Journal of Biological Chemistry

Binding of the brain G protein G⍺o to its potential effector RASA3 is promoted by Ca2+

Halie A.S. Bell, Andrew C. Olson, Juliana E. Gentile et al. Jan 01, 2026 pp. 110999 10.1016/j.jbc.2025.110999

Bacillus subtilis encodes three N-acetylcysteine deacetylase enzymes that can catalyze the final step in S-(2-succino)cysteine breakdown

Anthony J. Zmuda, Andrew J. Toensing, Katie B. Wissbroecker et al. Jan 01, 2026 pp. 110954 10.1016/j.jbc.2025.110954

PKM2 inhibitor suppresses kidney fibrogenesis by disrupting YAP-TEAD-CCN2 transcriptional signaling following ischemia–reperfusion injury

Wakako Kosakai, Tsutomu Inoue, Tetsuya Sato et al. Jan 01, 2026 pp. 111029 10.1016/j.jbc.2025.111029

Three mammalian VDAC isoforms distinctly regulate mitochondrial function and proteome to maintain cell metabolism

Megha Rajendran, William M. Rosencrans, Nina A. Bautista et al. Jan 01, 2026 pp. 111009 10.1016/j.jbc.2025.111009

Hijacking the unfolded protein response (UPR) pathway: Balancing viral infection and host cell survival

Haoyu Chen, Duxuan Liu, Jing Hua et al. Jan 01, 2026 pp. 111040 10.1016/j.jbc.2025.111040

Phylogenetic and structural analyses reveal Cdc2-like kinases (CLKs) as ancient regulators of thermosensitive splicing

Rachel A. Ogle, Jacob K. Netherton, Benjamin R. Robinson et al. Jan 01, 2026 pp. 110979 10.1016/j.jbc.2025.110979

Small heat shock protein HSPB5 uses disorder to bind zinc with high affinity

Maria K. Janowska, Vanesa Racigh, Christoper N. Woods et al. Jan 01, 2026 pp. 111030 10.1016/j.jbc.2025.111030

Neurodevelopmental disease-causing variants in choline kinase CHKA gene couple phosphatidylcholine synthesis to oxidative stress damage and disease etiology

Mahtab Tavasoli, Mariam Alkandari, Gabriel Dorighello et al. Jan 01, 2026 pp. 110983 10.1016/j.jbc.2025.110983

Insights into chlamydial infection at the sub-cellular level using label-free Raman spectroscopy in comparison to electron microscopy

Nancy Unger, Elisabeth M. Liebler-Tenorio, Rustam R. Guliev et al. Jan 01, 2026 pp. 110940 10.1016/j.jbc.2025.110940

KANK1 regulates the positioning of liprin-α1 and the spatial organization of insulin granule fusion in pancreatic β cells

Kylie Deng, Kitty Sun, Hayley Webster et al. Jan 01, 2026 pp. 111036 10.1016/j.jbc.2025.111036

Correction: Combined deletion of cytosolic 5′-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and lowering hepatic glucose production

Roxane Jacobs, Gaëtan Herinckx, Noémie Galland et al. Jan 01, 2026 pp. 110955 10.1016/j.jbc.2025.110955

Structural basis for heme binding by the Shr protein from Streptococcus pyogenes

Kanta Seki, Akinobu Senoo, Satoru Nagatoishi et al. Jan 01, 2026 pp. 111012 10.1016/j.jbc.2025.111012

A-to-I RNA editing impairs miR-376b-3p repression of RYBP in skeletal muscle satellite cells

Xiaoli Xu, Chengqi Wei, Peijie Zeng et al. Jan 01, 2026 pp. 111006 10.1016/j.jbc.2025.111006

Detection and quantitation of ferritinophagy using HaloTag tracing

Sachin K. Kempelingaiah, Alexandra J. Straus, Grace Mavodza et al. Jan 01, 2026 pp. 111016 10.1016/j.jbc.2025.111016

Rab2A modulates liver fibroblast growth factor 21 (FGF21) expression and systemic metabolism via apolipoprotein B–CREBH signaling

Zi-yue Chen, Min Xu, Shuai Chen et al. Jan 01, 2026 pp. 110977 10.1016/j.jbc.2025.110977

Regulation of the activity of a tetra-modular lytic polysaccharide monooxygenase from Enterobacter cloacae by inter-domain copper coordination

Koyel Bardhan, Saumashish Mukherjee, Theruvothu Madathil Vandhana et al. Jan 01, 2026 pp. 110964 10.1016/j.jbc.2025.110964

Ternary complexes in protein–DNA interactions: Kinetics and mechanisms

Adina Hefetz, Elena Rogoulenko, Yaakov Levy Jan 01, 2026 pp. 111024 10.1016/j.jbc.2025.111024

Triglyceride lipase PNPLA2–independent suppression of c-MYC signaling by the metabolic coactivator ABHD5 in prostate cancer

Aaron Lotvola, Guohua Chen, Guoli Zhou et al. Jan 01, 2026 pp. 111001 10.1016/j.jbc.2025.111001

Development of a VHH that inhibits the binding of neuronal pentraxin 2 to a postsynaptic glutamate receptor, AMPAR

Takanori Yokoo, Makoto Nakakido, Keiko Matsuda et al. Jan 01, 2026 pp. 110975 10.1016/j.jbc.2025.110975

Telomere-protecting protein 1 promotes gastric cancer cell metastasis via enhancing endoplasmic reticulum stress

Zhifu Gui, Leimin Qian, Lin Gao et al. Jan 01, 2026 pp. 110998 10.1016/j.jbc.2025.110998

CAPN15 is a non-proteasomal, ubiquitin-directed calpain protease that regulates cell adhesion by cleaving E-cadherin

Aya Noguchi, Hikaru Tsuchiya, Hiroshi Shitara et al. Jan 01, 2026 pp. 111034 10.1016/j.jbc.2025.111034

Using CEST NMR to discover previously unobserved states on the free energy surface of proteins: Application to the L99A cavity mutant of T4 lysozyme

Ved Prakash Tiwari, Nihar Pradeep Khandave, D. Flemming Hansen et al. Jan 01, 2026 pp. 110989 10.1016/j.jbc.2025.110989

PIONEER: A periplasmic display platform for synthetic biology-based screening of genetically encoded protein regulators

Jacob B. Rowe, Kyutae Lee, Daniel G. Isom Jan 01, 2026 pp. 110967 10.1016/j.jbc.2025.110967

The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer

Mengna Zhu, Lin Huang, Si Sun et al. Jan 01, 2026 pp. 111011 10.1016/j.jbc.2025.111011

A truncated CDC14A retains catalytic structure and phosphatase activity preserving male fertility but causes nonsyndromic deafness

Kanwal Shabbir, Gina Jackisch, Inna A. Belyantseva et al. Jan 01, 2026 pp. 110982 10.1016/j.jbc.2025.110982