2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Abstract
AIM The “2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome” retires, replaces, and expands upon the “2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults.” The primary intended audience for this guideline is clinicians who care for patients across the spectrum of cardiovascular-kidney-metabolic syndrome, an interrelated condition characterized by the interconnections among metabolic risk factors (including obesity and type 2 diabetes), chronic kidney disease, and cardiovascular disease. METHODS A comprehensive literature search was conducted from October 29, 2024, to April 14, 2025, to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human subjects that were published since 2015 in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE The focus of this clinical practice guideline is to create a living, working document that provides current knowledge in the field of cardiovascular-kidney-metabolic syndrome aimed at all practicing cardiologists, endocrinologists, nephrologists, and primary care and specialty clinicians who manage these patients.
Article Details
Authors (61)
Chiadi E. Ndumele
Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore
Fatima Rodriguez
Dave L. Dixon
ACC/AHA Joint Committee on Clinical Practice Guidelines liaison.
Sadiya S. Khan
Debabrata Mukherjee
Department of Chemical Sciences Indian Institute of Science Education and Research Kolkata Mohanpur Nadia 741246 India
Mandeep Bajaj
ADA representative.
Sripal Bangalore
Biykem Bozkurt
Winters Center for Heart Failure Research, Cardiovascular Research Institute, Baylor College of Medicine, Houston
Khadijah Breathett
Shoa L. Clarke
Ian H. de Boer
ASN representative.
David H. Ellison
Lorraine S. Evangelista
Sean P. Heffron
Dhruv S. Kazi
Ambar Kulshreshtha
Ildiko Lingvay
Department of Internal Medicine and Endocrinology, University of Texas Southwestern Medical Center, Dallas
Cecilia C. Low Wang
Claudia A. Mercado
Patient advocate representative.
John Magaña Morton
Ian J. Neeland
Neha Pagidipati
Tiffany M. Powell-Wiley
Janani Rangaswami
George Washington University School of Medicine, Washington DC Veterans Affairs Medical Center, Washington, DC (J.R.).
Goutham Rao
Nosheen Reza
Anum Saeed
Wendy St. Peter
J. Bradley Starks
Patient advocate representative.
Madeline Sterling
Amy W. Talbot
Former AHA/ACC joint staff; current staff member during the writing effort.
Andrew H. Tran
Katherine R. Tuttle
Providence Inland Northwest Health, University of Washington School of Medicine, Spokane
Lisa B. VanWagner
Amanda R. Vest
Salim S. Virani
Nicole Bhave
Amit Khera
Kevin M. Alexander
Alison L. Bailey
Marc P. Bonaca
Tara I. Chang
Cyrille K. Cornelio
Maria Rosa Costanzo
Colette DeJong
Adam DeVore
Patrick O. Gee
Beverly B. Green
Jennifer B. Green
Scott Kahan
Anuradha Lala
Melissa Magwire
Michael Miller
Katie Moegenberg
Elif Oral
Carl E. Orringer
Kershaw V. Patel
Sonali Patel
Jane E.B. Reusch
Philip Schauer
Daniel E. Weiner