Journal of Biological Chemistry

Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discovery

Jessica W. Wu, Katherine Titterton, Rebecca Sebastian et al. Dec 01, 2025 pp. 110853 10.1016/j.jbc.2025.110853

Expanding fluorescent base analogue labelling of long RNA by in vitro transcription

Pauline Pfeiffer, Alma F.E. Karlsson, Jesper R. Nilsson et al. Dec 01, 2025 pp. 110825 10.1016/j.jbc.2025.110825

A new amidohydrolase and β-oxidation–like pathway for piperine catabolism in soil actinomycetes

Pu Jian, Takuto Kumano, Mio Kimura et al. Dec 01, 2025 pp. 110908 10.1016/j.jbc.2025.110908

Detection of PIP2 distributions in biological membranes using a peptide-based sensor

Vinay K. Menon, Joy Wu, Alex J. Alonzo et al. Dec 01, 2025 pp. 110826 10.1016/j.jbc.2025.110826

Hsp90 co-chaperone FKBP4 facilitates CCT8 folding and connects Hsp90 to chaperonin-dependent proteostasis

Yun-Yu Huang, Ya-Lan Chang, Yun Chen et al. Dec 01, 2025 pp. 110914 10.1016/j.jbc.2025.110914

Mutagenesis of the PALB2 WD40 domain identifies variants defective in interaction with BRCA2 and DNA repair

Thiago T. Gomes, Anna Beatriz R. Elias, Huaizhi Huang et al. Dec 01, 2025 pp. 110835 10.1016/j.jbc.2025.110835

Cellular and functional insights into FIH-mediated hydroxylation of TRPA1

Tao Guo, Dianne Marquez Lopez, Siyuan Wang et al. Dec 01, 2025 pp. 110882 10.1016/j.jbc.2025.110882

Csk-dependent and -independent control of Src family kinases directs neuronal migration in the developing cerebral cortex

Yoshiaki V. Nishimura, Shiho Ito, Takeshi Kawauchi Dec 01, 2025 pp. 110877 10.1016/j.jbc.2025.110877

Tetramerization of the DNA mismatch repair protein MutS enhances daughter strand incision preferentially in the vicinity of replication errors

Yannicka Mardenborough, Romano M. van Genderen, Charlie Laffeber et al. Dec 01, 2025 pp. 110881 10.1016/j.jbc.2025.110881

Structural basis for E3 ubiquitin ligase UHRF1 binding to nucleosome core particle and histone H3 ubiquitination

Reia Shikimachi, Shun Matsuzawa, Hiroki Onoda et al. Dec 01, 2025 pp. 110894 10.1016/j.jbc.2025.110894

N-terminal half of MED14 is critical for Mediator-RNA polymerase II interaction and the resulting transcription

Yasemin Baris, Javaid Jabbar, Yasemin Yozgat et al. Dec 01, 2025 pp. 110837 10.1016/j.jbc.2025.110837

A modular Uba1-nanobody fusion enables selective ubiquitin transfer to tagged E2 enzymes

Charlotte Wijne, Francesca D'Amico, David A. Pérez Berrocal et al. Dec 01, 2025 pp. 110910 10.1016/j.jbc.2025.110910

Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress

Shun Enomoto, Yun Ha Hur, Tatiana Solodova et al. Dec 01, 2025 pp. 110821 10.1016/j.jbc.2025.110821

Mammalian and bacterial adaptors function as co-disinhibitory pairs to activate the E3 ubiquitin ligase WWP2

Samkeliso V. Blundell, Mei Liu, Romina Tocci et al. Dec 01, 2025 pp. 110847 10.1016/j.jbc.2025.110847

Extravesicular chloride ion regulates the uptake of ATP, sulfate, and inorganic phosphate by membrane vesicles from bovine adrenal chromaffin granules

Yoshinori Moriyama, Seiji Nomura, Sawako Moriyama et al. Dec 01, 2025 pp. 110892 10.1016/j.jbc.2025.110892

Mutational landscape of the G-quadruplex DNA in cMyc proto-oncogene promoter: Insights into the structural polymorphism and transcriptional regulation

Ai-Min Su, Qiu-Ying Chen, Xue-Yang Yu et al. Dec 01, 2025 pp. 110897 10.1016/j.jbc.2025.110897

A systematic comparison of in-house prepared transfection reagents in the delivery of mRNA or DNA to a wide range of cultured cells

Ravi Ojha, Emilia Timin, Leonora Szirovicza et al. Dec 01, 2025 pp. 110742 10.1016/j.jbc.2025.110742

Rewiring PTH receptor signaling: Hormone dimerization restores endosomal signaling lost in hypocalcemia-linked PTH mutant

Jonathan Pacheco, Satyaki Saha, Ji Young Lee et al. Dec 01, 2025 pp. 110913 10.1016/j.jbc.2025.110913

Optimized conditions for GTP loading of Ras

Kimberly J. Vish, Maxum E. Paul, Asha P. Rollins et al. Dec 01, 2025 pp. 110923 10.1016/j.jbc.2025.110923

Transcriptomic plasticity of cholinergic adipose macrophages in the acute thermogenic response

Alexander J. Knights, Evan J. Kim, Shanshan Liu et al. Dec 01, 2025 pp. 110925 10.1016/j.jbc.2025.110925

Seeding biosensor cell line that reproduces the Alzheimer tau fold

Taxiarchis Katsinelos, Sofia Lövestam, Chao Qi et al. Dec 01, 2025 pp. 110952 10.1016/j.jbc.2025.110952

Distal tip cell migration mutants of Caenorhabditis elegans are rescued by bioequivalent outputs from chondroitin and N-glycosylation pathways

James W. Dennis, Robert J. Dunn, Naomi Levy-Strumpf et al. Dec 01, 2025 pp. 110895 10.1016/j.jbc.2025.110895

Simple in vitro single-stranded linear and circular DNA preparation, functional selection, and validation using phosphor-derived modifications

Seyed Vahid Hamidi, Vanessa Aguilar-Sánchez, Vincent L. Héroux et al. Dec 01, 2025 pp. 110874 10.1016/j.jbc.2025.110874

Cyanophycinase is required for heterotrophy in cyanobacteria

Éva Kiss, Martin Moos, Jan Mareš et al. Dec 01, 2025 pp. 110791 10.1016/j.jbc.2025.110791

The Pseudomonas aeruginosa membrane histidine kinase BqsS/CarS directly senses environmental ferrous iron (Fe2+)

Alexander Paredes, Chioma Iheacho, Kelly N. Chacón et al. Dec 01, 2025 pp. 110801 10.1016/j.jbc.2025.110801