Journal of Biological Chemistry

Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in Caenorhabditis elegans models of Alzheimer’s disease

Lihua Sun, Jiahui Liu, Menghan Lu et al. Jun 01, 2025 pp. 110226 10.1016/j.jbc.2025.110226

Challenging activity and signaling bias in tachykinin NK1 and NK2 receptors by truncated neuropeptides

Jacob E. Petersen, Artem Pavlovskyi, Jesper J. Madsen et al. Jun 01, 2025 pp. 108522 10.1016/j.jbc.2025.108522

The mechanism of peptidoglycan O-acetylation in Gram-negative bacteria typifies bacterial MBOAT-SGNH acyltransferases

Alexander C. Anderson, Bailey J. Schultz, Eric D. Snow et al. Jun 01, 2025 pp. 108531 10.1016/j.jbc.2025.108531

Seo1p, a high-affinity, plasma membrane transporter of the γ-Glu-met dipeptide in yeasts and fungi

Pratiksha Dubey, Md Shabbir Ahmad, Sunil Laxman et al. Jun 01, 2025 pp. 108539 10.1016/j.jbc.2025.108539

Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export

Leena S. Kariapper, Ila A. Marathe, Ashley B. Niesman et al. Jun 01, 2025 pp. 110171 10.1016/j.jbc.2025.110171

Fluorescent labeling of proteins in vitro and in vivo using encoded peptide tags

Maya de Luis, Shuwa Xu, Kai Zinn Jun 01, 2025 pp. 110229 10.1016/j.jbc.2025.110229

Extent of N-glycosylation of the metalloproteinase inhibitor and cytokine TIMP-1 determines pancreatic cancer cell proliferation and survival via CD63

Daniel Häußler, Damjan Manevski, Julian Frädrich et al. Jun 01, 2025 pp. 110211 10.1016/j.jbc.2025.110211

The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state

Anthony Balistreri, Divya Kolli, Sanduni Wasana Jayaweera et al. Jun 01, 2025 pp. 110217 10.1016/j.jbc.2025.110217

A tumor necrosis factor-α–responsive cryptic promoter drives overexpression of the human endogenous retrovirus ERVK-7

Sojung Lee, Yin Yee Ho, Suyu Hao et al. Jun 01, 2025 pp. 108568 10.1016/j.jbc.2025.108568

EML2 and EML4 splice variants regulate microtubule remodeling during neuronal cell differentiation

Venus Marasi, Rozita Adib, Laura O’Regan et al. Jun 01, 2025 pp. 110252 10.1016/j.jbc.2025.110252

CRISPRi screen uncovers lncRNA regulators of human monocyte growth

Cristina Flores-Arenas, Eric Malekos, Christy Montano et al. Jun 01, 2025 pp. 110204 10.1016/j.jbc.2025.110204

Selective inhibition of TRPV3 channel by natural rosmarinic acid and its analogs for alleviation of skin lesions through downregulation of NF-κB pathway

Yaxuan Qu, Shilun Mo, Fei Hou et al. Jun 01, 2025 pp. 110267 10.1016/j.jbc.2025.110267

MitoSNO inhibits mitochondrial hydrogen peroxide generation by α-ketoglutarate dehydrogenase

Olivia Chalifoux, Samantha Sterman, Ben Faerman et al. Jun 01, 2025 pp. 108510 10.1016/j.jbc.2025.108510

Molecular glue binding behavior of phosphoantigens to alpaca butyrophilins

Chang Liu, Simin Yi, Mengting Zhang et al. Jun 01, 2025 pp. 108555 10.1016/j.jbc.2025.108555

RIPC improves myocardial injury by promoting mitochondrial protection via the PGC-1α/Nrf2 pathway

Zhenzhou Zhao, Zhiwen Zhang, Xuejie Li et al. Jun 01, 2025 pp. 108476 10.1016/j.jbc.2025.108476

Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver

Sezin Dagdeviren, Megan F. Hoang, Jialu Wang et al. Jun 01, 2025 pp. 110214 10.1016/j.jbc.2025.110214

All intrinsically active Erk1/2 mutants autophosphorylate threonine207/188, a plausible regulator of the TEY motif phosphorylation

Alexey Baskin, Nadine Soudah, Nechama Gilad et al. Jun 01, 2025 pp. 108509 10.1016/j.jbc.2025.108509

Blockade of the estrogen receptor alpha–pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity

Elizabeth Twum, Malvin Ofosu-Boateng, Daniel O. Nnamani et al. Jun 01, 2025 pp. 110238 10.1016/j.jbc.2025.110238

Hepatic ChREBP reciprocally modulates systemic insulin sensitivity in NAFLD

Aniket Sen, Shilpa Thakur, Priya Rawat et al. Jun 01, 2025 pp. 108556 10.1016/j.jbc.2025.108556

A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes

Xiaoxiao Hao, Yuechuan Chen, Divya Sahu et al. Jun 01, 2025 pp. 110172 10.1016/j.jbc.2025.110172

Directed evolution of metalloproteinase inhibitor TIMP-1 for selective inhibition of MMP-9 exploits catalytic and fibronectin domain interactions

Alireza Shoari, Mathew A. Coban, Alexandra Hockla et al. Jun 01, 2025 pp. 110258 10.1016/j.jbc.2025.110258

LncRNA-induced lysosomal localization of NHE1 promotes increased lysosomal pH in macrophages leading to atherosclerosis

Pengcheng Shi, Bo Tang, Wen Xie et al. Jun 01, 2025 pp. 110246 10.1016/j.jbc.2025.110246

A high-throughput compatible workflow for the biochemical identification and characterization of molecular glues

Ryan Guilbert, Maxime Couturier, Yuanyuan Si et al. Jun 01, 2025 pp. 108526 10.1016/j.jbc.2025.108526

Ebola virus nucleoprotein interaction with host protein phosphatase-1 regulates its dimerization and capsid formation

Asrar Ahmad, Bersabeh Tigabu, Andrey Ivanov et al. Jun 01, 2025 pp. 108541 10.1016/j.jbc.2025.108541

In vitro sulfuration of Rhodobacter capsulatus formate dehydrogenase

Benjamin R. Duffus, Benedict J. Elvers, Christian Teutloff et al. Jun 01, 2025 pp. 108511 10.1016/j.jbc.2025.108511