Circulation
Articles in this Issue
Abstract TH870: Elevated Lipoprotein(a) and Atherosclerotic Cardiovascular Disease Risk at Optimal Low-Density Lipoprotein Cholesterol Levels in Statin-Naive Adults
Introduction: Lipoprotein(a) [Lp(a)] is an established independent risk factor for atherosclerotic cardiovascular disease (ASCVD), but its impact among statin-naive individuals wit...
Abstract MPTU17: A Culturally Tailored, Fully Cost-Offset Community-Supported Agriculture (CSA) Program To Improve Food Security And Diet In New York City
Introduction: Community-supported agriculture (CSA) programs are an evidence-based approach to improve food security and diet. However, cost, accessibility, and cultural disconnect...
Abstract TH868: Plasma Lipidome, Apolipoprotein-Defined High-Density Lipoprotein Subspecies, and Their Associations with Coronary Heart Disease Risk
Introduction: HDL subspecies defined by functional apolipoproteins (apo) exhibit different associations with coronary heart disease (CHD) risk; however, the underlying mechanism, p...
Abstract TH976: Premenopausal Depression and Risk of Incident Cardiovascular Disease in Postmenopausal Women: A TriNetX-Based Cohort Study
Objective: This study aimed to determine whether depression diagnosed prior to menopause independently predicts incident cardiovascular disease (CVD) after menopause, addressing an...
Abstract 38: Objectively-Measured Individual-Level Nighttime Light Exposure Was Associated With Increased Cardiovascular Disease Risk and Adverse Cardiovascular Imaging Phenotypes
Introduction: Circadian rhythm disruption has been implicated as a risk factor for cardiovascular disease (CVD). Yet, whether light, the primary circadian entrainer, affects CVD ri...
Abstract WE417: Inflammation and Long-Term Progression of Cardiovascular-Kidney-Metabolic Syndrome Among Young Adults: Insights from the CARDIA Study
Background: Chronic, low-grade inflammation is increasingly recognized as an important mechanism underlying the development of cardiovascular, kidney, and metabolic (CKM) condition...
Abstract TH890: Urinary Metabolomics Signature for Cognitive Function among African American Patients with Chronic Kidney Disease
Introduction: Patients with chronic kidney disease (CKD) have a substantially higher risk of cognitive impairment. Metabolic dysregulation and accumulation of uremic toxins in CKD...
Abstract TU123: Indicators of Cardiovascular Risk Factors in Hispanic Children
Background: Childhood represents a critical window for the development of cardiovascular health. Early exposure to psychological stress and adverse experiences can alter autonomic,...
Abstract TH903: Health Literacy and Lifestyles in the Italian Adult Population Aged Under and Over 65 Years: a National Survey
Introduction: Health literacy (HL) refers to people’s ability to find, understand, judge, and use health information to take health-related decisions....
Abstract TU259: Increased Mean Arterial Pressure Was Prospectively Associated With a Higher 45-year Mortality Risk From Cardiovascular Disease In Men: The NHLBI Twin Study
Saam Honarvar, D.O. ’28, MPH 1 ; Craig Clark, D.O. 2 ; Jun Dai, M.D., M.Sc., Ph.D....
Abstract TH853: Performance of Machine Learning-based Weighted Life’s Essential 8 Scores in Predicting Cardiovascular and All-Cause Mortality
Background: The American Heart Association's Life's Essential 8 (LE8) metric uses equal weighting across eight components to predict CVD risk and mortality. However, there is evide...
Abstract TU240: Depression and 10-Year Cardiovascular Disease Risk in a Nationally Representative Sample using AHA PREVENT Equation
Background: Cardiovascular disease (CVD) remains the leading cause of death in the United States. In 2023, the American Heart Association (AHA) introduced the PREVENT equation to p...
Abstract WE474: Trends and Disparities in Heart Failure and Atrial Fibrillation-Related Mortality in the United States – A Nationwide Retrospective Analysis
Background: Atrial fibrillation (AF) is a significant contributor to heart failure (HF) exacerbations and associated with significant mortality and morbidity, however limited resea...
Abstract TH959: Early Metabolic Imbalance in Lean Young Adults is a Risk Factor for Midlife Obesity
Background: Early metabolic imbalance (EMI) is an overlooked condition characterized by compensatory hyperinsulinemia in the face of normal fasting glucose, triglycerides, hemoglob...
Abstract MPTU09: Gut Microbiome Mediates Diet-Driven Diabetes Risk in American Indians
Background: American Indians experience a markedly high prevalence of type 2 diabetes (T2D). Emerging evidence links the gut microbiome to T2D, yet data in this high-risk populatio...
Abstract TU204: Glucagon-like Peptide-1 Receptor Agonists: Are They Associated With Increased Cardiorespiratory Fitness?
Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1) promote weight loss, improve diabetes, and reduce cardiovascular events in obesity. While physical activity (PA) shoul...
Abstract MPTU13: Inclusion of Incarcerated Individuals and Their Families in Cardiovascular Health Research: Insights from Community-Based Focus Groups
Background: Incarceration is a structural determinant of cardiovascular disease (CVD) risk with profound health consequences for both directly impacted individuals and their famili...
Abstract TH899: Summary Measure of Social Determinants of Health/Health Equity and Cardiovascular Disease Outcomes among Mississippi Adults
Background: Cardiovascular disease (CVD) is the leading cause of death in Mississippi. Mississippi adults experiencing numerous social determinants of health/health equity (SDOH/HE...
Abstract MPTH61: Women that Meet the Muscle-strengthening Physical Activity Guideline Are Less Likely to Report Hypertension
Introduction: Approximately 43% of US women have hypertension, which can cause serious health conditions (e.g., stroke, heart attack). Previous research has shown that muscle-stren...
Abstract TH843: Signatures for Tailored Cardiovascular Communication: A Three-Pathway Classification With Chatbot-Enabled Delivery
Background: One-size-fits-all counseling often underperforms in long-term cardiovascular prevention where sustained activation is required. We developed Signatures, a practical fra...
Abstract MPWE30: Sublingual Microvascular Features and Cognition in Midlife Among Women with a History of Vascular Injury in the Placenta
Objective: Women with preeclampsia (PE) or placental evidence of maternal vascular malperfusion (MVM) have excess risk for cardiovascular and cerebrovascular disease years after de...
Abstract TH929: GLP-1 Receptor Agonist Medication Use Persistence in the All of Us Research Program
Introduction: Real-world data reveal long-term persistence with GLP-1 Receptor Agonists (RAs) is low. This study examines GLP-1 RA prescription trends and the association between s...
Abstract WE437: Prevalence and Determinants of Diabetes Mellitus in a Semi-Urban Nigerian Riverine Community: Implications for Intervention in Resource-Limited Settings
Background: Diabetes mellitus is a leading global cause of cardiovascular morbidity and mortality, with a rising burden in low- and middle-income countries. Although its prevalence...
Abstract TU191: Urinary sodium and potassium excretions, gut microbiome, circulating metabolites, and cardiometabolic risk
Background: A high-sodium, low-potassium diet promotes hypertension and cardiovascular disease (CVD). Intricate interactions between the gut microbiota and minerals, encompassing a...
Abstract WE427: Percent Black Residents Modifies the Association between Neighborhood Private Well Use and CVD Mortality
Introduction: More magnesium in drinking water is associated with lower CVD risk, while more lead is associated with higher CVD risk. Rural US residents often rely on private well...