Journal of Biological Chemistry

Sidt2 inhibits islet β-cell dedifferentiation by regulating insulin secretion

Jing Gu, Meng-Xiang Qi, Rui-Xi Zhang et al. Sep 01, 2025 pp. 110544 10.1016/j.jbc.2025.110544

The U1 snRNP-specific protein U1C is a key regulator of SMN complex–mediated snRNP formation

Duc Minh Ngu, Sanat Myti, Ayesha Ali Khan et al. Sep 01, 2025 pp. 110514 10.1016/j.jbc.2025.110514

ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus

Bao-Di Ma, Jia-Yi Li, Jian-He Xu et al. Sep 01, 2025 pp. 110599 10.1016/j.jbc.2025.110599

A dynamic structural framework for the allosteric regulation of Hsp70 chaperones

Lukas Rohland, Roman Kityk, Luka Smalinskaitė-Wolf et al. Sep 01, 2025 pp. 110516 10.1016/j.jbc.2025.110516

Molecular determinants of picornavirus 3C protease binding to phosphoinositide-enriched lipid membranes

Jie Yu, Dennis S. Winston, David D. Boehr Sep 01, 2025 pp. 110543 10.1016/j.jbc.2025.110543

Distinct domains of LINGO1 control surface expression and biophysical properties of large conductance Ca2+- and voltage-activated potassium (BK) channels

Yaly Al Kawadri, Heather McClafferty, Srikanth Dudem et al. Sep 01, 2025 pp. 110550 10.1016/j.jbc.2025.110550

Structural insights into the substrate transport mechanism of the amino acid transporter complex

Haonan Yang, Tianhao Shi, Jing Dong et al. Sep 01, 2025 pp. 110569 10.1016/j.jbc.2025.110569

Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells

Md Mohsin Ali, Intawat Nookaew, Ana Resende-Coelho et al. Sep 01, 2025 pp. 110551 10.1016/j.jbc.2025.110551

SMAD1/5-mediated recruitment of the histone demethylase KDM1A controls cell fate programs in embryonic stem cells

Masato Morikawa, Daizo Koinuma, Hiroaki Sakai et al. Sep 01, 2025 pp. 110591 10.1016/j.jbc.2025.110591

Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival

Alexander M. Warwick, Lin Yu, Mikael Klingeborn et al. Sep 01, 2025 pp. 110586 10.1016/j.jbc.2025.110586

ATP hydrolysis-driven structural transitions within the Saccharomyces cerevisiae Rad51 and Dmc1 nucleoprotein filaments

Yeonoh Shin, Stefan Y. Kim, Eric C. Greene Sep 01, 2025 pp. 110528 10.1016/j.jbc.2025.110528

Molecular recognition of fungal methylated glucosylceramides by ETD151 defensin

Ons Kharrat, Françoise Paquet, Rouba Nasreddine et al. Sep 01, 2025 pp. 110587 10.1016/j.jbc.2025.110587

Opt1 imports CoA precursors as glutathione mixed disulfides

Jouke Jan Wedman, Lotte de Vries, Bart van Lingen et al. Sep 01, 2025 pp. 110503 10.1016/j.jbc.2025.110503

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation

Runtai Chen, Seyed Amirhossein Tabatabaei Dakhili, Rokas Gerulskis et al. Sep 01, 2025 pp. 110555 10.1016/j.jbc.2025.110555

Regulator of G protein signaling 2 as a suppressor of sphingosine-1-phosphate 2– and 3–mediated signaling in colon cancer cells

Jaejun Eo, Nahyun Kim, Sungho Ghil Sep 01, 2025 pp. 110554 10.1016/j.jbc.2025.110554

Potent antioxidant and mitochondrial-protective effects of ATH434, a moderate affinity iron chaperone

Danielle K. Bailey, Rhudwan Nihlawi, Margaret J. Bradbury et al. Sep 01, 2025 pp. 110595 10.1016/j.jbc.2025.110595

Modeling Mycobacterium tuberculosis pathogenesis in lung epithelial organoids reveals strain-specific host responses and intercellular crosstalk

Ruiqi Zhang, Fusheng Yao, Yanhong Huang et al. Sep 01, 2025 pp. 110534 10.1016/j.jbc.2025.110534

Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor

Ali A. Al-Hashimi, Paul Lebeau, Fadwa Majeed et al. Sep 01, 2025 pp. 110506 10.1016/j.jbc.2025.110506

Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

Takuya Otsuki, Shigeyuki Matsumoto, Junso Fujita et al. Sep 01, 2025 pp. 110548 10.1016/j.jbc.2025.110548

Activation of the stress-activated protein kinase JNK in response to herpes simplex virus-1 infection coordinates transition of BRD4 from chromosome association to transcription elongation

Weikang Sun, Ke Ren, Jingjing Li et al. Sep 01, 2025 pp. 110590 10.1016/j.jbc.2025.110590

Multifunctional molecular agent for tau-targeted combinational therapy of Alzheimer’s disease

Junjie Wu, Keke Chai, Ying Tu et al. Sep 01, 2025 pp. 110583 10.1016/j.jbc.2025.110583

N4BP1 is a nucleocytoplasmic shuttling protein and recognizes aggregates of the ubiquitin-like protein NEDD8 to protect cells under heat shock

Xiaohong Guo, Yuhan Ke, Yuanmeng Chen et al. Sep 01, 2025 pp. 110511 10.1016/j.jbc.2025.110511

The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells

Layla El-Sawy, John R. Rubin, Luke Broses et al. Sep 01, 2025 pp. 110531 10.1016/j.jbc.2025.110531

A non-coding RNA circGNAI2 suppresses triple-negative breast cancer progression by sponging miR-454-3p to inhibit the VGLL4-STAT3 signaling

Hongming Song, Jing Peng, Zhaohe Niu et al. Sep 01, 2025 pp. 110577 10.1016/j.jbc.2025.110577

Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

Philipp. Ross, Hugo G. Hilton, Jane Lodwick et al. Sep 01, 2025 pp. 110542 10.1016/j.jbc.2025.110542