Journal of Biological Chemistry

Gonadotropin-releasing hormone regulates transcription of the inhibin B co-receptor, TGFBR3L, via early growth response one

Yeu-Farn Lin, Evan R.S. Buddle, Hailey Schultz et al. Sep 01, 2025 pp. 110505 10.1016/j.jbc.2025.110505

Identification and characterization of nanobodies specific for the human ubiquitin–like ISG15 protein

Jin Gan, Prachi Dabhade, Charlotte Wijne et al. Sep 01, 2025 pp. 110564 10.1016/j.jbc.2025.110564

Gut microbiota–derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase

Jessica H. Han, Federico E. Rey, John M. Denu Sep 01, 2025 pp. 110521 10.1016/j.jbc.2025.110521

Repeated activation of Gαq has a detrimental impact on C. elegans in an age-dependent manner

Madison Rennie, Suzanne Scarlata Sep 01, 2025 pp. 110518 10.1016/j.jbc.2025.110518

Polyserine–tau interactions modulate tau fibrillization

James Pratt, Kathleen McCann, Jeff Kuo et al. Sep 01, 2025 pp. 110523 10.1016/j.jbc.2025.110523

WTAP-mediated m6A methylation of circRNA_404908 promotes esophageal squamous cell carcinoma progression

Yingjie Pan, Hang Yang, Jiayi Zhang et al. Sep 01, 2025 pp. 110512 10.1016/j.jbc.2025.110512

A three-stage assembly program governing pancreatic, plasma, pituitary, and bone secretory cell differentiation: A strategy to augment protein delivery

Joseph P. Bidwell, Alexander G. Robling, Ronald C. Wek Sep 01, 2025 pp. 110562 10.1016/j.jbc.2025.110562

Negatively charged α-synuclein condensate modulates partitioning of molecules

Qingqing Yang, Shunfa Chen, Pengfei Zhang et al. Sep 01, 2025 pp. 110530 10.1016/j.jbc.2025.110530

TORC2 and MAPK signaling pathways regulate mitochondrial degradation induced by iron starvation in Schizosaccharomyces pombe

Rong Li, Jinjie Shang, Ying Huang Sep 01, 2025 pp. 110524 10.1016/j.jbc.2025.110524

Real-time monitoring of secretory protein traffic for investigating trafficking regulators of ACE2 in living cells

Chang Zhang, Mengxin Yang, Yanzun An et al. Sep 01, 2025 pp. 110593 10.1016/j.jbc.2025.110593

Neddylation inhibitor MLN4924 enhances H3K18 lactylation via binding to LDH and downregulates ITGB4 to block metastasis

Hongfei Yu, Qiyin Zhou, Yongxia Chen et al. Sep 01, 2025 pp. 110575 10.1016/j.jbc.2025.110575

Metabolomics analysis of SNAT2-deficient cells: Implications for the discovery of selective small-molecule inhibitors of an amino acid transporter

Jessica C. Koe, Yuxi C. Zhong, Kiana Pashaoskooie et al. Sep 01, 2025 pp. 110525 10.1016/j.jbc.2025.110525

Proteome solubility is differentially reshaped by thermal stress and regulators of ubiquitination

Liam C. Hunt, Anna Stephan, Suresh Poudel et al. Sep 01, 2025 pp. 110517 10.1016/j.jbc.2025.110517

The ribonucleoprotein hnRNP K promotes hepatic steatosis by suppressing the nuclear hormone receptor PPARα

Minglong Zhang, Xianghong Xie, Enhui Chen et al. Sep 01, 2025 pp. 110500 10.1016/j.jbc.2025.110500

ERK signaling promotes IKKε expression and oncogenic functions in pancreatic cancer cells in association with TBK1

Adam Graves, Angana Mukherjee, Runying Yang et al. Sep 01, 2025 pp. 110535 10.1016/j.jbc.2025.110535

DHX9 phosphorylation at S321 by ATM regulates DHX9 retention at DNA double-strand break sites and interaction with BRCA1

Saaya Matsuya, Yuina Tsuchiya, Yudai Hiwatashi et al. Sep 01, 2025 pp. 110526 10.1016/j.jbc.2025.110526

Kinetic mechanism of ENPP1 ATPase: Implications for aberrant calcification disorders and enzyme replacement therapy

Marisa M. Michalchik, Tony Potchernikov, Ethan R. Lester et al. Sep 01, 2025 pp. 110558 10.1016/j.jbc.2025.110558

Structural unification of diverse transmembrane acyltransferases reveals a conserved fold for the transmembrane acyl transferase (TmAT) superfamily

Bethan E. Kinniment-Williams, Vytaute Jurgeleviciute, Daniel T. West et al. Sep 01, 2025 pp. 110546 10.1016/j.jbc.2025.110546

A novel protein encoded by circTUBGCP3 blocks ferroptosis and promotes gastric cancer progression

Shanshan Chang, Xianli Fu, Longquan Xiang et al. Sep 01, 2025 pp. 110507 10.1016/j.jbc.2025.110507

NUAK kinases: Signaling mechanisms and therapeutic applications

Nicole M. Cullen, Peter Rosston, Bakhtawar Tufail et al. Sep 01, 2025 pp. 110565 10.1016/j.jbc.2025.110565

The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation

Adrija J. Navarro-Traxler, Laura Ghisolfi, Evan C. Lien et al. Sep 01, 2025 pp. 110582 10.1016/j.jbc.2025.110582

Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations

Michael D. Onken, Carol M. Makepeace, Kevin M. Kaltenbronn et al. Sep 01, 2025 pp. 110589 10.1016/j.jbc.2025.110589

IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation

Yijun Yang, Nengyi Wang, Yuankun Chen et al. Sep 01, 2025 pp. 110560 10.1016/j.jbc.2025.110560

Peroxynitrite detoxification by Trypanosoma cruzi heme peroxidase supports parasite survival in macrophages

Vera Skafar, Matilde Abboud, Samuel L. Freeman et al. Sep 01, 2025 pp. 110533 10.1016/j.jbc.2025.110533

Two distinct protein-protein interfaces drive cooperative binding of the herpes simplex virus protein ICP8 to ssDNA, filament formation and annealing essential for viral replication

Katherine A. Discipio, Jolanta Krucinska, Renata Szczepaniak et al. Sep 01, 2025 pp. 110498 10.1016/j.jbc.2025.110498