Journal of Biological Chemistry

Molecular interactions of the NaV1.5 C-terminal domain: CaM sequestered the IQ motif from the CTD

Rita F. Gyawu, Torien M. Beard, Svetlana Tikunova et al. Dec 01, 2025 pp. 110871 10.1016/j.jbc.2025.110871

Lipopolysaccharide-induced cytokine signaling activates a temporal innate defense program and represses pancreatic β-cell identity

Jacob T. Bartosiak, Polly A. Hansen, Elaine A. Schumacher et al. Dec 01, 2025 pp. 110811 10.1016/j.jbc.2025.110811

Viral interference of nucleocytoplasmic transport

Chia-Yu Chien, George W. Mobbs, Joel Ehrenkranz et al. Dec 01, 2025 pp. 110815 10.1016/j.jbc.2025.110815

YAP-mediated glycolysis promotes pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension

Wenhua Shi, Liping Chen, Wei Zhang et al. Dec 01, 2025 pp. 110836 10.1016/j.jbc.2025.110836

The DID of CAPS-1 anchors plasma membrane to promote vesicle exocytosis

Li Zhang, Yuwan Dai, Ting Sun et al. Dec 01, 2025 pp. 110902 10.1016/j.jbc.2025.110902

Pathogenic variants in KCTD1 disrupt cAMP signaling and cellular communication associated with developmental pathways

Yini Liao, Brian S. Muntean Dec 01, 2025 pp. 110813 10.1016/j.jbc.2025.110813

Auxin-induced depletion of human CCR4-NOT subunits reveals opposing functions of CNOT1 and CNOT4 in mRNA metabolism

Shardul Kulkarni, Courtney Smith, Oluwasegun T. Akinniyi et al. Dec 01, 2025 pp. 110862 10.1016/j.jbc.2025.110862

SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase

Emma E. Drew, Hunter G. Nyvall, Matthew A.H. Parson et al. Dec 01, 2025 pp. 110788 10.1016/j.jbc.2025.110788

Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences

Nina Kastner, Mohammad N. Islam, Michael Dybek et al. Dec 01, 2025 pp. 110903 10.1016/j.jbc.2025.110903

Endocannabinoid oxygenation by prostaglandin H synthase-2: Chemistry and biology

Carol A. Rouzer, Lawrence J. Marnett Dec 01, 2025 pp. 110870 10.1016/j.jbc.2025.110870

Structure and substrate promiscuity of Campylobacter jejuni periplasmic nitrate reductase (Nap) and phylogenetic analysis of Nap homologs

Nitai C. Giri, Trung Thach, KanagaVijayan Dhanabalan et al. Dec 01, 2025 pp. 110928 10.1016/j.jbc.2025.110928

The proton-sensing OGR1 receptor and hypoxia-inducible factors promote metal ion–induced inflammatory responses in coronary artery smooth muscle cells

Koichi Sato, Chihiro Mogi, Haruka Aoki-Saito et al. Dec 01, 2025 pp. 110842 10.1016/j.jbc.2025.110842

Farnesyl pyrophosphate synthase promotes restenosis after vascular injury by activating small G proteins

Xiaowei Liu, Lin Yang, Zhi Zhang et al. Dec 01, 2025 pp. 110861 10.1016/j.jbc.2025.110861

Simultaneous ligand binding to intact and partially formed ATP-binding sites in the hexameric termination factor Rho

Tyler D. Billings, Kristie Baker, Philip Lacey et al. Dec 01, 2025 pp. 110797 10.1016/j.jbc.2025.110797

Structures of a lipin/Pah phosphatidic acid phosphatase in distinct catalytic states reveal a signature motif for substrate recognition

Tereza Vitkovska, Franceine S. Welcome, Valerie I. Khayyo et al. Dec 01, 2025 pp. 110830 10.1016/j.jbc.2025.110830

Dissecting stress-activated protein kinase (SAPK)–signaling pathways using multiplex gene knockout HeLa cells

Chihiro Ito, Mirei Yamamoto, Nozomi Yokota et al. Dec 01, 2025 pp. 110901 10.1016/j.jbc.2025.110901

Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3

Solomiia Boyko, Qiuye Li, Krystyna Surewicz et al. Dec 01, 2025 pp. 110849 10.1016/j.jbc.2025.110849

Cyclophilin D is a new non-canonical substrate of the mitochondrial intermembrane space assembly pathway

Mara Equisoain Redin, Veronica Bazzani, Eve Harding et al. Dec 01, 2025 pp. 110883 10.1016/j.jbc.2025.110883

The m6A reader YTHDF1 facilitates nasopharyngeal carcinoma proliferation and migration via c-MYC

Ping Han, Zhiwen Xiao, Tianliang Xia et al. Dec 01, 2025 pp. 110833 10.1016/j.jbc.2025.110833

Mechanism of NUMBL enhancing axitinib resistance in clear cell renal cell carcinoma by UCHL1-mediated deubiquitination of MMP9

Ziyi Wang, Lian Chen, Hang Zhang et al. Dec 01, 2025 pp. 110873 10.1016/j.jbc.2025.110873

The organic cation transporters 1 and 2 mediate ethanolamine cellular efflux and control systemic phosphatidylethanolamine level

Julia Schubert, Ferhat Koca, Francesca Barone et al. Dec 01, 2025 pp. 110911 10.1016/j.jbc.2025.110911

The Hippo kinases MST1/2 integrate sterile and infectious signals to regulate macrophage cell death

Sydney M. Quagliato, Matthew Gulker, Ryan Mirhosiny et al. Dec 01, 2025 pp. 110920 10.1016/j.jbc.2025.110920

C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases

Stefanie J. Hodapp, Tiffany H. Kao, Jian Wu et al. Dec 01, 2025 pp. 110921 10.1016/j.jbc.2025.110921

LPS induces limited activation of hypoxia-inducible factor-1α in macrophages

Takayuki Isagawa, Masaki Suimye Morioka, Hiroaki Semba et al. Dec 01, 2025 pp. 110932 10.1016/j.jbc.2025.110932

The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly

Alexandra Rita Turi da Fonte Dias, Ingrid Hoffmann Dec 01, 2025 pp. 110785 10.1016/j.jbc.2025.110785