Journal of Biological Chemistry

Scalable purification enables high-quality virus-like particles for therapeutic translation

Rafal Hołubowicz, Fangyuan Gao, Samuel W. Du et al. Dec 01, 2025 pp. 110946 10.1016/j.jbc.2025.110946

Jade1 and the HBO1 histone acetyltransferase complex are spatial-selective cofactors of the pluripotency transcription factor Oct4

Yifan Wu, Asit K. Manna, Li Li et al. Dec 01, 2025 pp. 110859 10.1016/j.jbc.2025.110859

Long non-coding RNA enhances SARS-CoV-2-mediated apoptosis through epigenetic repression of angiotensin-converting enzyme 2

Weijie Liao, Tian Zhang, Jiaxing Cao et al. Dec 01, 2025 pp. 110812 10.1016/j.jbc.2025.110812

Non-catalytic UBL2 domain directs deubiquitinase USP11 toward K48-linked polyubiquitin chains

Sin-Rong Lee, Han-Hsiun Chen, Ruey-Hwa Chen et al. Dec 01, 2025 pp. 110924 10.1016/j.jbc.2025.110924

Phylogenetic and biochemical analysis of the evolution and interdomain modularity of bifunctional L-fucokinase/GDP-fucose pyrophosphorylases

Nicholas T. Smith, Autumn J. Hodgins, Marie E. Boddington et al. Dec 01, 2025 pp. 110937 10.1016/j.jbc.2025.110937

Type II polyketide synthases: Impact on human health, current knowledge, and future directions

Jacob T. Wolff, Shiou-Chuan Tsai Dec 01, 2025 pp. 110749 10.1016/j.jbc.2025.110749

Thermodynamics and selection of the plasminogen activator inhibitor-1 latency transition

Laura M. Haynes, Matthew L. Holding, Jaie Woodard et al. Dec 01, 2025 pp. 110896 10.1016/j.jbc.2025.110896

Structural and spectroscopic resolution of the NADPH redox state in the STEAP2 cytosolic oxidoreductase domain

Inchul Shin, Lu-Zhe Sun, Aimin Liu Dec 01, 2025 pp. 110822 10.1016/j.jbc.2025.110822

The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing, and irreversibility of the G1/S transition

Ayaka Nagasato-Ichikawa, Ken Murakami, Kazuhiro Aoki et al. Dec 01, 2025 pp. 110865 10.1016/j.jbc.2025.110865

RhoE downregulation leads to enhanced cholesterol biosynthesis and sorafenib resistance in hepatocellular carcinoma

Jingxiu Feng, Ling Ye, Changyuan Chen et al. Dec 01, 2025 pp. 110918 10.1016/j.jbc.2025.110918

Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure

Kyriakos N. Papanicolaou, Wenxi Zhang, Aidan J. Dunphy et al. Dec 01, 2025 pp. 110818 10.1016/j.jbc.2025.110818

Allosteric regulation of prostaglandin endoperoxide H2 synthases

Liang Dong, Michael G. Malkowski Dec 01, 2025 pp. 110927 10.1016/j.jbc.2025.110927

Chemical and biological characterization of glycidamide-adducted adenine in DNA

Jun-ichi Akagi, Ryota Yamaguchi, Yumi Miyake et al. Dec 01, 2025 pp. 110898 10.1016/j.jbc.2025.110898

A homology-based 3D model and structure–function studies reveal key elements for divalent metal ion transporter ZIP8 (SLC39A8) function

Sven P. Baumann, Gergely Gyimesi, Giuseppe Albano et al. Dec 01, 2025 pp. 110930 10.1016/j.jbc.2025.110930

MYBPC3 N-terminal missense mutations linked to hypertrophic cardiomyopathy strengthen actin binding and enhance residue mobility

Rhye-Samuel Kanassatega, Thomas A. Bunch, Fiona L. Wong et al. Dec 01, 2025 pp. 110855 10.1016/j.jbc.2025.110855

Modulation of host functions by bacterial serine/threonine protein kinase effector proteins

Jinli Ge, Jiazhang Qiu Dec 01, 2025 pp. 110950 10.1016/j.jbc.2025.110950

MARCH8-mediated ubiquitination regulates expression of the antiviral protein IFITM3

Liang Wei, Fei Zhao, Xiaoman Liu et al. Dec 01, 2025 pp. 110879 10.1016/j.jbc.2025.110879

Histone deacetylase HDA-5 regulates lipid metabolism through H4K5 and H4K8 acetylation in Caenorhabditis elegans

Qin-Yi Wu, Meng Zhou, Rui Zhu et al. Dec 01, 2025 pp. 110893 10.1016/j.jbc.2025.110893

Transcriptome and chromatin accessibility divergence during differentiation of a bipotential progenitor cell population to erythroblasts and megakaryocytes

Tejaswini Mishra, Belinda M. Giardine, Christapher S. Morrissey et al. Dec 01, 2025 pp. 110819 10.1016/j.jbc.2025.110819

Pre-N and C-terminal extension regions of Arabidopsis HSP90.7 regulate the chaperone activity and ER stress response

Jenan Noureddine, Adheip Monikantan Nair, Kenneth Andrei Espinosa et al. Dec 01, 2025 pp. 110806 10.1016/j.jbc.2025.110806

Sirtuin 6 is a histone delactylase

Garrison A. Nickel, Nicholas J. Pederson, Faheem et al. Dec 01, 2025 pp. 110795 10.1016/j.jbc.2025.110795

Decoding ultrasensitive self-assembly of the calcium-regulated Tetrahymena cytoskeletal protein Tcb2 using optical actuation

Nithesh P. Chandrasekharan, Xiangting Lei, Jerry Honts et al. Dec 01, 2025 pp. 110824 10.1016/j.jbc.2025.110824

A S180F substitution in D-alanine aminotransferase confers resistance to β-chloro-D-alanine in Staphylococcus aureus

Rakesh Roy, Yahani P. Jayasinghe, Sasmita Panda et al. Dec 01, 2025 pp. 110931 10.1016/j.jbc.2025.110931

Dihydroxyacetone decreases the dATP pool, inducing replication stress and genomic instability in BEAS-2B cells

Saddam Hussain, Nayonika Mukherjee, Natalie R. Gassman Dec 01, 2025 pp. 110876 10.1016/j.jbc.2025.110876

Nitric oxide attenuates PI4P accumulation at the ER membrane to inhibit encephalomyocarditis virus replication selectively in β-cells

Alyssa L. Gehant, Joshua D. Stafford, Polly A. Hansen et al. Dec 01, 2025 pp. 110798 10.1016/j.jbc.2025.110798