Journal of Biological Chemistry

First-in-class inhibitors of Nsp15 endoribonuclease of SARS-CoV-2: Modeling, synthesis, and enzymatic assay of thiazolidinedione and rhodanine analogs

Nimer Mehyar, Nosaibah Samman, Shatha Al Gheribi et al. Aug 01, 2025 pp. 110409 10.1016/j.jbc.2025.110409

Hypoxia-inducible factor 1α in Schwann cells promotes peripheral nerve myelination

Yuka Kobayashi-Ujiie, Shuji Wakatsuki, Yurika Numata-Uematsu et al. Aug 01, 2025 pp. 110433 10.1016/j.jbc.2025.110433

CryoEM structure of Rv2531c reveals cofactor-induced tetramer–dimer transition in a tuberculin amino acid decarboxylase

Jyoti Gupta, Tina Izard Aug 01, 2025 pp. 110394 10.1016/j.jbc.2025.110394

Regulation of steady state ribosomal transcription in Mycobacterium tuberculosis: Intersection of sigma subunits, superhelicity, and transcription factors

Ana Ruiz Manzano, Drake Jensen, Eric A. Galburt Aug 01, 2025 pp. 110369 10.1016/j.jbc.2025.110369

Leber's hereditary optic neuropathy–associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis

Meiheriayi Yasheng, Yanchun Ji, Yunfan He et al. Aug 01, 2025 pp. 110464 10.1016/j.jbc.2025.110464

GAPDH heme delivery to Indoleamine 2,3-dioxygenase 1 involves their complex formation and complementary charge pairing at the protein-protein interface

Pranjal Biswas, Yue Dai, Dhanya T. Jayaram et al. Aug 01, 2025 pp. 110443 10.1016/j.jbc.2025.110443

PAXX/Ku interaction is rate limiting for repair of double-strand DNA breaks requiring end processing

Joanna Gluza, Joanna Machnik, Malgorzata Szatkiewicz et al. Aug 01, 2025 pp. 110481 10.1016/j.jbc.2025.110481

Phosphorylation-mediated regulation of the NADPH-dependent glutamate dehydrogenase, SpGdh1, from Schizosaccharomyces pombe

Yi-Fan Wang, Takeo Tomita, Ayako Yoshida et al. Aug 01, 2025 pp. 110422 10.1016/j.jbc.2025.110422

Acetylation of microtubule-binding PinX1 orchestrates ribosome biogenesis to nutrient starvation via the RNA polymerase I preinitiation complex

Gang Lu, Liqian Yang, Qinxin Zhang et al. Aug 01, 2025 pp. 110465 10.1016/j.jbc.2025.110465

O-GlcNAcylation of fatty acid synthase is required for its proper subcellular localization, expression level, and activity

Dimitri Vanauberg, Céline Schulz, Sadia Raab et al. Aug 01, 2025 pp. 110497 10.1016/j.jbc.2025.110497

An anti-CD47 antibody binds to a distinct epitope in a novel metal ion-dependent manner to minimize cross-linking of red blood cells

Xiao Lu, Ziyue Chen, Chunyan Yi et al. Aug 01, 2025 pp. 110420 10.1016/j.jbc.2025.110420

A key loop in the catalytic pocket of the PL17 family of alginate lyases determines minimal substrate recognition

Xue Li, Lanzeng Zhang, Yongqi Tang et al. Aug 01, 2025 pp. 110467 10.1016/j.jbc.2025.110467

Subcellular determinants of orthoflavivirus protease activity

Lochlain Corliss, Chad M. Petit, Nicholas J. Lennemann Aug 01, 2025 pp. 110451 10.1016/j.jbc.2025.110451

Functional investigation of the RNA helicase MOV10 with respect to its interplay with factors involved in nonsense-mediated mRNA decay

Guangpu Xue, Gabriel P. Faber, Lea S. Pommerening et al. Aug 01, 2025 pp. 110418 10.1016/j.jbc.2025.110418

Improvement in the potency of a N1-methylpseudouridine-modified self-amplifying RNA through mutations in the RNA-dependent RNA polymerase

Verónica Quintana, Josefina Caillava, Laura A. Byk et al. Aug 01, 2025 pp. 110487 10.1016/j.jbc.2025.110487

Ultrasensitive bioluminescent reporters of protein kinase A based on luciferase activity modulated by phosphorylation (PKA LAMP)

Yufang Kong, Stefan Strack Aug 01, 2025 pp. 110445 10.1016/j.jbc.2025.110445

Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains

Nicolas Rolfe, Kurt L. Schroeter, Taylor JB. Forrester et al. Aug 01, 2025 pp. 110439 10.1016/j.jbc.2025.110439

Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy

Xiao Yu, Jiang Cao, Binyu Wang et al. Aug 01, 2025 pp. 110398 10.1016/j.jbc.2025.110398

The impact of RNA chemical probing reagents on RNA-binding proteins

David Klingler, Lucy Fallon, Daniel Cohn et al. Aug 01, 2025 pp. 110468 10.1016/j.jbc.2025.110468

NMR-guided identification of CYP11A1–Adrenodoxin interactions that differentially govern cholesterol and vitamin D3 metabolism

Janie E. McGlohon, Jacob Logothetis, D. Fernando Estrada Aug 01, 2025 pp. 110428 10.1016/j.jbc.2025.110428

Molecular basis for Gβγ-SNARE-mediated inhibition of synaptic vesicle fusion

Anna R. Eitel, Benjamin K. Mueller, Ali I. Kaya et al. Aug 01, 2025 pp. 110377 10.1016/j.jbc.2025.110377

The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation

Kohjiro Nagao, Mayu Matsuo, Yoshie Hori et al. Aug 01, 2025 pp. 110457 10.1016/j.jbc.2025.110457

A molecular basis underpinning TRBV28+ T-cell receptor recognition of MR1–antigen

Wael Awad, Nicholas A. Gherardin, Lisa Ciacchi et al. Aug 01, 2025 pp. 110416 10.1016/j.jbc.2025.110416

Repurposing clofazimine as an antibiotic to treat cholera: Identification of cellular and structural targets

Ming Yuan, Martín Andrés González Montalvo, Yuyao Hu et al. Aug 01, 2025 pp. 110458 10.1016/j.jbc.2025.110458

Transcriptional responses to nitric oxide are widescale and source-dependent

Joseph C. Schindler, Puneet Seth, Richard T. Premont et al. Aug 01, 2025 pp. 110476 10.1016/j.jbc.2025.110476