Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

Sean McNeme; Yun Young Yim; Ashwani Kumar; Yi Li; Brandon Hughes; Corey Peyton St Romain; Galina Aglyamova; Jianping Chen; Nghi D. Nguyen; Shanghua Fan; Gabriel S. Stephens; Wen-Ning Zhao; Samantha Kruzshak; Molly Estill; Corrine Brener; Solange Tofani; Anil Kumar; Earnest P. Chen; Nadeen Takatka; Alfred J. Robison; Haiying Chen; Reid T. Powell; Stephen J. Haggarty; Clifford Stephan; Eric J. Nestler; Jeannie Chin; Mischa Machius; Jia Zhou; Gabby Rudenko

doi:10.1016/j.jbc.2025.111080

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

S Sean McNeme Y Yun Young Yim A Ashwani Kumar Y Yi Li B Brandon Hughes C Corey Peyton St Romain G Galina Aglyamova J Jianping Chen N Nghi D. Nguyen S Shanghua Fan G Gabriel S. Stephens W Wen-Ning Zhao S Samantha Kruzshak M Molly Estill C Corrine Brener S Solange Tofani A Anil Kumar E Earnest P. Chen N Nadeen Takatka A Alfred J. Robison H Haiying Chen R Reid T. Powell S Stephen J. Haggarty C Clifford Stephan E Eric J. Nestler J Jeannie Chin M Mischa Machius J Jia Zhou G Gabby Rudenko

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Article Details

Journal Journal of Biological Chemistry

Volume / Issue Vol. 302, Issue 2

Published February 01, 2026

Pages 111080

DOI 10.1016/j.jbc.2025.111080

ISSN 0021-9258

Publisher Elsevier BV

Journal Info

Journal of Biological Chemistry

Elsevier BV

ISSN: 0021-9258 Open Access Life Sciences

Authors (29)

S

Sean McNeme

Y

Yun Young Yim

A

Ashwani Kumar

Y

Yi Li

B

Brandon Hughes

C

Corey Peyton St Romain

G

Galina Aglyamova

J

Jianping Chen

N

Nghi D. Nguyen

S

Shanghua Fan

G

Gabriel S. Stephens

W

Wen-Ning Zhao

S

Samantha Kruzshak

M

Molly Estill

C

Corrine Brener

S

Solange Tofani

A

Anil Kumar

E

Earnest P. Chen

N

Nadeen Takatka

A

Alfred J. Robison

H

Haiying Chen

R

Reid T. Powell

S

Stephen J. Haggarty

C

Clifford Stephan

E

Eric J. Nestler

J

Jeannie Chin

M

Mischa Machius

J

Jia Zhou

G

Gabby Rudenko

Discovery of small molecules and a druggable groove that regulate DNA binding and release of the AP-1 transcription factor ΔFOSB

Article Details

Journal Info

Authors (29)

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