Journal of Biological Chemistry

Conformations of the three gates in Saccharomyces cerevisiae topoisomerase II and their response to DNA, nucleotide, and etoposide

Jampa Tsedön Stelljes, Dagmar Klostermeier Aug 01, 2025 pp. 110495 10.1016/j.jbc.2025.110495

Cathepsin K as a key regulator of myocardial fibrosis in dilated cardiomyopathy and a promising therapeutic target

Lanlan Ma, Bingjun Lu, Yueqiao Si et al. Aug 01, 2025 pp. 110421 10.1016/j.jbc.2025.110421

TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail

Owen R. Moon, Andrew C. Newman, Abdullah S. Alanazi et al. Aug 01, 2025 pp. 110473 10.1016/j.jbc.2025.110473

Molecular determinants of nucleic acid recognition by an RNA-targeting ADP-ribosyltransferase toxin

Fanyang Lv, Andrea G. Alexei, Jake Colautti et al. Aug 01, 2025 pp. 110463 10.1016/j.jbc.2025.110463

Development of novel mitochondrial pyruvate carrier inhibitors for breast cancer treatment

Tanner J. Schumacher, Zachary S. Gardner, Jon Rumbley et al. Aug 01, 2025 pp. 110486 10.1016/j.jbc.2025.110486

The Escherichia coli RelB antitoxin C terminus is essential for RelE toxin suppression and transcriptional repression

Julia Tanquary, Ian J. Pavelich, Marcin Grabowicz et al. Aug 01, 2025 pp. 110389 10.1016/j.jbc.2025.110389

Engineered bacteriophytochrome heterodimers for research and applications

Iida Tuure, Cornelia Böhm, Jessica Rumfeldt et al. Aug 01, 2025 pp. 110452 10.1016/j.jbc.2025.110452

Cu/Zn-superoxide dismutase naturally fused with a β-propeller lactonase in Deinococcus radiodurans

Yoshiaki Furukawa, Masamichi Megata, Atsuko Shintani et al. Aug 01, 2025 pp. 110499 10.1016/j.jbc.2025.110499

Prediction of KIR3DL1 and human leukocyte antigen binding

Martin Maiers, Yoram Louzoun, Philip Pymm et al. Aug 01, 2025 pp. 110437 10.1016/j.jbc.2025.110437

A tubulin-binding protein that preferentially binds to GDP-tubulin and promotes GTP exchange

Wesley J. Yon, Taekjip Ha, Yixian Zheng et al. Aug 01, 2025 pp. 110401 10.1016/j.jbc.2025.110401

The critical roles of bioactive sphingolipids in inflammation

Ana Gomez-Larrauri, Asier Larrea-Sebal, César Martín et al. Aug 01, 2025 pp. 110475 10.1016/j.jbc.2025.110475

Vacuole protein sorting 18 (Vps18) suppresses epithelial growth factor receptor (EGFR) expression and lung tumorigenesis

Wuhou Dai, Shujing Zhang, Shunfei Yan et al. Aug 01, 2025 pp. 110447 10.1016/j.jbc.2025.110447

Zinc oxide nanoparticles disrupt peroxisome-endoplasmic reticulum contacts and increase very-long-chain fatty acid content

Juncheng Zhong, Xuebo Liu, Jiawei Wang et al. Aug 01, 2025 pp. 110488 10.1016/j.jbc.2025.110488

Molecular choreography of E1 enzymes in ubiquitin-like protein cascades: New insights into dynamics and specificity

Caleb M. Stratton, Pirouz Ebadi, Shaun K. Olsen Aug 01, 2025 pp. 110415 10.1016/j.jbc.2025.110415

The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65

Xinyu Liu, Yu Lin, Weibing Long et al. Aug 01, 2025 pp. 110461 10.1016/j.jbc.2025.110461

Arylsulfatase B induces melanoma apoptosis by the ubiquitin ligase COP1

Sumit Bhattacharyya, Insug O-Sullivan, Herbert E. Whiteley et al. Aug 01, 2025 pp. 110402 10.1016/j.jbc.2025.110402

Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak

Michel V. Levesque, Andreane Cartier, Yueh-Chien Lin et al. Aug 01, 2025 pp. 110455 10.1016/j.jbc.2025.110455

Targeted degradation of α-synuclein by arginine-based PROTACs

Linjing Shen, Jianchao Zhang, Zhaoran Wang et al. Aug 01, 2025 pp. 110449 10.1016/j.jbc.2025.110449

A kinetic model of copper homeostasis in Saccharomyces cerevisiae

Cade Dulaney, Jay R. Walton, Paul A. Lindahl Aug 01, 2025 pp. 110368 10.1016/j.jbc.2025.110368

PERK and IRE1α promote exosome secretion via blocking lysosomal degradation of multiple vesicular body

Shixin Zhou, Zihan Zhou, Si Chen et al. Aug 01, 2025 pp. 110504 10.1016/j.jbc.2025.110504

Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer

Tomohito Tanihara, Yuya Yoshida, Takashi Ogino et al. Aug 01, 2025 pp. 110414 10.1016/j.jbc.2025.110414

Failed cellular surveillance enables pathogenic matrix deposition in a COL2A1-related osteoarthritis

Kathryn M. Yammine, Sophia Mirda Abularach, Michael Xiong et al. Aug 01, 2025 pp. 110436 10.1016/j.jbc.2025.110436

GoLoco/GPR motif-dependent regulation of Rap1GAP1 by Gαo is disrupted by Gαo encephalopathy variants

Nathalie L. Momplaisir, Naincy R. Chandan, Beiyun Wang et al. Aug 01, 2025 pp. 110446 10.1016/j.jbc.2025.110446

Extensive citrullination of human serum albumin is physiological and not inherently immunogenic in rheumatoid arthritis

Cecilia Mustelin, Archana Einstein, Xiaoxing Wang et al. Aug 01, 2025 pp. 110438 10.1016/j.jbc.2025.110438

Insights into the structural dynamics of the secretin family (class B1) G protein-coupled receptors

Ting Liu, Narisa Ria Naidoo, Eugene Agyemang et al. Aug 01, 2025 pp. 110466 10.1016/j.jbc.2025.110466