Circulation
Articles in this Issue
Abstract TU252: Hospital-level Disparities and Long-term Survival in Patients With STEMI: Evidence from the China Acute Myocardial Infarction Registry
Objective: We aimed to examine the association between hospital level and 5-year mortality among ST-segment elevation myocardial infarction (STEMI) patients in China, and identify...
Abstract MPTH73: Gut microbiome, blood metabolome and incident hypertension in Hispanic Community Health Study/Study of Latinos
Background: While gut dysbiosis is linked to prevalent hypertension (HTN), microbial features associated with incident HTN and the mediating role of circulating metabolites remain...
Abstract TU219: Impact of Adverse Pregnancy Outcomes on Long-term Outcomes in Women with Heart Failure
Introduction: Adverse pregnancy outcomes (APOs) are risk factors for future cardiovascular disease, including heart failure (HF). However, the impact of a history of APOs among wom...
Abstract MPTU10: Metformin Use, Gene Expression, and Cardiometabolic Health in People with Diabetes: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Background: Metformin may offer anti-aging and cardiometabolic benefits beyond its typical role in glycemic control through regulating gene expression, but its relationship with wh...
Abstract WE468: Axillary/Subclavian IABP Is a Safe and Effective Support in Advanced Heart Failure: A Meta-Analysis
Background: Axillary intra-aortic balloon pumps (IABPs) represent an emerging approach to support patients with advanced heart failure, particularly those awaiting heart transplant...
Abstract TU213: Human Milk Consumption During the Neonatal Hospitalization is Not Associated with Length- or Weight-for-Age at Discharge for Infants with Critical Congenital Heart Disease.
Introduction: Human milk is the optimal nutritional source for infants. In critically ill infants, human milk offers benefits related to disease reduction (eg, lower necrotizing en...
Abstract MPTU04: Sex- and Disease-Stratified Performance of Federated Learning for Multi-Label Cardiovascular Disease Detection: A Real-World ECG Analysis
Background: Federated learning (FL) enables privacy-preserving collaborative model training across healthcare institutions without sharing patient data. We evaluated disease-specif...
Abstract 65: Food Insecurity Modifies Effect of GoFresh DASH-Patterned Grocery Intervention on Blood Pressure in Black Adults with High Blood Pressure
Introduction: While the DASH diet improves blood pressure (BP) in tightly controlled research studies, health-related social needs such as food insecurity may limit its implementat...
Abstract WE552: Differences in metabolic, behavioural and psychosocial risk factors and mortality in women and men: nationwide population based cohort study
Background: Little is known about the interaction and joint associations of sex and modifiable risk factors with mortality, leaving critical gaps in understanding their contributio...
Abstract TH842: Machine Learning–Based Analysis of Behavioral and Social Determinants of Cardiovascular Mortality in Adults With Diabetes
Introduction: Cardiovascular (CV) mortality remains high among adults with diabetes. The impact of behavioral and social factors contributing to this heightened risk is not well un...
Abstract TU140: Predictors of Smokeless Tobacco and Paan Initiation During the School-to-Work Transition Among Indian Adolescents: A Prospective Cohort Study
Introduction: Tobacco initiation during adolescence remains a critical contributor to India’s cardiovascular and oral-disease burden. With early initiation often occurring between...
Abstract TU180: Pleiotropic and eQTL Analysis of Lipid Traits Identifies Novel Genetic Signals in African-Ancestry Populations
Background: Dyslipidemia is a major, modifiable determinant of cardiovascular disease (CVD). However, the genetic architecture of lipid regulation remains incompletely understood,...
Abstract 58: Clinical and Biomarker Subtypes of Preeclampsia and Future Cardiovascular Health
Background: Preeclampsia is a leading cause of maternal-fetal morbidity and strongly linked to future cardiovascular disease. Prediction and prevention remain limited, in part due...
Abstract TU166: Food Insecurity, Food Assistance, and Cardiovascular Disease Risk Factors Among U.S. Adults
Background: Food insecurity (FI) is defined as limited or uncertain access to adequate food and remains a critical public health concern in the US. National rates of FI have contin...
Abstract TH847: Explainable Machine Learning–Identified Protective Social, Behavioral, and Clinical Factors for Cardiovascular Diseases
Background: Cardiovascular diseases (CVDs) remain the leading cause of death globally, yet traditional risk tools underweight protective social and behavioral contexts that shape c...
Abstract TH818: Associations of Glycemic Control and Diabetes Duration With Incident Dementia: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
Introduction: Diabetes, a modifiable risk factor for dementia, is thought to impart increased risk of dementia through cerebral small vessel disease. While the importance of diabet...
Abstract TU113: Implementing a Community-based Cardiovascular-Kidney-Metabolic Health Program: An FQHC&AMC Partnership
The community of Mattapan (Boston, MA, USA) holds one of the city’s highest rates of CVD-related mortality and shortened life expectancy with disproportionate incidence of cardiovascular kidney metabo...
Abstract WE482: Age- and Sex-Specific Incidence of Cardiovascular Disease Subtypes in Young Adults: Insights from a Large, Diverse Healthcare System
Background: Cardiovascular disease (CVD) is increasingly recognized among younger adults, yet age-, sex-, and race/ethnicity-specific incidence patterns across subtypes remain unde...
Abstract TU108: Orthostatic Blood Pressure Phenotypes are Associated with Night-Time Blood Pressure Non-Dipping in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study
Introduction: Nighttime blood pressure (BP) non-dipping (i.e., a blunted reduction in BP during sleep) is associated with higher risk of cardiovascular disease, stroke, cognitive d...
Abstract WE532: Association of Daily Step Count with All-Cause Mortality Among Older Adults with Hypertension and Resistant Hypertension
Introduction: Physical activity, particularly daily step count, is associated with all-cause mortality in older adults. However, evidence is limited among those with hypertension a...
Abstract 45: Age-Standardized Prevalence of Cardiometabolic Risk Factors Across African Regions: A Pooled Analysis of Population-Based Surveys from 18 Countries.
Background: Noncommunicable diseases are rising across Africa, yet regional profiles of key cardiometabolic risk factors remain incompletely characterized. We compared age-standard...
Abstract TH936: Cardiovascular Health as Defined by Life’s Essential 8 is Associated with Vascular Function in Middle-Aged Females
Introduction: The American Heart Association defines cardiovascular health as a composite measure of four health behaviors (diet, physical activity, nicotine exposure, sleep health...
Abstract 11: Early-Life Famine Exposure and Adult Transitions Across Cardiovascular-Kidney-Metabolic Health Stages: A Prospective Cohort Study in China
Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome represents a progressive pathophysiological continuum. While early-life famine exposure has been associated with cardio...
Abstract WE520: When Metabolism Breaks the Heart: Global Meta-analysis Linking Metabolic Syndrome to Heart Failure (≈5 Million Participants)
Background: Metabolic syndrome (MetS) accelerates cardiovascular remodeling through insulin resistance, adipose driven inflammation and neurohormonal activation, yet its contempora...
Abstract 43: Evolving Spectrum and Short-Term Outcomes of Infective Endocarditis in North India And Comparison Between Intravenous Drug Users and Non-Users
Background: Patterns of infective endocarditis (IE) are changing in developed nations, with increasing cases linked to intravenous drug use. It remains uncertain whether similar tr...