Journal of Biological Chemistry

HDAC6-mediated PFKL deacetylation enhances aerobic glycolysis and promotes VSMC proliferation

Zhao-Kun Hu, Zhi-Yan Ren, Jie-Xin Pang et al. Feb 01, 2026 pp. 111075 10.1016/j.jbc.2025.111075

Chaperone-assisted expression and purification of the AML-associated Src-family kinase Fgr in Escherichia coli

Giancarlo Gonzalez-Areizaga, Thomas E. Smithgall Feb 01, 2026 pp. 111099 10.1016/j.jbc.2025.111099

A pathway for D-cysteinolate degradation in sulfate- and sulfite-reducing bacteria

Xumei Liu, Yiling Hu, Junwei An et al. Feb 01, 2026 pp. 111055 10.1016/j.jbc.2025.111055

The biochemical dynamics of the glycogen phosphatase laforin directly impact brain metabolism

M.Kathryn Brewer, Katherine J. Donohue, Pankaj K. Singh et al. Feb 01, 2026 pp. 111097 10.1016/j.jbc.2025.111097

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

Sean McNeme, Yun Young Yim, Ashwani Kumar et al. Feb 01, 2026 pp. 111080 10.1016/j.jbc.2025.111080

Enzymatic basis of branching and extension of O-Man glycans for keratan sulfate biosynthesis

Tomoya Itoh, Hide-Nori Tanaka, Mohit Pareek et al. Feb 01, 2026 pp. 111140 10.1016/j.jbc.2026.111140

Direct optical activation of human IRE1 identifies unique patterns of transcriptional and post-transcriptional mRNA regulation in the unfolded protein response

Jacob W. Smith, Damien B. Wilburn, Vladislav Belyy Feb 01, 2026 pp. 111067 10.1016/j.jbc.2025.111067

Author response to “Commentary on detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat” by Dr. Latika Shendre

Herbert Michlmayr, Anastassios C. Papageorgiou Feb 01, 2026 pp. 111139 10.1016/j.jbc.2026.111139

Sialoglycans on human T cells attenuate death programs executed through the Fas pathway

Vanessa Affe, Qianmeng Lei, Tim S. Veth et al. Feb 01, 2026 pp. 111047 10.1016/j.jbc.2025.111047

Catechol-linker and receptor-mediated site-specific delivery of bortezomib against non-small cell lung cancer

Mohan Indhu, Valappil Sisila, Devandran Jayasurya et al. Feb 01, 2026 pp. 111095 10.1016/j.jbc.2025.111095

Lipopeptide ligands captured by MHC class I molecules undergo dynamic conformational changes that affect their antigenic strength

Daisuke Morita, Toshiki Fujii, Shinsuke Inuki et al. Feb 01, 2026 pp. 111049 10.1016/j.jbc.2025.111049

The role of DNAJC3 in enhancing glioma progression and regulating the tumor immune microenvironment

Yinmin Shi, Wenxia Wang, Chenyang Liu et al. Feb 01, 2026 pp. 111059 10.1016/j.jbc.2025.111059

Noncanonical lipooligosaccharide assembly in Acinetobacter baumannii is mediated by the glycosyltransferases KdoT and GnaT

Leah M. VanOtterloo, Bradley J. Voss, M. Stephen Trent Feb 01, 2026 pp. 111103 10.1016/j.jbc.2025.111103

MRPL47 deficiency drives mitochondrial dysfunction via ROS-p38-p21 signaling in non-small cell lung cancer

Nikita Bhandari, Yengkhom Ghanapriya Devi, Disha Acharya et al. Feb 01, 2026 pp. 111058 10.1016/j.jbc.2025.111058

A cell-specific computational framework reveals a pan-cancer hypoxia signature predicting overall survival and ICI response

Caiyu Zhang, Yitong Jin, Yifangfei Yu et al. Feb 01, 2026 pp. 111068 10.1016/j.jbc.2025.111068

A career in bioactive lipids

Yusuf A. Hannun Feb 01, 2026 pp. 111041 10.1016/j.jbc.2025.111041

Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes

Lindsey N. Power, Natalia Zawrotna, Manikarna Dinda et al. Feb 01, 2026 pp. 111062 10.1016/j.jbc.2025.111062

Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates

Joshua Lugo, Hui Xu, Jeannie Chen et al. Feb 01, 2026 pp. 111048 10.1016/j.jbc.2025.111048

Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity

Yi Wang, Yanfei Hou, Jing Han et al. Feb 01, 2026 pp. 111038 10.1016/j.jbc.2025.111038

GRIA1 regulates TGN export and secretion of Sonic hedgehog

Xiao Tang, Ye Tian, Qianyuan Wang et al. Feb 01, 2026 pp. 111084 10.1016/j.jbc.2025.111084

Targeting the protein–protein interaction between the CDC37 cochaperone and client kinases by an allosteric RAF dimer breaker

Alison Yu, Shrhea Banerjee, sravani malasani et al. Feb 01, 2026 pp. 111018 10.1016/j.jbc.2025.111018

The long non-coding RNA MALAT1 encodes a micropeptide that promotes influenza A virus replication by suppressing innate immune responses

Kul Raj Rai, Faxin Wen, Mohamed Maarouf et al. Feb 01, 2026 pp. 111112 10.1016/j.jbc.2025.111112

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly

Ushma Anand, Amit Bloomberg, Pradip Bhattacharjee et al. Feb 01, 2026 pp. 111104 10.1016/j.jbc.2025.111104

AGEs promote the metastasis of colorectal cancer cells via centrosome amplification by KLF5–CEP57L1 axis

Ji Zhong Zhao, Sheng Xian Fan, Jia Li Guo et al. Feb 01, 2026 pp. 111098 10.1016/j.jbc.2025.111098

Methyl-CpG-binding protein 2 reads histone methylation via an aromatic cage to regulate gene expression and chromatin association

Jyotirmayee Padhan, Babu Sudhamalla Feb 01, 2026 pp. 111115 10.1016/j.jbc.2025.111115