Journal of Biological Chemistry

MYC controls STING levels to downregulate inflammatory signaling in breast cancer cells upon DNA damage

Renske Linstra, Chantal Stappenbelt, Femke J. Bakker et al. Jun 01, 2025 pp. 108560 10.1016/j.jbc.2025.108560

Redox response feature and mechanism of Arf1 and their implications for those of Ras and Rho GTPases

Hope Elizabeth Johnson, Emilynn Leigh Banks, Ostin Samuel Ozuna et al. Jun 01, 2025 pp. 110269 10.1016/j.jbc.2025.110269

Structural and functional insights into the substrate specificity of the pseudouridine monophosphate phosphatase HDHD1A

Suyoung Seo, Minsoo Kim, Sangkee Rhee Jun 01, 2025 pp. 110257 10.1016/j.jbc.2025.110257

Variations in kinase and effector signaling logic in a bacterial two component signaling network

Danielle Swingle, Leah Epstein, Ramisha Aymon et al. Jun 01, 2025 pp. 108534 10.1016/j.jbc.2025.108534

Quantification and structure–function analysis of calpain-1 and calpain-2 protease subunit interactions

Ivan Shapovalov, Prawin Rimal, Pitambar Poudel et al. Jun 01, 2025 pp. 110243 10.1016/j.jbc.2025.110243

The VanS sensor histidine kinase from type-B vancomycin-resistant enterococci recognizes vancomycin directly

Lina J. Maciunas, Photis Rotsides, Elizabeth J. D’Lauro et al. Jun 01, 2025 pp. 110276 10.1016/j.jbc.2025.110276

Connecting the dots: Epigenetic regulation of extrachromosomal and inherited DNA amplifications

Chloe Azadegan, John Santoro, Johnathan R. Whetstine Jun 01, 2025 pp. 108454 10.1016/j.jbc.2025.108454

Acid sphingomyelinase recruits palmitoylated CD36 to membrane rafts and enhances lipid uptake

Meng Ding, Yun Zhang, Xiaoting Xu et al. Jun 01, 2025 pp. 110213 10.1016/j.jbc.2025.110213

Alternative splicing categorizes organ development by stage and reveals unique human splicing variants linked to neuromuscular disorders

Chen Li, Fu-xing Gong, Zhigang Yang et al. Jun 01, 2025 pp. 108542 10.1016/j.jbc.2025.108542

NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation

Yingshi Zhou, Zhihuai Deng, Shiyu Xiong et al. Jun 01, 2025 pp. 108551 10.1016/j.jbc.2025.108551

A new age in structural S-layer biology: Experimental and in silico milestones

Stephanie Grill-Walcher, Christina Schäffer Jun 01, 2025 pp. 110205 10.1016/j.jbc.2025.110205

Molecular basis for differential PIP2-mediated association between vinculin and its splice isoform metavinculin

Mohammad Ashhar I. Khan, Venkat R. Chirasani, Muzaddid Sarker et al. Jun 01, 2025 pp. 110232 10.1016/j.jbc.2025.110232

Loss of SLX4IP leads to common fragile site instability and compromises DNA interstrand crosslink repair in vivo

Andreas Ingham, Mukundhan Ramaswami, Ramanagouda Ramangoudr-Bhojappa et al. Jun 01, 2025 pp. 110244 10.1016/j.jbc.2025.110244

Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics

Zachary S.C.S. Froom, Neal I. Callaghan, Locke Davenport Huyer Jun 01, 2025 pp. 110203 10.1016/j.jbc.2025.110203

The macrophage sterol transport protein ORP2 promotes cholesterol efflux and prevents foam cell formation and atherosclerosis

Xiaowei Wang, Kenan Peng, Yudi Zhao et al. Jun 01, 2025 pp. 110228 10.1016/j.jbc.2025.110228

Tamoxifen induces protection against manganese toxicity by REST upregulation via the ER-α/Wnt/β-catenin pathway in neuronal cells

Alexis Digman, Edward Pajarillo, Sanghoon Kim et al. Jun 01, 2025 pp. 108529 10.1016/j.jbc.2025.108529

Phosphorylation modulates secondary structure of intrinsically disorder regions in RNA polymerase II

Wei Chen, Tatiana N. Laremore, Neela H. Yennawar et al. Jun 01, 2025 pp. 108533 10.1016/j.jbc.2025.108533

The neural stem cell gene PAFAH1B1 controls cell cycle progression, DNA integrity, and paclitaxel sensitivity of triple-negative breast cancer cells

Parth R. Majmudar, Ruth A. Keri Jun 01, 2025 pp. 110235 10.1016/j.jbc.2025.110235

CMP-sialic acid synthetase in Drosophila requires N-glycosylation of a noncanonical site

Boris Novikov, Devon J. Boland, Ilya Mertsalov et al. Jun 01, 2025 pp. 108483 10.1016/j.jbc.2025.108483

Engineering an antimicrobial chimeric endolysin that targets the phytopathogen Pseudomonas syringae pv. actinidiae

Suzanne L. Warring, Hazel M. Sisson, George Randall et al. Jun 01, 2025 pp. 110224 10.1016/j.jbc.2025.110224

A cobalamin-dependent pathway of choline demethylation from the human gut acetogen Eubacterium limosum

Ruisheng Jiang, Duncan J. Kountz, Liwen Zhang et al. Jun 01, 2025 pp. 108524 10.1016/j.jbc.2025.108524

Phase separation as a key mechanism in plant development, environmental adaptation, and abiotic stress response

Karina C. Pougy, Bruna A. Brito, Giovanna S. Melo et al. Jun 01, 2025 pp. 108548 10.1016/j.jbc.2025.108548

A strategy for liver selective NRF2 induction via cytochrome P450-activated prodrugs with low activity in hypoxia

Mei Ying Ng, Thilo Hagen Jun 01, 2025 pp. 108487 10.1016/j.jbc.2025.108487

Identification of UDP-dependent glycosyltransferases in the wallflower cardenolide biosynthesis pathway

Owen S. Patrick, Gordon C. Younkin, Rebecca G. Brody et al. Jun 01, 2025 pp. 108565 10.1016/j.jbc.2025.108565

High-frequency transcription leads to rapid R-loop formation

Bradleigh Palmer, Chun-Ying Lee, Leya Yang et al. Jun 01, 2025 pp. 108514 10.1016/j.jbc.2025.108514