Journal of Biological Chemistry

Full-length tau seeded by C-shaped tau fibrils is conformationally variable

Jia Yi Zhang, Nadia El Mammeri, Mei Hong Apr 01, 2026 pp. 111315 10.1016/j.jbc.2026.111315

The function of mRNA quality control in aging and age-related diseases

Seokjun G. Ha, Hyunwoo C. Kwon, Jongsun Lee et al. Apr 01, 2026 pp. 111351 10.1016/j.jbc.2026.111351

E3 ligase LMO7 enhances temozolomide sensitivity by promoting MGMT degradation in lung cancer

Jiabing Li, Xiaorong Feng, Yunfang Deng et al. Apr 01, 2026 pp. 111331 10.1016/j.jbc.2026.111331

Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition

Ruben Rosas, Luisa F. Baracaldo-Lancheros, Emily C. Dykhuizen et al. Apr 01, 2026 pp. 111344 10.1016/j.jbc.2026.111344

Allosteric properties of mammalian ALOX15 orthologs

Jiaxing Yang, Astrid Borchert, Hartmut Kuhn Apr 01, 2026 pp. 111244 10.1016/j.jbc.2026.111244

Molecular basis of fibrinogen recognition by the innate immune receptor LILRA2

Jiaqi Wang, Atsushi Furukawa, Liuan Chen et al. Apr 01, 2026 pp. 111276 10.1016/j.jbc.2026.111276

Functions of prolyl hydroxylation in elastin

Chengeng Yang, Christian E.H. Schmelzer, Anna Tarakanova Apr 01, 2026 pp. 111323 10.1016/j.jbc.2026.111323

Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex

Hao-Chi Hsu, Isabelle Bonnet, Ruslana Bryk et al. Apr 01, 2026 pp. 111284 10.1016/j.jbc.2026.111284

Sialylation in the nervous system: Functions and mechanisms

Kate Koles, Elena Repnikova, Boris Novikov et al. Apr 01, 2026 pp. 111288 10.1016/j.jbc.2026.111288

Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3, and MKK6 and the muscle recovers

Nechama Gilad, Ilona Darlyuk-Saadon, Manju Payini Mohanam et al. Apr 01, 2026 pp. 111338 10.1016/j.jbc.2026.111338

Optimization of protein UFMylation modification method and its application in substrate identification in human cells

Yaoyao Fang, Xue Wang, Juexi Dong et al. Apr 01, 2026 pp. 111320 10.1016/j.jbc.2026.111320

Landscape of splicing factors in early-onset gastric cancer reveals SRSF1 as a key driver of oxaliplatin resistance

Bin Zhong, Zhizhong Xiong, Haoyang Xu et al. Apr 01, 2026 pp. 111279 10.1016/j.jbc.2026.111279

Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens

Corinna A. Kulicke, Chance Lemon, Jason R. Krawic et al. Apr 01, 2026 pp. 111317 10.1016/j.jbc.2026.111317

Assembly of a homohexameric minichromosome maintenance complex is dependent on ATP and DNA

Oliver W. Noble, Clement Degut, Michael R. Hodgkinson et al. Apr 01, 2026 pp. 111072 10.1016/j.jbc.2025.111072

Structural insights into Phospholipase Cε activity and regulation

Ketaki A. Mahurkar, Stephanie L. Barrios, Faith D. McCauley et al. Apr 01, 2026 pp. 111289 10.1016/j.jbc.2026.111289

PLLP inhibits the progression of WT p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59

Zhenhao Quan, Lin Lin, Feipeng Xu et al. Apr 01, 2026 pp. 111341 10.1016/j.jbc.2026.111341

Deletion of Core 1 β3GalT-specific molecular chaperone (Cosmc) in murine intestinal epithelia leads to major alterations in glycocalyx and tumorigenesis

Tongzhong Ju, Yingchun Wang, Hikaru Nishio et al. Apr 01, 2026 pp. 111319 10.1016/j.jbc.2026.111319

Catalytic and structural comparisons of linoleate dioxygenases and their cytochrome P450 companions with enzymes of the cyclooxygenase cascade

Ernst H. Oliw Apr 01, 2026 pp. 111263 10.1016/j.jbc.2026.111263

Integrated analysis of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters

Yiju Zhang, Kristen C. Cooke, Jonathan Scavuzzo et al. Apr 01, 2026 pp. 111282 10.1016/j.jbc.2026.111282

Sudden death–associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1

Francisco G. Sanchez-Conde, Matthew R. Goodrich, Olivia M. Stack et al. Apr 01, 2026 pp. 111296 10.1016/j.jbc.2026.111296

Inhibition of cell surface GRP78 on brain tumors reverses drug resistance and stops cancer stem cell expansion

Elizabeth Stolarik, Jorryn Zelek, Mariah Thigpen et al. Apr 01, 2026 pp. 111146 10.1016/j.jbc.2026.111146

Glycosphingolipids in human abdominal leiomyosarcoma and liposarcoma

Chunsheng Jin, Anders Thornell, Marta Berndsen et al. Apr 01, 2026 pp. 111327 10.1016/j.jbc.2026.111327

Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D

Harry M. Williams, Alastair Watson, Jens Madsen et al. Apr 01, 2026 pp. 111307 10.1016/j.jbc.2026.111307

Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation

Jin-Ke Yang, Shuang Huang, Yuan-Pan Hou et al. Apr 01, 2026 pp. 111333 10.1016/j.jbc.2026.111333

Tryptophan metabolites 3-hydroxykynurenine (3HK) and 3-hydroxyanthranilic acid (3HAA) increase oxidative stress and impair osteoblastic bone formation

Dima W. Alhamad, Husam Bensreti, Kehong Ding et al. Apr 01, 2026 pp. 111174 10.1016/j.jbc.2026.111174