Circulation
Articles in this Issue
Abstract TH935: Glucagon-Like Peptide-1 Receptor Agonists Are More Frequently Prescribed to Individuals at Lower Predicted Cardiovascular Risk Than Those at Higher Risk Among People Without Diabetes
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1s) are effective for weight loss. Moreover, the SELECT trial showed that semaglutide reduced cardiovascular disease (C...
Abstract TU241: Psychosocial Assets Promote Cardiovascular Health Across Adulthood: A Mixed Methods Investigation
Introduction: There is growing recognition that psychosocial factors contribute to cardiovascular outcomes. A large body of research consistently finds that risk factors like depre...
Abstract WE435: Metabolomic Signatures Linking Continuous Glucose Monitoring–Derived Fasting Glucose Variability to Increased Type 2 Diabetes Risk
Introduction: Fasting plasma glucose is a cornerstone for diagnosing prediabetes and diabetes. However, a single measurement overlooks substantial intraindividual variability, as r...
Abstract TH871: High Lipoprotein (a) Associated with Decreased Bone Mineral Density in Post-Menopausal Women
Introduction: Cardiovascular markers, including lipoprotein(a) (Lp(a)), are hypothesized to be associated with skeletal bone health because of an association between oxidative stre...
Abstract WE428: Climate-Related Exposures During Pregnancy Influence Maternal Cardiometabolic Risk: Findings from the GROWell Trial
Background: Pregnancy-related complications increase risk for long-term cardiovascular (CV) disease. Environmental exposures such as fine particulate matter (PM...
Abstract TH875: Assessing Calibration and Recalibration of Clinical Prediction Models Using Pseudo-Values Regression
Introduction: Clinical risk scores are evaluated in terms of discrimination (correctly classifying patients) and calibration (accurately predicting individualized risks). When comp...
Abstract TU262: Sleep Duration Associated with Social, Structural, and Emotional Determinants of Health
Introduction: Few studies have examined population-level sleep health relative to salient but less well-studied structural / social / emotional determinants of health....
Abstract TH932: National Trends in Oral Anticoagulant Use Among U.S. Adults and Different Subgroups: Analysis of NHANES 2009–2020
Background: Over the past decade, direct oral anticoagulants (DOACs) have increasingly replaced warfarin as the preferred agents for multiple indications, with specific agents favo...
Abstract TU110: Latent Classes of Health-Related Social Needs and Associated Cardiovascular Risk in US Older Adults: Findings from the National Health and Aging Trends Study (NHATS)
Introduction: Health related social needs (HRSN) are associated with adverse cardiovascular (CV) outcomes in the growing US older adult population. Identifying subgroups with disti...
Abstract WE471: Entrenched Geography of the United States Ischemic Heart Disease Mortality: Geotemporal Persistence and Social Determinants Through 2016-2023.
Background: Ischemic heart disease (IHD) remains the leading cause of death in the United States, with longstanding geographic disparities. The COVID-19 pandemic disrupted care del...
Abstract WE563: Loneliness, Social Support and Cardiovascular Risk Among Midlife Adults: A Population-Based Study Using the 2023 Behavioral Risk Factor Surveillance System.
Introduction: Loneliness and low social support are potential risk factors for cardiovascular disease (CVD). Both are linked to stress-related neuroendocrine and inflammatory chang...
Abstract TH975: Limited English Proficiency and its Association with Hypertension Cascade among a Nationally Representative Sample of Reproductive-aged Women
Background: Hypertension is a major risk factor for cardiovascular disease among reproductive-aged women. Language barriers may contribute to disparities in hypertension awareness,...
Abstract TU215: Associations Between Rurality and Early Pregnancy Cardiovascular Health Behaviors in a Central Appalachian Cohort
Introduction: Ideal cardiovascular health behaviors are associated with lower rates of cardiovascular and other pregnancy complications. Since such complications are more prominent...
Abstract WE466: Al Ritmo del Corazón: Regional Differences in Physical Activity and Hypertension Across Puerto Rico, Hawaii, and the Mainland United States
Introduction: Hypertension (HT) remains a leading driver of cardiovascular disease in the US, but its burden is unevenly distributed across regions. The prevalence of HT varies sig...
Abstract WE484: Mortality From Coexisting Metabolic Syndrome and Cardiac Arrhythmias Increased in the United States From 1999 to 2023
Introduction: Metabolic syndrome (MS), represented by a constellation of metabolic abnormalities is a prothrombotic and proinflammatory state, known to interrupt the electrical con...
Abstract WE463: Circulating Metabolites Mediate the Association Between Polygenic Risk Score and Incident Hypertension
Objective: Genetic susceptibility quantified by a polygenic risk score (PRS) is associated with incident hypertension, yet the metabolic pathways linking genetic risk to disease re...
Abstract 52: Long-term Diabetes Incidence Among Young Adults By Glycemic Status And Risk Scores: 35-Year Follow-Up in the Coronary Artery Risk Development In Young Adults (CARDIA) Study
Introduction: Young adulthood is increasingly recognized as an important window for diabetes prevention. While lifestyle interventions and pharmacotherapy are available to young ad...
Abstract 69: Healthy Dietary Pattern, Blood Transcriptomic Profile, and Risk of Cardiovascular Disease: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Background: A healthy diet is crucial for preventing cardiovascular disease (CVD) by modulating gene expression, but the gene pathways remain poorly studied....
Abstract MPTH77: Genome-wide Characterization of Fourteen Circulating Metals and Possible Contribution to Cardiovascular-Kidney-Metabolic Syndrome
Introduction: Trace metals, both essential and non-essential, can be toxic at abnormally high or low concentrations and may contribute to cardiovascular-kidney-metabolic (CKM) synd...
Abstract TH982: Proteomic Profiles and Pathways of Ischemic Stroke Risk in Women from the Nurses’ Health Study
Background: Ischemic stroke (IS) is a major global cause of death and disability, especially affecting women, who have a 20% higher lifetime risk and poorer recovery. Despite its p...
Abstract 60: Effect of Multivitamin Reduces Within-Visit Blood Pressure Variability in Older Adults: Findings from the COSMOS Randomized Controlled Trial
Background: Within-Visit Blood Pressure Variability (WVBPV) reflects short-term fluctuations in BP readings. Although less studied than mean blood pressure, WVBPV is an independent...
Abstract TU153: Demographic and Geographic Disparities in Ischemic Stroke Mortality with Comorbid Hypertension: A Nationwide Analysis, 2000–2020
Background: Ischemic stroke (IS) and hypertension are closely linked cardiovascular conditions, with hypertension being the most significant modifiable risk factor for the developm...
Abstract TU109: Sex Differences in Frailty Phenotypes among Older Adults with Cardiovascular Disease
Introduction: Frailty is highly prevalent and prognostically significant among older adults with cardiovascular disease (CVD). Studies have shown that women are more likely to be f...
Abstract MPTH57: Racial disparities in accelerated hypertension onset among women and the role of neighborhood disinvestment: the REasons for Geographic and Racial Differences in Stroke Study
Background: Although Black women are known to have higher hypertension rates than White women, longitudinal investigations of racial disparities in accelerated hypertension onset a...
Abstract WE550: Impact of the Mindfulness-Based Blood Pressure Reduction (MB-BP) Program on Cardiovascular Health: A Randomized Clinical Trial
Background: Mindfulness-based interventions may improve cardiovascular health (CVH) by supporting behavioral change across multiple risk factors. This study evaluated the impact of...