Journal of Biological Chemistry

Unique bifunctional α-sialidase/β-N-acetylgalactosaminidase from Bifidobacterium bifidum acting on the Sda antigen

Toshihiko Katoh, Rina Suzuki, Shogo Kataoka et al. Feb 01, 2026 pp. 111121 10.1016/j.jbc.2025.111121

Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome

Cynthia X. Hou, Amelia Brasnett, Patrick Rabe et al. Feb 01, 2026 pp. 111008 10.1016/j.jbc.2025.111008

Structural and functional insights into calmodulin-mediated lipid binding and proteolytic cleavage of the M-PMV matrix protein

Karolina Buresova, Tereza Nesporova, Jan Prchal et al. Feb 01, 2026 pp. 111102 10.1016/j.jbc.2025.111102

Regulating the orientation of homobivalent small binders through 3D domain-swapping design

Shota Shiga, Hideki Watanabe, Koki Makabe et al. Feb 01, 2026 pp. 111053 10.1016/j.jbc.2025.111053

ANP32A-mediated histone 3 K27 acetylation is essential for sotorasib activity in KRAS-mutant non–small cell lung cancer

Kailing Pan, Mingjing Dang, Bo Xu et al. Feb 01, 2026 pp. 111110 10.1016/j.jbc.2025.111110

Hyaluronic acid regulates cellular UDP-GlcNAc levels through CD44 to affect glycosylation and cell biological functions

Yue Wang, Tomoya Isaji, Tiangui Wu et al. Feb 01, 2026 pp. 111111 10.1016/j.jbc.2025.111111

Allosteric zinc inhibition and interdomain regulation govern the catalytic mechanism of the E3-independent ubiquitin-conjugating enzyme hUBE2O

Dan Xiang, Xiaoxiao Tang, Ruona Shi et al. Feb 01, 2026 pp. 111122 10.1016/j.jbc.2025.111122

Enhanced lysosomal activity prevents infection with PrPSc and the seeding activity of α-synuclein & tau prions

Robert C.C. Mercer, Nhat T.T. Le, Nadia A. Mirza-Romero et al. Feb 01, 2026 pp. 111050 10.1016/j.jbc.2025.111050

Nanobodies against Clostridioides difficile CDTb provide a toolkit for potent toxin neutralization and highly sensitive quantitation

Kateryna Nabukhotna, Heather K. Kroh, David M. Anderson et al. Feb 01, 2026 pp. 111082 10.1016/j.jbc.2025.111082

Neurofascin stabilization by contactin-associated protein-like 2 and CTCF alleviates mitochondrial dysfunction in Schwann cells during facial nerve injury

Jin Zhu, Xin Ouyang, Lifu Yu et al. Feb 01, 2026 pp. 111090 10.1016/j.jbc.2025.111090

A reversible feedback mechanism regulating mitochondrial heme synthesis

Iva Chitrakar, Alexis B. Roberson, Pedro H. Ayres-Galhardo et al. Feb 01, 2026 pp. 111089 10.1016/j.jbc.2025.111089

Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation

Amanda L. Bohanon, Luke S. Browning, Andrea Piserchio et al. Feb 01, 2026 pp. 111087 10.1016/j.jbc.2025.111087

A neural glycan HNK-1 is transferred to recipient cells via small extracellular vesicles

Yuko Tokoro, Yasuhiko Kizuka Feb 01, 2026 pp. 111144 10.1016/j.jbc.2026.111144

Threonyl-tRNA synthetase activates STAT3 by a nontranslational mechanism

Pallob Barai, Reean Abdullah, Shruti V. Bendre et al. Feb 01, 2026 pp. 111032 10.1016/j.jbc.2025.111032

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma

David Gau, Pooja Chawla, Kexin Xu et al. Feb 01, 2026 pp. 111033 10.1016/j.jbc.2025.111033

Nuclear myosin VI cooperates with actin to promote transcriptional cluster formation at androgen receptors

Irma M. Jayawardana, Justus M. Fleisch, Julian Knerr et al. Feb 01, 2026 pp. 111088 10.1016/j.jbc.2025.111088

Correction: P3 site-directed mutagenesis: An efficient method based on primer pairs with 3′-overhangs

Negar Mousavi, Ethan Zhou, Arezousadat Razavi et al. Feb 01, 2026 pp. 111129 10.1016/j.jbc.2025.111129

A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels

Fabian M.B. Thöne, Maya M. Polovitskaya, Uta E. Höpken et al. Feb 01, 2026 pp. 111060 10.1016/j.jbc.2025.111060

TIM-3 inhibition enhances breast tumor progression and metastasis: A paradoxical immune checkpoint response

Barnali Dolui, Banani Majumdar, Arghya Bandyopadhyay et al. Feb 01, 2026 pp. 111096 10.1016/j.jbc.2025.111096

B3GNT8-mediated glycosylation maintains intestinal homeostasis and protects against colitis

Haoyun Mao, Yi Cao, Ying Lu et al. Feb 01, 2026 pp. 111014 10.1016/j.jbc.2025.111014

Dynamic and extensive A-to-I RNA recoding in immunoglobulin shapes myeloid neoplasm transcriptome

Qi Cao, Yuqing Wang, Yuange Duan Feb 01, 2026 pp. 111066 10.1016/j.jbc.2025.111066

The role of acyl cycling in endogenous G protein localization

Wonjo Jang, Kanishka Senarath, Sumin Lu et al. Feb 01, 2026 pp. 111045 10.1016/j.jbc.2025.111045

Conserved early steps of stemmadenine biosynthesis

Mohamed O. Kamileen, Yoko Nakamura, Marlen Sigmund et al. Feb 01, 2026 pp. 111120 10.1016/j.jbc.2025.111120

Sterile innate immune mechanisms in neurodegenerative diseases

Alyssa Ealy, Amanda M. Serapiglia, Nikhil Panicker Feb 01, 2026 pp. 111039 10.1016/j.jbc.2025.111039

Clostridioides difficile TcdB induces expression of its receptor (CSPG4) through a noncanonical Hippo signaling mechanism

Jason L. Larabee, Elizabeth J. Donald, Anushka A. Sukhadia et al. Feb 01, 2026 pp. 111137 10.1016/j.jbc.2026.111137