Journal of Biological Chemistry

Small RNA ASpks2 promotes Mycobacterium tuberculosis survival in macrophages via targeting polyketide synthase 2

Qian Wu, Yifei Lu, Li Yuan et al. Jun 01, 2026 pp. 111449 10.1016/j.jbc.2026.111449

Slow PPi release enhances fidelity of the SARS-CoV-2 RNA dependent RNA polymerase

Tyler L. Dangerfield, Ingrid Marko, Kenneth A. Johnson Jun 01, 2026 pp. 111457 10.1016/j.jbc.2026.111457

Minor hemolysin-coregulated proteins (Hcp) form heteromeric complexes and mediate effector secretion in Bacteroidales type VI secretion systems

Sergio G. San-Miguel, Jessica B. Hillier, Manal Kamal Saleh Al-Ammari et al. Jun 01, 2026 pp. 111464 10.1016/j.jbc.2026.111464

Biosynthetic and genetic pathways related to sialic acid metabolism

Sjanie Huang, Eline G.P. van de Ven, Trisha Tee et al. Jun 01, 2026 pp. 111262 10.1016/j.jbc.2026.111262

Domain-specific functions of LRIT3 in synaptic assembly and retinal signal transmission

Nazarul Hasan, Ronald G. Gregg Jun 01, 2026 pp. 113097 10.1016/j.jbc.2026.113097

Phosphorylation of RBM39 by CDK13 stabilizes RAD50 mRNA to drive cisplatin resistance in endometrial cancer

Chenxiao Yang, Xiaoyan Zheng, Hao Sun et al. Jun 01, 2026 pp. 111447 10.1016/j.jbc.2026.111447

Correction: Balanced production of ribosome components is required for proper G1/S transition in Saccharomyces cerevisiae

Fernando Gómez-Herreros, Olga Rodríguez-Galán, Macarena Morillo-Huesca et al. Jun 01, 2026 pp. 111411 10.1016/j.jbc.2026.111411

HECT-type ubiquitin ligases: Emerging principles in the era of full-length structures

Thornton J. Fokkens, Blanca Baños-Jaime, Sonja Lorenz Jun 01, 2026 pp. 111440 10.1016/j.jbc.2026.111440

Caveolin-1 deficiency improved glucose metabolism via modulation of β-cell autophagy in high-fat diet-fed mice

Wen Zeng, Nan Cai, Jia Liu et al. Jun 01, 2026 pp. 111480 10.1016/j.jbc.2026.111480

A novel synthetic melanin as a potential anticancer agent that induces apoptosis and cyclin D downregulation through distinct pathways

Yoshiyuki Kawamoto, Yui Furuhashi, Silvi Zakiyatul Ilmiyah et al. Jun 01, 2026 pp. 113065 10.1016/j.jbc.2026.113065

Systematic mapping of O-GlcNAc transferase and O-GlcNAcase defines disease-associated variants

Jonah Kimi, Florian Malard, Stephanie Olivier-Van Stichelen Jun 01, 2026 pp. 113134 10.1016/j.jbc.2026.113134

An artificial intelligence optimized hepatic differentiation unveils NR5A2 and AP-1 transcriptional regulation in hepatic maturation

Zijun Huo, Jian Tu, Wei-Lei Yang et al. Jun 01, 2026 pp. 111435 10.1016/j.jbc.2026.111435

Extracellular ATP drives tryptophan metabolism and aryl hydrocarbon receptor activation to promote cellular senescence

Daniela Volonte, Steven J. Mullett, Stacy L. Gelhaus et al. Jun 01, 2026 pp. 113094 10.1016/j.jbc.2026.113094

TRIM25 enhances hypoxia signaling by catalyzing K11-linked polyubiquitination and stabilization of HIF-α

Ziyi Li, Jun Li, Zhi Li et al. Jun 01, 2026 pp. 113125 10.1016/j.jbc.2026.113125

Methylation marks breast cancer metastasis: The roles of m6A-modified miRNAs and lncRNAs

Brock A. Humphries, Zhishan Wang, Chengfeng Yang Jun 01, 2026 pp. 113127 10.1016/j.jbc.2026.113127

Molecular insights into juvenile hormone maturation by juvenile hormone acid methyltransferase

Marie-Ève Picard, Michel Cusson, Rong Shi Jun 01, 2026 pp. 111474 10.1016/j.jbc.2026.111474

Allelic variation alters expression and antigen presentation of MR1 allomorphs

Adam G. Nelson, Victoria Letoga, Clarice Z.Q. Lee et al. Jun 01, 2026 pp. 111470 10.1016/j.jbc.2026.111470

Actin’s functional “switch”: Constraining C-terminal conformational flexibility disrupts functionally important communication networks

Karl E. Steffensen, John F. Dawson Jun 01, 2026 pp. 111446 10.1016/j.jbc.2026.111446

OTOP2 proton channel couples luminal pH sensing to intestinal immune homeostasis

Weihui Yan, Ying Wang, Hongxia Zhao et al. Jun 01, 2026 pp. 113105 10.1016/j.jbc.2026.113105

Transport mechanism of the SLC4 proteins—Lessons from recent structural and computational studies

Hristina R. Zhekova, Alexander Pushkin, Weiguang Wang et al. Jun 01, 2026 pp. 113092 10.1016/j.jbc.2026.113092

The Pof1 nicotinamide mononucleotide adenylyl transferase has a non-canonical role in NAD+ metabolism in the budding yeast Saccharomyces cerevisiae

Yi-Ching Lee, Chi-Chun Huang, Matilda McDaniel et al. Jun 01, 2026 pp. 111456 10.1016/j.jbc.2026.111456

Mechanism-selective inhibition of α-synuclein aggregation by the chaperone-like BRICHOS domain

Laurène Adam, Willem Hendrik Molenkamp, Jan Stanislaw Nowak et al. Jun 01, 2026 pp. 113117 10.1016/j.jbc.2026.113117

Calcium-loaded acylated segment controls membrane penetration capacity of repeats-in-toxin cytolysins

Jiri Masin, Adriana Osickova, Zuzana Kalaninova et al. Jun 01, 2026 pp. 113079 10.1016/j.jbc.2026.113079

The chromatin reader ZMYND8 recruits the NuRD component GATAD2A through its MYND domain to regulate MAPT213 long noncoding RNA transcription

Dushyant Kumar Srivastava, Sandhik Nandi, Avradeep Karmakar et al. Jun 01, 2026 pp. 111463 10.1016/j.jbc.2026.111463

Structural basis of phosphodiesterase-5 conformational organization revealed by a PDE6/PDE5 chimera

Dhiraj Srivastava, Sneha Singh, Chris Yu et al. Jun 01, 2026 pp. 111467 10.1016/j.jbc.2026.111467