-Related Metabolites with High Blood Pressure: The Coronary Artery Risk Development in Young Adults Study
Introduction: Hypertension is a major risk factor for cardiovascular disease. Dairy products provide nutrients that may affect blood pressure, but evidence on associations of dairy...
Abstract TU202: Pilot Data: Respiratory Exchange Ratio Predicts Perceived Exertion During Graded Maximal Exercise Testing
Introduction: Perceived exertion (RPE) and physiological indices measured during cardiopulmonary testing gauge exercise intensity. Since oxygen consumption (VO2) absent from a know...
Abstract MPTH75: Linking Pulmonary Function Decline and Cardiovascular Disease Risk via Plasma Proteomics
Background: Pulmonary function decline is associated with an increased risk of cardiovascular disease (CVD), yet the underlying molecular mechanisms remain unclear. We aimed to ide...
Abstract WE423: Intersection between Cardiovascular-Kidney-Metabolic (CKM) Syndrome and Inflammation in Incident Cardiovascular Disease (CVD) and All-cause Mortality: MESA and CARDIA
Background: Limited data exists on the longitudinal joint associations of CKM syndrome and systemic inflammation with incident CVD events....