Journal of Biological Chemistry

Sertad1 is elevated and plays a necessary role in neuron loss and cognitive impairment in a mouse model of Alzheimer's disease

Naqiya Ambareen, Kusumika Gharami, Ananya Mondal et al. Dec 01, 2025 pp. 110875 10.1016/j.jbc.2025.110875

A variant of the MenB strain of Synechocystis sp. PCC 6803 disrupts a stress response pathway allowing DMPBQ to occupy the A1 sites of photosystem I

Brandon P. Russell, Vasily Kurashov, David F. Iwig et al. Dec 01, 2025 pp. 110827 10.1016/j.jbc.2025.110827

Enhanced anti-tumor activity by the combination of the natural compounds (−)-epigallocatechin-3-gallate and luteolin

A.R.M.Ruhul Amin, Dongsheng Wang, Hongzheng Zhang et al. Dec 01, 2025 pp. 110789 10.1016/j.jbc.2025.110789

A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) cleaves fibronectin and negatively regulates its fibrillogenesis

Maria Barbiera, Mikko Gynther, Tetsuya Terasaki et al. Dec 01, 2025 pp. 110844 10.1016/j.jbc.2025.110844

Structural architecture of the human long non-coding RNA-PAAN as a potential target for anti-influenza drug development

Izabela Ulanowska, Ryszard Kierzek, Elzbieta Kierzek et al. Dec 01, 2025 pp. 110755 10.1016/j.jbc.2025.110755

Redox partner adrenodoxin induces substrate binding to steroidogenic cytochrome P450 11B2 and 11A1 by promoting a conformational change

Cara L. Loomis, Michelle Redhair, Sang-Choul Im et al. Dec 01, 2025 pp. 110792 10.1016/j.jbc.2025.110792

Mechanisms underlying centriole stability

Erica Biven, Jennifer T. Wang Dec 01, 2025 pp. 110869 10.1016/j.jbc.2025.110869

Structural characterization of zebrafish Ngly2, an ovary-enriched acid PNGase required for egg-free glycan production

Akinobu Honda, Katsuhiko Kamada, Junichi Seino et al. Dec 01, 2025 pp. 110906 10.1016/j.jbc.2025.110906

Discovery and biochemical characterization of enzymes completing the 4-hydroxyphenylacetate pathway in Acinetobacter baumannii TH

Wachirawit Chinantuya, Kittipop Kungchuai, Pimchai Chaiyen et al. Dec 01, 2025 pp. 110917 10.1016/j.jbc.2025.110917

Mapping the intracellular HMGB1 interactome and alterations induced by Toll-like receptor 4 activation

Rebecka Heinbäck, Marit van der Zijde, Choi Har Tsang et al. Dec 01, 2025 pp. 110866 10.1016/j.jbc.2025.110866

A split luciferase system for studying coronavirus Mpro dimerization in vitro and in living cells

Renee Delgado, Jyoti Vishwakarma, Javier O. Sanlley Hernandez et al. Dec 01, 2025 pp. 110890 10.1016/j.jbc.2025.110890

Structural basis of nectin-4 recognition by the antibody–drug conjugate 9MW2821

Peng Fang, Meng You, Haiying Wen et al. Dec 01, 2025 pp. 110816 10.1016/j.jbc.2025.110816

Structural basis for inhibition of Mycobacterium tuberculosis α-methylacyl-CoA racemase by 2-arylthiopropanoyl-CoA inhibitor analogs

Otsile O. Mojanaga, Timothy J. Woodman, Matthew D. Lloyd et al. Dec 01, 2025 pp. 110848 10.1016/j.jbc.2025.110848

ZBP1 orchestrates dynamic transitions between cell death pathways in response to arsenic and hyperosmotic stress

Yinghao Fu, Yifan Yang, Qingqing Li et al. Dec 01, 2025 pp. 110856 10.1016/j.jbc.2025.110856

The histone methyltransferase MLL1 complex inhibits expression of fetal hemoglobin

Yufen Han, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson et al. Dec 01, 2025 pp. 110863 10.1016/j.jbc.2025.110863

Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy

Bingxue Qi, Yang Chen, Yuejiao Lan et al. Dec 01, 2025 pp. 110909 10.1016/j.jbc.2025.110909

Acetoacetate ameliorates skin fibrosis by modulating TGF-β1–Smad2/3 signaling pathway

Ting Shang, Linxiao Li, Ke Fang et al. Dec 01, 2025 pp. 110867 10.1016/j.jbc.2025.110867

Mechanistic overview of protein-specific polysialylation

Gaurang P. Bhide, Karen J. Colley Dec 01, 2025 pp. 110868 10.1016/j.jbc.2025.110868

A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases

Paola Rivera, Shuo Lu, Dignite Ngango et al. Dec 01, 2025 pp. 110850 10.1016/j.jbc.2025.110850

DNA-damage dependent isoform switching modulates RIF1 DNA repair complex assembly and phase separation

Adenine Si-Hui Koo, Weiyan Jia, Sang Hwa Kim et al. Dec 01, 2025 pp. 110857 10.1016/j.jbc.2025.110857

Mechanisms of permselectivity of connexin hemichannels to small molecules

Alexandra Lovatt, Jack Butler, Nicholas Dale Dec 01, 2025 pp. 110858 10.1016/j.jbc.2025.110858

Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA

Sushant Suresh, Alexandria L. Shaw, Damilola K. Akintola et al. Dec 01, 2025 pp. 110886 10.1016/j.jbc.2025.110886

Molecular insights into the substrate recognition and quasi-unidirectional catalysis of OpaE, an atypical fungal enzyme from the Asp/Glu racemase family

Xuehua Zheng, Zhiyong Guo, Leyao Chen et al. Dec 01, 2025 pp. 110828 10.1016/j.jbc.2025.110828

Purinergic ecto-enzyme CD73 is a context-dependent tumor suppressor in colorectal cancer

Tieu Lan Chau, Ümran Borucu, Beste Uygur et al. Dec 01, 2025 pp. 110864 10.1016/j.jbc.2025.110864

Biochemical characterization of the full-length isoform of soluble adenylyl cyclase

Jacob Ferreira, Hayden Belliveau, Lonny R. Levin et al. Dec 01, 2025 pp. 110889 10.1016/j.jbc.2025.110889