Journal of Biological Chemistry

The ubiquitin ligase LONRF2 inhibits glycolysis and malignant phenotypes in endometrial cancer through aldolase A degradation

Juan Shao, Cui Jiang, Yingchun Duan et al. Jul 01, 2026 pp. 113325 10.1016/j.jbc.2026.113325

Deletion of a YEDL sequence in SLC35D3 perturbs its targeting to platelet dense granule precursors

Chentong Wang, Yuanying Chen, Wenyan Zhang et al. Jul 01, 2026 pp. 113335 10.1016/j.jbc.2026.113335

The Src family kinase YES regulates DNAJB6b chaperone activity to modulate tau aggregation in Alzheimer’s disease

Meng-Chieh Lin, Huan-Yun Chen, Te-Sheng Lin et al. Jul 01, 2026 pp. 113363 10.1016/j.jbc.2026.113363

Does SLC17A9 (VNUT) function as a stand-alone nucleotide and/or phosphate transporter?

Jennifer Struck, Vivek Malviya, Marcelo Ganzella et al. Jul 01, 2026 pp. 113360 10.1016/j.jbc.2026.113360

Cryo-EM structure of the complex between transglutaminase 2 and the 45 kDa domain of fibronectin

Julie Elisabeth Heggelund, Ahmad Ali-Ahmad, Marie Kongshaug Johannesen et al. Jul 01, 2026 pp. 113326 10.1016/j.jbc.2026.113326

A covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2

Jon B. Patteson, Ioannis Manolaridis, Mee Ra Hong et al. Jul 01, 2026 pp. 113322 10.1016/j.jbc.2026.113322

Proton pump rhodopsins for optogenetic manipulation of biological activities and beyond

Keiichi Kojima, Miyu Inokuchi, Yuki Sudo Jul 01, 2026 pp. 113318 10.1016/j.jbc.2026.113318

A novel sorting method uncovers metabolic heterogeneity between mononucleated and binucleated tetraploid hepatocytes

Yusuke V. Watanabe, Jonathan H. Sussman, Tomoya Anami et al. Jul 01, 2026 pp. 113324 10.1016/j.jbc.2026.113324

Structure Determination Reveals the Mechanistic Basis of Mannose-6-P Signal Generation by the Dimeric Lysosomal Uncovering Enzyme NAGPA

Farha Khan, Chang Sun, Riley Marcinczyk et al. Jul 01, 2026 pp. 113329 10.1016/j.jbc.2026.113329

Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo

Niranjana Natarajan, Thaybah Ahmed, Balaji Govindaswamy et al. Jul 01, 2026 pp. 113315 10.1016/j.jbc.2026.113315

Sirtuin 5 knockdown induced the ferroptosis of hepatic stellate cells in hepatic fibrosis progression through de-succinylation modification of GPX4

Jun Zhou, Jinjuan Zhang, Shan Zheng et al. Jul 01, 2026 pp. 113366 10.1016/j.jbc.2026.113366

Public Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk Factors

Jake N. Hermanson, Andrew D. Hudson, Lars Plate Jul 01, 2026 pp. 113344 10.1016/j.jbc.2026.113344

Substrate and target selectivity of 4′-fluoroadenosine against viral and host polymerases

Simon M. Walker, Arlo J. Loutan, Egor P. Tchesnokov et al. Jul 01, 2026 pp. 113316 10.1016/j.jbc.2026.113316

Distinct functional roles of the GRIP domains in α-, β-, γ- and δ-ENaC

Alexandr V. Ilyaskin, Alicia Kißler, Franziska Schreiber et al. Jul 01, 2026 pp. 113336 10.1016/j.jbc.2026.113336

β-arrestin and myosin VI cooperatively control glucose-dependent insulinotropic peptide receptor (GIPR) internalization and signaling dynamics

Nishaben M. Patel, Sivaraj Sivaramakrishnan Jul 01, 2026 pp. 113339 10.1016/j.jbc.2026.113339

Structure-based functionality of a multi-domain periplasmic chitodextrinase from marine bacterium Vibrio cholerae

Kanokbhorn Khumnonkhro, Thitipat Chongrungreang, Shohei Sakuda et al. Jul 01, 2026 pp. 113351 10.1016/j.jbc.2026.113351

Decoding of amidated aromatic C-terminus and sulfation by cholecystokinin receptors reveals conserved and divergent evolutionary mechanisms

Jian-Hui Chang, Shao-Qian Wu, Xue-Ying Ding et al. Jul 01, 2026 pp. 113327 10.1016/j.jbc.2026.113327

MOF promotes venous thromboembolism in lung cancer by activating the YBX1–MALT1–NF-κB–PAI-1 axis, possibly through histone crotonylation

Yan Liu, Feng Yu, Jiuyang Jiang Jul 01, 2026 pp. 113348 10.1016/j.jbc.2026.113348

Structural characterization of intermediates in Sec1/Munc18 protein-catalyzed SNARE assembly

Abigail E. Stanton, Isabella Midura, Nanako Shirai et al. Jul 01, 2026 pp. 113352 10.1016/j.jbc.2026.113352

Alternative Extracellular Disulfide Bond Formation by N-terminal Cysteines Supports Functional Expression of Odorant Receptors

Nonoko Muto, Tomoyo Koshizawa, Miki Takeda et al. Jul 01, 2026 pp. 113319 10.1016/j.jbc.2026.113319

Molecular and Structural Dissection of Psalmopoeus pulcher Venom Reveals Cysteine-Rich Peptides that Target Acid-Sensing Ion Channel 1a

Zhaotun Hu, Jiatian Quan, Jiamin Yu et al. Jul 01, 2026 pp. 113347 10.1016/j.jbc.2026.113347

Sphingomyelin synthase 2 regulates host protection conferred by the administration of Cryptococcus neoformans Δsgl1 strain

Neelu Singh, Tyler G. Normile, Deveney Dasilva et al. Jul 01, 2026 pp. 113330 10.1016/j.jbc.2026.113330

Characterization of the splicing isoform TuSp1-sv provides novel insights into spidroin functional diversification

Xue Li, Haoxuan Xu, Jing Ge et al. Jul 01, 2026 pp. 113361 10.1016/j.jbc.2026.113361

Cyclic GMP-dependent activation of Ca2+ release from the ER and digestive vacuole at distinct phases of intraerythrocytic Plasmodium falciparum development

Maneesh K. Singh, Rute I. Honorio, Paula J. Bartlett et al. Jul 01, 2026 pp. 113346 10.1016/j.jbc.2026.113346

TGF-β2 drives lipid droplet accumulation in chondrocytes through the TβRI/p-Smad3/Fabp5 axis

Jieya Wei, Caixia Pi, Yu Qi et al. Jul 01, 2026 pp. 113317 10.1016/j.jbc.2026.113317